Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 828567..829207 Replicon chromosome
Accession NZ_CP051652
Organism Pectobacterium carotovorum strain WPP14

Toxin (Protein)


Gene name vagD Uniprot ID -
Locus tag HER17_RS03645 Protein ID WP_010295080.1
Coordinates 828791..829207 (+) Length 139 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID -
Locus tag HER17_RS03640 Protein ID WP_010295083.1
Coordinates 828567..828794 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HER17_RS03615 823602..824081 - 480 WP_010295094.1 Hcp family type VI secretion system effector -
HER17_RS03620 824200..824703 - 504 WP_010295092.1 M48 family metallopeptidase -
HER17_RS03625 824872..826065 - 1194 WP_010295091.1 aspartate/tyrosine/aromatic aminotransferase -
HER17_RS03630 826130..826744 - 615 WP_010295088.1 YitT family protein -
HER17_RS03635 826993..827472 - 480 WP_010295086.1 Lrp/AsnC family transcriptional regulator -
HER17_RS03640 828567..828794 + 228 WP_010295083.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
HER17_RS03645 828791..829207 + 417 WP_010295080.1 type II toxin-antitoxin system VapC family toxin Toxin
HER17_RS03650 829346..829984 - 639 WP_010295078.1 hypothetical protein -
HER17_RS03655 829977..831059 - 1083 WP_010295075.1 alanine racemase -
HER17_RS03660 831101..832507 - 1407 WP_010295074.1 replicative DNA helicase -
HER17_RS03665 832755..833741 + 987 WP_010295071.1 quinone oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(6-129)

Antitoxin

SpoVT-AbrB domain

(7-55)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 15216.77 Da        Isoelectric Point: 8.7720

>T154605 WP_010295080.1 NZ_CP051652:828791-829207 [Pectobacterium carotovorum]
VSRLFMLDTNICSFIMREHPAEVIEKLQQCTLRRDRIVVSAITYAEMRFGAVGKKASPRHMQLVDAFCRRLDAVLPWDSA
AVDATTKIKIALAAAGTPIGPNDTAIAGHAISAKAILVTNNLREFERVPGLTLEDWVK

Download         Length: 417 bp

>T154605 NZ_CP068155:c2867057-2866593 [Escherichia coli]
ATGGATTTTCCACAAAGGGTTAATGGTTGGGCGCTATATGCTCATCCCTGTTTTCAGGAAACCTACGACGCTTTAGTTGC
CGAAGTCGAGACATTAAAGGGAAAAGATCCTGAAAATTATCAGAGAAAAGCCGCCACAAAGTTATTGGCGGTAGTCCATA
AAGTGATTGAGGAGCATATCACGGTCAATCCATCATCACCGGCATTCCGTCATGGCAAGTCGTTAGGCTCTGGGAAAAAT
AAAGACTGGTCACGGGTAAAATTTGGTGCTGGTCGTTATCGTCTCTTCTTTCGTTATAGTGAAAAAGAGAAAGTCATCAT
TCTGGGATGGATGAACGATGAAAACACTCTGCGCACCTACGGTAAAAAAACAGATGCCTATACCGTATTCAGCAAAATGT
TAAAAAGAGGACATCCTCCTGCCGACTGGGAAACCCTCACCCGAGAAACAGAAGAAACCCATTGA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8908.08 Da        Isoelectric Point: 4.5216

>AT154605 WP_010295083.1 NZ_CP051652:828567-828794 [Pectobacterium carotovorum]
MRIVSVFKNGNNRAIRLPRDMDFEGVNELEIVREGDTIMLRPIKPNWHSFLQEERADADFMTERQDVVEEGRFEL

Download         Length: 228 bp

>AT154605 NZ_CP068155:c2867392-2867057 [Escherichia coli]
ATGCCCGCTAATGCTCGCTCTCACGCTGTACTGACCACTGAATCAAAGGTCACGATACGCGGACAAACAACTATCCCCGC
GCCAGTGCGTGAGGCCTTAAAACTGAAGCCAGGCCAGGACAGCATTCATTACGAAATTCTGCCTGGTGGGCAAGTATTTA
TGTGCCGACTGGGAGATGAACAGGAGGATCATACTATGAATGCATTTTTGCGTTTTCTGGATGCAGATATCCAGAACAAC
CCGCAAAAAACTCGTCCATTCAACATTCAACAAGGAAAGAAACTTGTCGCTGGCATGGACGTCAACATTGATGATGAGAT
TGGCGACGACGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References