Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3541856..3542481 Replicon chromosome
Accession NZ_CP051652
Organism Pectobacterium carotovorum strain WPP14

Toxin (Protein)


Gene name Hha Uniprot ID C6DB72
Locus tag HER17_RS15760 Protein ID WP_005976087.1
Coordinates 3542278..3542481 (+) Length 68 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID C6DB73
Locus tag HER17_RS15755 Protein ID WP_005976089.1
Coordinates 3541856..3542224 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HER17_RS15740 3537500..3540628 + 3129 WP_010303023.1 multidrug efflux RND transporter permease subunit -
HER17_RS15745 3540847..3541095 + 249 WP_010303021.1 type B 50S ribosomal protein L31 -
HER17_RS15750 3541113..3541256 + 144 WP_005976091.1 type B 50S ribosomal protein L36 -
HER17_RS15755 3541856..3542224 + 369 WP_005976089.1 Hha toxicity modulator TomB Antitoxin
HER17_RS15760 3542278..3542481 + 204 WP_005976087.1 hemolysin expression modulator Hha Toxin
HER17_RS15770 3543225..3543545 + 321 WP_010282239.1 MGMT family protein -
HER17_RS15775 3543565..3544146 - 582 WP_010303016.1 YbaY family lipoprotein -
HER17_RS15780 3544359..3545222 + 864 WP_010303014.1 acyl-CoA thioesterase II -
HER17_RS15785 3545359..3546645 - 1287 WP_039472387.1 ammonium transporter AmtB -
HER17_RS15790 3546685..3547023 - 339 WP_002208627.1 P-II family nitrogen regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(8-64)

Antitoxin

Biofilm formation regulator YbaJ

(1-118)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 8145.52 Da        Isoelectric Point: 8.9008

>T154609 WP_005976087.1 NZ_CP051652:3542278-3542481 [Pectobacterium carotovorum]
MKKIDYLMRLRKCTTIDTLERVIEKNKYELSNDELEMFFSAADHRLAELTMNKLYDKVPTAVWRYVR

Download         Length: 204 bp

>T154609 NZ_CP068155:c3081679-3081272 [Escherichia coli]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATCCACGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCGCTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGACGCATTAATGCTCGCCAGGGAGAAATTCGCCTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCGCCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGATAGCGGTAAACGGCA
ACATTTATGGCTGGCAGCCGACAGCATGGACGAAGCCGAATGGCGGGATTTACGGCGGATATTGTTGCAACAAGAGACGC
AAAGATAA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 14032.77 Da        Isoelectric Point: 4.4787

>AT154609 WP_005976089.1 NZ_CP051652:3541856-3542224 [Pectobacterium carotovorum]
MDEYTPKHYDIAQLRFLCENLCDESIATLGDSSHGWVNDPTSAINLQLNELIEHIATFILTFKIKYPNESELSEQVEKYL
DDTYVLFSNYGINDAELRRWQKSKAKLFGMFSGENVCTPAKT

Download         Length: 369 bp

>AT154609 NZ_CP068155:c3081926-3081660 [Escherichia coli]
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAATGTGACGATCCCGATC
TGTTCAACTGGCTGATGAATCATGGTAAACCGGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1D7Z3F0

Antitoxin

Source ID Structure
AlphaFold DB A0A1D7Z3G5

References