Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pemIK/MazF-doc
Location 20704..21287 Replicon plasmid pSY333-41
Accession NZ_CP051645
Organism Staphylococcus caprae strain SY333

Toxin (Protein)


Gene name pemK Uniprot ID A0A1S1GRQ5
Locus tag HHJ99_RS13275 Protein ID WP_002436882.1
Coordinates 20949..21287 (+) Length 113 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID -
Locus tag HHJ99_RS13270 Protein ID WP_176746841.1
Coordinates 20704..20952 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HHJ99_RS13240 16085..16180 + 96 WP_002441941.1 type I toxin-antitoxin system Fst family toxin -
HHJ99_RS13245 16448..16966 - 519 WP_002441943.1 type 1 glutamine amidotransferase -
HHJ99_RS13250 17055..17690 - 636 WP_170081013.1 3-hexulose-6-phosphate synthase -
HHJ99_RS13255 17793..18131 + 339 WP_002436858.1 helix-turn-helix transcriptional regulator -
HHJ99_RS13260 18350..19846 + 1497 WP_170081014.1 malate dehydrogenase (quinone) -
HHJ99_RS13265 20198..20332 + 135 WP_002436888.1 beta-class phenol-soluble modulin -
HHJ99_RS13270 20704..20952 + 249 WP_176746841.1 AbrB family transcriptional regulator Antitoxin
HHJ99_RS13275 20949..21287 + 339 WP_002436882.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
HHJ99_RS13280 21910..22584 + 675 WP_145376072.1 IS6 family transposase -
HHJ99_RS13285 22874..24118 + 1245 WP_145376082.1 aminoacyltransferase -
HHJ99_RS13290 24393..25534 + 1142 WP_152333551.1 IS3 family transposase -
HHJ99_RS13295 25793..26044 - 252 WP_170081015.1 DUF334 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid blaZ - 1..41252 41252


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-108)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 113 a.a.        Molecular weight: 13019.98 Da        Isoelectric Point: 6.9772

>T154596 WP_002436882.1 NZ_CP051645:20949-21287 [Staphylococcus caprae]
MSIKQFDILYIDLDPTRGREKQKIRPCLVVNNQMTINGTDFVWILPITSREVRFPTDIEVKTKNGLVTGVIDTIQIRSLD
LNARYHNYKDELQDNLKNDVIQAIQTYLNPTL

Download         Length: 339 bp

>T154596 NZ_CP068155:56885-56992 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGACTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGGATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9248.43 Da        Isoelectric Point: 5.2090

>AT154596 WP_176746841.1 NZ_CP051645:20704-20952 [Staphylococcus caprae]
INKTSERIFKSGNSKAISLSKQTIQLADFEVGDKVEVQEMNGGLFIKKKEESIKDKITNFFKNGGKYTEEEIDFGESVGR
EI

Download         Length: 249 bp

>AT154596 NZ_CP068155:c56838-56772 [Escherichia coli]
TGTCTGGTTTCAAGATTAGCCCCCGTTTTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1S1GRQ5

Antitoxin

Source ID Structure

References