Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 1092504..1093002 Replicon chromosome
Accession NZ_CP051650
Organism Streptococcus pneumoniae strain B1900

Toxin (Protein)


Gene name relE Uniprot ID B1IC19
Locus tag HG605_RS05490 Protein ID WP_001809704.1
Coordinates 1092504..1092758 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID B1IC20
Locus tag HG605_RS05495 Protein ID WP_000208080.1
Coordinates 1092760..1093002 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HG605_RS05475 (HG605_05505) 1087777..1090245 - 2469 WP_001152994.1 DNA gyrase subunit A -
HG605_RS05480 (HG605_05510) 1090439..1091425 + 987 WP_223616749.1 L-lactate dehydrogenase -
HG605_RS05485 (HG605_05515) 1091714..1092457 - 744 WP_050155013.1 ion channel -
HG605_RS05490 (HG605_05520) 1092504..1092758 - 255 WP_001809704.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HG605_RS05495 (HG605_05525) 1092760..1093002 - 243 WP_000208080.1 DUF6290 family protein Antitoxin
HG605_RS05500 (HG605_05530) 1093093..1093902 - 810 WP_001289493.1 MBL fold metallo-hydrolase -
HG605_RS05505 (HG605_05535) 1093904..1095253 - 1350 WP_000886210.1 cell wall metabolism sensor histidine kinase VicK -
HG605_RS05510 (HG605_05540) 1095246..1095950 - 705 WP_000722076.1 response regulator YycF -
HG605_RS05515 (HG605_05545) 1096006..1097181 - 1176 WP_000886145.1 A/G-specific adenine glycosylase -
HG605_RS10485 1097278..1097403 + 126 WP_001818232.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(7-84)

Antitoxin

Protein of unknown function DUF6290

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10098.79 Da        Isoelectric Point: 10.7632

>T154597 WP_001809704.1 NZ_CP051650:c1092758-1092504 [Streptococcus pneumoniae]
MYKLVPTRRFIKQLKKLDRYTQKLITNYLQTNVLEDPRRHGKALVGNRVGQWRYRIGNYRVIVQIVDDELVVATLEVGHR
RDIY

Download         Length: 255 bp

>T154597 NZ_CP068155:57420-57527 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGACTTTCTGGCACGACCTGGCGGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9205.46 Da        Isoelectric Point: 4.0527

>AT154597 WP_000208080.1 NZ_CP051650:c1093002-1092760 [Streptococcus pneumoniae]
MTTITLKVSEADKTFMKAMAKFEGVSLSELIRTKTLEALEDEYDARVADLAYQEYLEDLEKGVEPITWEEMMHDLGLKDE

Download         Length: 243 bp

>AT154597 NZ_CP068155:c57373-57307 [Escherichia coli]
TGTCTGGTTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A853PEW4

Antitoxin

Source ID Structure
AlphaFold DB A0A064C2J7

References