Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pemIK/MazF-doc
Location 20704..21287 Replicon plasmid pSY333-41
Accession NZ_CP051645
Organism Staphylococcus caprae strain SY333

Toxin (Protein)


Gene name pemK Uniprot ID A0A1S1GRQ5
Locus tag HHJ99_RS13275 Protein ID WP_002436882.1
Coordinates 20949..21287 (+) Length 113 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID -
Locus tag HHJ99_RS13270 Protein ID WP_176746841.1
Coordinates 20704..20952 (+) Length 83 a.a.

Genomic Context

HHJ99_RS13240HHJ99_RS13255HHJ99_RS13260HHJ99_RS13265HHJ99_RS13270HHJ99_RS13275HHJ99_RS13280HHJ99_RS13285HHJ99_RS13290HHJ99_RS13245HHJ99_RS13250HHJ99_RS13295
Location: 16085..16180 (96 bp)
Type: Others
Protein ID: WP_002441941.1
Location: 17793..18131 (339 bp)
Type: Others
Protein ID: WP_002436858.1
Location: 18350..19846 (1497 bp)
Type: Others
Protein ID: WP_170081014.1
Location: 20198..20332 (135 bp)
Type: Others
Protein ID: WP_002436888.1
Location: 20704..20952 (249 bp)
Type: Antitoxin
Protein ID: WP_176746841.1
Location: 20949..21287 (339 bp)
Type: Toxin
Protein ID: WP_002436882.1
Location: 21910..22584 (675 bp)
Type: Others
Protein ID: WP_145376072.1
Location: 22874..24118 (1245 bp)
Type: Others
Protein ID: WP_145376082.1
Location: 24393..25534 (1142 bp)
Type: Others
Protein ID: WP_152333551.1
Location: 16448..16966 (519 bp)
Type: Others
Protein ID: WP_002441943.1
Location: 17055..17690 (636 bp)
Type: Others
Protein ID: WP_170081013.1
Location: 25793..26044 (252 bp)
Type: Others
Protein ID: WP_170081015.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
HHJ99_RS1324016085..16180+96WP_002441941.1type I toxin-antitoxin system Fst family toxin-
HHJ99_RS1324516448..16966-519WP_002441943.1type 1 glutamine amidotransferase-
HHJ99_RS1325017055..17690-636WP_170081013.13-hexulose-6-phosphate synthase-
HHJ99_RS1325517793..18131+339WP_002436858.1helix-turn-helix transcriptional regulator-
HHJ99_RS1326018350..19846+1497WP_170081014.1malate dehydrogenase (quinone)-
HHJ99_RS1326520198..20332+135WP_002436888.1beta-class phenol-soluble modulin-
HHJ99_RS1327020704..20952+249WP_176746841.1AbrB family transcriptional regulatorAntitoxin
HHJ99_RS1327520949..21287+339WP_002436882.1type II toxin-antitoxin system PemK/MazF family toxinToxin
HHJ99_RS1328021910..22584+675WP_145376072.1IS6 family transposase-
HHJ99_RS1328522874..24118+1245WP_145376082.1aminoacyltransferase-
HHJ99_RS1329024393..25534+1142WP_152333551.1IS3 family transposase-
HHJ99_RS1329525793..26044-252WP_170081015.1DUF334 domain-containing protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideNon-Mobilizable plasmidblaZ-1..4125241252


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-108)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 113 a.a.        Molecular weight: 13019.98 Da        Isoelectric Point: 6.9772

>T154596 WP_002436882.1 NZ_CP051645:20949-21287 [Staphylococcus caprae]
MSIKQFDILYIDLDPTRGREKQKIRPCLVVNNQMTINGTDFVWILPITSREVRFPTDIEVKTKNGLVTGVIDTIQIRSLD
LNARYHNYKDELQDNLKNDVIQAIQTYLNPTL

Download         Length: 339 bp

>T154596 NZ_CP068155:56885-56992 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGACTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGGATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9248.43 Da        Isoelectric Point: 5.2090

>AT154596 WP_176746841.1 NZ_CP051645:20704-20952 [Staphylococcus caprae]
INKTSERIFKSGNSKAISLSKQTIQLADFEVGDKVEVQEMNGGLFIKKKEESIKDKITNFFKNGGKYTEEEIDFGESVGR
EI

Download         Length: 249 bp

>AT154596 NZ_CP068155:c56838-56772 [Escherichia coli]
TGTCTGGTTTCAAGATTAGCCCCCGTTTTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A1S1GRQ5

Antitoxin

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Source
ID
Structure
No matching records found

References