Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 1083080..1083605 Replicon chromosome
Accession NZ_CP051652
Organism Pectobacterium carotovorum strain WPP14

Toxin (Protein)


Gene name relE Uniprot ID A0A1D7Z1B4
Locus tag HER17_RS04805 Protein ID WP_005973612.1
Coordinates 1083321..1083605 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID C6D956
Locus tag HER17_RS04800 Protein ID WP_005973616.1
Coordinates 1083080..1083331 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HER17_RS04775 1078556..1078846 + 291 WP_010308412.1 hypothetical protein -
HER17_RS04780 1079138..1079485 - 348 WP_004114521.1 hypothetical protein -
HER17_RS04785 1079509..1079736 - 228 WP_004114519.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
HER17_RS04790 1080367..1080900 - 534 WP_139294543.1 hypothetical protein -
HER17_RS04795 1081165..1082607 + 1443 WP_049776292.1 IS1182 family transposase -
HER17_RS04800 1083080..1083331 + 252 WP_005973616.1 prevent-host-death protein Antitoxin
HER17_RS04805 1083321..1083605 + 285 WP_005973612.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HER17_RS04810 1084024..1084214 + 191 Protein_937 recombinase -
HER17_RS04815 1085547..1086194 - 648 WP_010308382.1 EcsC family protein -
HER17_RS04820 1086617..1087102 + 486 WP_180890113.1 Hcp family type VI secretion system effector -
HER17_RS04825 1087546..1088178 - 633 WP_010303180.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1067702..1089415 21713
- flank IS/Tn - - 1081165..1082607 1442


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11010.96 Da        Isoelectric Point: 10.1716

>T154606 WP_005973612.1 NZ_CP051652:1083321-1083605 [Pectobacterium carotovorum]
MSYKLEFEEHALKEFKKLGAPVREQFTKKLKEVLQNPHVPANRLHGMADCYKIKLRSAGYRLVYQVLEHEIVVLVLAVGK
RERSEVYKTAKDRL

Download         Length: 285 bp

>T154606 NZ_CP068155:2909826-2910140 [Escherichia coli]
ATGCACCTGATAACTCAAAAAGCATTGAAAGATGCTGCGGAAAAATACCCGCAACATAAAACGGAGTTGGTGGCTCTGGG
GAACACGATTGCTAAGGGATATTTCAAAAAACCTGAGTCATTAAAAGCAGTATTCCCATCTCTGGATAACTTCAAATATC
TGGATAAGCATTATGTTTTCAATGTTGGGGGCAATGAATTACGTGTTGTAGCAATGGTCTTTTTTGAATCGCAAAAGTGC
TACATACGTGAAGTTATGACGCATAAAGAATACGATTTCTTTACCGCTGTTCATCGTACTAAGGGGAAAAAATGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9079.35 Da        Isoelectric Point: 5.0807

>AT154606 WP_005973616.1 NZ_CP051652:1083080-1083331 [Pectobacterium carotovorum]
MSVQPILANAAVSISDFKKSPNAALKEANGEPVAVLTNGRISGYYVSPETWEALADYQEDIELAKIARSRMKGKRVKVDL
DEL

Download         Length: 252 bp

>AT154606 NZ_CP068155:2910137-2910553 [Escherichia coli]
ATGATTGCGATTGCCGACATCTTGCAAGCAGGAGAAAAGCTAACTGCTGTGGCACCTTTTCTGGCGGGTATTCAGAACGA
GGAACAATACACCCAGGCGCTGGAACTGGTAGATCATCTGCTGCTCAACGATCCTGAAAACCCCTTGCTGGATCTGGTGT
GTGCCAAAATAACCGCGTGGGAAGAATCAGCGCCCGAATTTGCGGAATTTAATGCCATGGCTCAAGCCATGCCTGGCGGT
ATAGCCGTGATTCGTACCCTTATGGATCAATATGGTTTAACCCTTTCCGATCTGCCGGAAATTGGCAGTAAATCTATGGT
GTCACGCGTTTTGAGCGGGAAGAGGAAATTAACGCTGGAACACGCTAAAAAATTGGCAACGCGATTCGGCATTTCTCCCG
CCTTGTTTATTGATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1D7Z1B4

Antitoxin

Source ID Structure
AlphaFold DB A0A0G4JQP6

References