154613

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relB-parE/ParE-RHH
Location 4321246..4321829 Replicon chromosome
Accession NZ_CP051652
Organism Pectobacterium carotovorum strain WPP14

Toxin (Protein)


Gene name parE Uniprot ID A0A7V8PTK4
Locus tag HER17_RS19230 Protein ID WP_010296214.1
Coordinates 4321246..4321551 (-) Length 102 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A7V8PT23
Locus tag HER17_RS19235 Protein ID WP_010296210.1
Coordinates 4321539..4321829 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HER17_RS19215 4317605..4318564 + 960 WP_029367586.1 ABC transporter permease -
HER17_RS19220 4318557..4319423 + 867 WP_010296221.1 ABC transporter permease -
HER17_RS19225 4319420..4321126 + 1707 WP_010296218.1 ABC transporter ATP-binding protein -
HER17_RS19230 4321246..4321551 - 306 WP_010296214.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HER17_RS19235 4321539..4321829 - 291 WP_010296210.1 ribbon-helix-helix protein, CopG family Antitoxin
HER17_RS19240 4321891..4322745 - 855 WP_029367584.1 helix-turn-helix domain-containing protein -
HER17_RS19245 4322770..4323609 - 840 WP_010296204.1 HTH-type transcriptional activator RhaS -
HER17_RS19250 4323946..4325436 + 1491 WP_010296202.1 rhamnulokinase -
HER17_RS19255 4325433..4326695 + 1263 WP_010296200.1 L-rhamnose isomerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-96)

Antitoxin

Ribbon-helix-helix protein, CopG

(9-46)


Sequences

Toxin        


Download         Length: 102 a.a.        Molecular weight: 11576.44 Da        Isoelectric Point: 9.8325

>T154613 WP_010296214.1 NZ_CP051652:c4321551-4321246 [Pectobacterium carotovorum]
MPQVIVSERARRDLQRLQDFLKNKNALAAKKAAEVLIRGIRQLEALPNIGRPVEHLPLEYQELVIEFGSSGYVMLYRHDE
LTGRVVILTVKHQKEAGYQNP

Download         Length: 306 bp

>T154613 NZ_CP068155:c4774200-4774024 [Escherichia coli]
GTGAAACAAAGCGAGTTCAGACGTTGGCTCGAATCTCAGGGCGTCGATGTAGCGAATGGCAGCAACCATTTGAAACTCAG
GTTTCATGGGAGGCGCAGTGTCATGCCGCGTCACCCCTGCGATGAGATTAAAGAACCATTGCGTAAAGCAATCCTGAAAC
AACTCGGTTTGAGTTAA

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 11064.13 Da        Isoelectric Point: 4.7692

>AT154613 WP_010296210.1 NZ_CP051652:c4321829-4321539 [Pectobacterium carotovorum]
MADTTRQTTTLRIDQDIKERLKTLADDRNSSAHALMLEAIAEYVEREEKRSQYRKEALAAWEDYQDTGKHITADETVTWL
ESWGSGHEQDAPACHK

Download         Length: 291 bp

>AT154613 NZ_CP068155:c4773978-4773562 [Escherichia coli]
ATGCGTTATCCCGTCACTCTTACACCCGCGCCGGAAGGCGGTTATATGGTTTCTTTTGTGGATATCCCTGAAGCGTTGAC
GCAGGGCGAAACTGTCGCTGAAGCGATGGAAGCGGCAAAAGATGCTTTACTGACCGCATTTGATTTTTATTTTGAAGATA
ACGAGCTTATCCCTTTACCTTCGCCATTAAATAGTCATGATCACTTTATTGAAGTACCTTTGAGCGTCGCCTCTAAGGTA
TTGCTGTTAAATGCTTTTTTACAGTCAGAAATCACTCAGCAAGAGTTAGCCAGGCGAATTGGCAAACCTAAACAGGAGAT
TACTCGCCTATTTAACTTGCATCATGCGACAAAAATCGACGCCGTCCAGCTCGCGGCAAAGGCGCTTGGCAAAGAGTTAT
CGCTGGTGATGGTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7V8PTK4

Antitoxin

Source ID Structure
AlphaFold DB A0A7V8PT23

References