Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 1572474..1573142 Replicon chromosome
Accession NZ_CP051650
Organism Streptococcus pneumoniae strain B1900

Toxin (Protein)


Gene name hicA Uniprot ID A0A4J1QTX8
Locus tag HG605_RS07965 Protein ID WP_050262954.1
Coordinates 1572963..1573142 (-) Length 60 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID G0IC64
Locus tag HG605_RS07960 Protein ID WP_000961810.1
Coordinates 1572474..1572926 (-) Length 151 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HG605_RS07935 (HG605_08040) 1568364..1569107 - 744 WP_050154902.1 16S rRNA (uracil(1498)-N(3))-methyltransferase -
HG605_RS07940 (HG605_08045) 1569109..1570062 - 954 WP_050154904.1 50S ribosomal protein L11 methyltransferase -
HG605_RS07945 (HG605_08050) 1570197..1570625 - 429 WP_223616914.1 NUDIX hydrolase -
HG605_RS07950 (HG605_08055) 1570606..1571694 - 1089 WP_061646332.1 site-2 protease family protein -
HG605_RS07955 (HG605_08060) 1571713..1572183 - 471 WP_000257090.1 DUF3013 family protein -
HG605_RS07960 (HG605_08065) 1572474..1572926 - 453 WP_000961810.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
HG605_RS07965 (HG605_08070) 1572963..1573142 - 180 WP_050262954.1 type II toxin-antitoxin system HicA family toxin Toxin
HG605_RS07970 (HG605_08075) 1573279..1573527 - 249 WP_171964977.1 hypothetical protein -
HG605_RS07975 (HG605_08080) 1573517..1573756 - 240 WP_223616915.1 hypothetical protein -
HG605_RS07980 (HG605_08085) 1574016..1575287 + 1272 WP_223616916.1 replication-associated recombination protein A -
HG605_RS07990 (HG605_08095) 1575832..1577151 - 1320 WP_054384681.1 glycoside hydrolase family 32 protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(6-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(17-114)


Sequences

Toxin        


Download         Length: 60 a.a.        Molecular weight: 6679.87 Da        Isoelectric Point: 11.0174

>T154599 WP_050262954.1 NZ_CP051650:c1573142-1572963 [Streptococcus pneumoniae]
MPMTQKEMVKLLTAHGWIKTRGGKGSHIKIEKQGERPITIPHGELNKYTERGIRKQAGL

Download         Length: 180 bp

>T154599 NZ_CP068155:c1121714-1121316 [Escherichia coli]
ATGCGGGTATTCAAAACAAAACTTATTCGCCTGCAACTTACAGCAGAGGAACTTGATGCGTTAACGGCGGATTTTATTTC
CTATAAGCGTGACGGTGTTTTGCCAGATATATTTGGTCGCGATGCACTCTACGACGACTCGTTTACCTGGCCATTAATCA
AATTTGAGCGAGTTGCTCATATTCATCTGGCAAATGTGAATAATCCATTTCCGCCACAGTTGCGCCAATTCAGCAGAACG
AATGACGAAGCGCATTTGGTATATTGTCAGGGTGCGTTTGATGAGCAAGCATGGTTGCTCATTGCCATTCTGAAACCTGA
ACCTCATAAACAGGCTCGAGATAACAACCAAATGCATAAAATTGGGAAAATGGCAGAAGCGTTTCGCATGCGTTTTTGA

Antitoxin


Download         Length: 151 a.a.        Molecular weight: 16659.46 Da        Isoelectric Point: 3.7220

>AT154599 WP_000961810.1 NZ_CP051650:c1572926-1572474 [Streptococcus pneumoniae]
MLVTYPALFYYDDTDGTEATYFVHFPDFEYSATQGEGISEALAMGSEWLGITVADLIESDGELPQPSDINSLSLIDNDPF
KDDEDFVSTYDLDKSFISMVSVDVSEYLGSQEPIKKTLTIPKWADKLGREMGLNFSQTLTDAIADKKVQA

Download         Length: 453 bp

>AT154599 NZ_CP068155:c1122010-1121717 [Escherichia coli]
ATGCATCGAATTCTCGCTGAAAAATCGGTCAATATTACTGAGTTACGTAAAAACCCAGCTAAATACTTTATTGATCAACC
GGTTGCGGTTCTTTCTAATAATCGCCCCGCAGGATATCTCTTAAGTGCCAGCGCATTCGAAGCGTTAATGGACATGCTTG
CTGAACAAGAGGAGAAAAAGCCCATAAAGGCGCGCTTCCGTCCAAGTGCTGCAAGATTAGAGGAAATTACACGCCGAGCT
GAAAAATATCTTAATGATATGACGGATGATGATTTCAATGACTTTAAGGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4J1QTX8

Antitoxin

Source ID Structure
PDB 5YRZ
AlphaFold DB G0IC64

References