Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-RelB
Location 4685673..4686280 Replicon chromosome
Accession NZ_CP051652
Organism Pectobacterium carotovorum strain WPP14

Toxin (Protein)


Gene name doc Uniprot ID A0A7V8T7U1
Locus tag HER17_RS20930 Protein ID WP_010300678.1
Coordinates 4685891..4686280 (+) Length 130 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID C6DIE5
Locus tag HER17_RS20925 Protein ID WP_010300679.1
Coordinates 4685673..4685894 (+) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HER17_RS20900 4681029..4681937 + 909 WP_014913736.1 LysR family transcriptional regulator -
HER17_RS20905 4682036..4682899 + 864 WP_010300687.1 YicC family protein -
HER17_RS20910 4683252..4683614 - 363 WP_072037086.1 hypothetical protein -
HER17_RS20915 4683959..4684267 + 309 WP_010300685.1 hypothetical protein -
HER17_RS20920 4684510..4685334 + 825 WP_010300683.1 DNA damage-inducible protein D -
HER17_RS20925 4685673..4685894 + 222 WP_010300679.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
HER17_RS20930 4685891..4686280 + 390 WP_010300678.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
HER17_RS20935 4686623..4687417 + 795 WP_010300676.1 class I SAM-dependent methyltransferase -
HER17_RS20940 4687696..4688253 + 558 WP_010300674.1 hypothetical protein -
HER17_RS20945 4688301..4688846 - 546 WP_010300672.1 hypothetical protein -
HER17_RS20950 4688960..4689346 + 387 WP_010300669.1 hypothetical protein -
HER17_RS20955 4689389..4689752 + 364 Protein_4089 DUF596 domain-containing protein -
HER17_RS20960 4689763..4690977 - 1215 WP_010300665.1 AI-2E family transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Death on curing protein

(5-120)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-53)


Sequences

Toxin        


Download         Length: 130 a.a.        Molecular weight: 14583.43 Da        Isoelectric Point: 5.9739

>T154614 WP_010300678.1 NZ_CP051652:4685891-4686280 [Pectobacterium carotovorum]
MNWVSAQEVIAFHDRILQRLPGVAGMPDPGRAEAIIYRVQNRTHYEGITDVFELAATYWVAVARGHIFNDGNKRTAFFVT
MTFLYRNGVLVRDHDNTLENLTVEAATGAKNVDQLAQHLRNLEDEISPT

Download         Length: 390 bp

>T154614 NZ_CP068158:1597416-1597607 [Corynebacterium striatum]
ATGTGGAAGCTGCGCCAGCTTGGGTACGCGCAGACTCTTGATGAGTTACGGATTCCCCCGGGAAACCGGCTTGAGGCGCT
CAAAGGCGATCGCAGGGGTCAACATAGTATTCGCATCAACGACCAGTGGCGGATCTGTTTTCGGTGGTCCGCCGCGGGGA
CAGAGGAGGTTGAGATCGTTGACTACCACTGA

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8135.01 Da        Isoelectric Point: 5.0359

>AT154614 WP_010300679.1 NZ_CP051652:4685673-4685894 [Pectobacterium carotovorum]
MRTYTSTQARANISEVLDAATHGEPVEITRRDGSSAVVISKAEFEAYQNAKLDAEFDLIMQRHGHTIEALTDR

Download         Length: 222 bp

>AT154614 NZ_CP068158:1597594-1597902 [Corynebacterium striatum]
TTGACTACCACTGACAAGCTCCCTCCGGTTCACCCCGGTGAGATCCTCATGGAGGACTTTCTCAAAGGAATGGGGCTCAC
CCAGCACAAGCTCGCCGTCTCCATCGGCGTTCTGCCCCGCCGGATCAACGAAATTGTTCACGGTAAGCGCGCTGTAACCG
CTGACACGGCCCTTCGTCCAGCGAAGTTTTTCGAGATGAGCCCCCAGTTCTGGCTCGGGTTACAGGCTCAATATGACTTG
GACGTGGCGGAAGACAAGATCCTCTCGGAAATCAAGCGGATTCAACCGGTCCAAGCTGTCTCAGCGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7V8T7U1

Antitoxin

Source ID Structure
AlphaFold DB A0A221TFG2

References