Detailed information of TA system TA154608

Bioinformatically predicted

Overview

TA module

• Type: VII
• Classification (family/domain): HepT-MntA/HepT(toxin)
• Location: 3290506..3291305
• Replicon: chromosome
• Accession: NZ_CP051652
• Organism: Pectobacterium carotovorum strain WPP14

Toxin (Protein)

• Gene name: hepT
• Uniprot ID: A0A7V8TG63
• Locus tag: HER17_RS14630
• Protein ID: WP_010296752.1
• Coordinates: 3290886..3291305 (+)
• Length: 140 a.a.

Antitoxin (Protein)

• Gene name: mntA
• Uniprot ID: -
• Locus tag: HER17_RS14625
• Protein ID: WP_010296754.1
• Coordinates: 3290506..3290889 (+)
• Length: 128 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HER17_RS14610	3285716..3286852	-	1137	WP_010296760.1	polysaccharide export protein	-
HER17_RS14615	3286978..3288057	-	1080	WP_039506648.1	UDP-N-acetylglucosamine--undecaprenyl-phosphate N-acetylglucosaminephosphotransferase	-
HER17_RS14620	3288807..3290393	+	1587	WP_010296756.1	TerC family protein	-
HER17_RS14625	3290506..3290889	+	384	WP_010296754.1	nucleotidyltransferase domain-containing protein	Antitoxin
HER17_RS14630	3290886..3291305	+	420	WP_010296752.1	DUF86 domain-containing protein	Toxin
HER17_RS14635	3291349..3292701	-	1353	WP_010296751.1	anaerobic C4-dicarboxylate transporter DcuC	-
HER17_RS14640	3292965..3294800	-	1836	WP_010296749.1	outer membrane assembly protein AsmA	-
HER17_RS14645	3294864..3295445	-	582	WP_005974037.1	dCTP deaminase	-
HER17_RS14650	3295553..3296194	-	642	WP_010296746.1	uridine kinase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Ribonuclease HepT-like (13-130)

Antitoxin

• Polymerase beta, nucleotidyltransferase (4-93)

Sequences

Toxin

Protein

• Length: 140 a.a.
• Molecular weight: 16052.37 Da
• Isoelectric Point: 6.9682

>T154608 WP_010296752.1 NZ_CP051652:3290886-3291305 [Pectobacterium carotovorum]
MTDILLNKSSTIQRCLRRIREEFDTEEGFRQNFTKQDSVILNIQRACEAAIDIANYLIRIKQLGIPQSSRDSFALLAANQ
IITIDLSDNLQKMVGLRNIAVHDYQALNLDIVIHVISHRLSDFEHFIKQIARYSDSQHL

Nucleotide

• Length: 420 bp

>T154608 NZ_CP068155:c3067288-3066911 [Escherichia coli]
ATGAAAACATTACCCAACACACACGTACGGGAGGCATCGCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTGTC
CCGGTTGCTGGACCAGCATTACGGCCTTACGCTGAATGACACACCGTTCGCCGATGAACGTGTGATTGAGCAGCATATTG
AAGCTGGCATTTCACTGTGTGATGCGGTGAGCTTTCTCGTTGAAAAATACGCACTGGTACGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGCTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCACGCCGGGCAACCGGCCTGATGACACGCGA
CAACTACAGAACGGTAAATAACATTACCCTGGGTAAACATCCGGGGGCGAAACAATGA

Antitoxin

Protein

• Length: 128 a.a.
• Molecular weight: 14388.57 Da
• Isoelectric Point: 4.7463

>AT154608 WP_010296754.1 NZ_CP051652:3290506-3290889 [Pectobacterium carotovorum]
MFDKIVLTLKKQMPDIKIIYLFGSQATGNARADSDIDIAIMATRALDPVERWELSNQLAKEVGHDVDLIDLLQASTVLKM
EIVRNGKLLYDSETAAGEFEMTTLSMYQHLQKERADIIRSFNQDLKA

Nucleotide

• Length: 384 bp

>AT154608 NZ_CP068155:c3067746-3067378 [Escherichia coli]
GTGTCAGACACACTGCCCGGGACAACGCATCCCGACAACAACAACGACCGCCCCTGGTGGGGGCTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTACAGACCGCGCCGGTATCAGAGGCCGGT
TCAGCGACGCGGATTCGTACCACCTGAACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTGACACTGTATGCGAAAGGGCTGACCTGCGAAGCCGACACCTTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACGCCCGAAACGAAAAAGTAA

Structures

Toxin

• AlphaFold DB: A0A7V8TG63