Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-doc
Location 29727..30382 Replicon plasmid pSY333-92
Accession NZ_CP051644
Organism Staphylococcus caprae strain SY333

Toxin (Protein)


Gene name doc Uniprot ID -
Locus tag HHJ99_RS12750 Protein ID WP_170080926.1
Coordinates 29727..30125 (-) Length 133 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID -
Locus tag HHJ99_RS12755 Protein ID WP_170080925.1
Coordinates 30140..30382 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HHJ99_RS12730 24871..25590 - 720 WP_170080930.1 hypothetical protein -
HHJ99_RS12735 27041..27577 - 537 WP_170080929.1 hypothetical protein -
HHJ99_RS12740 27671..27982 - 312 WP_170080928.1 hypothetical protein -
HHJ99_RS12745 28653..29180 - 528 WP_170080927.1 hypothetical protein -
HHJ99_RS12750 29727..30125 - 399 WP_170080926.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
HHJ99_RS12755 30140..30382 - 243 WP_170080925.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
HHJ99_RS12760 30537..31154 - 618 WP_170080924.1 hypothetical protein -
HHJ99_RS12765 31782..31976 - 195 WP_170080923.1 helix-turn-helix transcriptional regulator -
HHJ99_RS12770 31982..32314 - 333 WP_170080922.1 hypothetical protein -
HHJ99_RS12775 32339..32956 - 618 WP_170080940.1 hypothetical protein -
HHJ99_RS12780 33718..34533 - 816 WP_170080941.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..91820 91820


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Death on curing protein

(2-131)

Antitoxin

SpoVT-AbrB domain

(10-51)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 15085.40 Da        Isoelectric Point: 7.3100

>T154595 WP_170080926.1 NZ_CP051644:c30125-29727 [Staphylococcus caprae]
MQYLTEKDIITLNVYVISKYSPKEQQGVKDPNALNMLVNMPKQYVFGHEVYDTLELKAASLVYNLVQKHVFFNGNKRTAL
LSLGVFLNMNGYQLTASNIEAADYMVKIATNDLQESDIEKWIKGHIKPIDNK

Download         Length: 399 bp

>T154595 NZ_CP068154:c68024-67863 [Escherichia coli]
ATGAAACTACCGGGAAACGCCCTTATCTGGTGCGTATTAATCGTGTGCTGCACGTTGTTGATATTCACACTCCTGACCCG
GAATCGTCTGTGCGAAGTCCGGCTGAAGGACGGATACAGGGAAGTTACGGCAACAATGGCTTACGAATCCGGCGGTAAGT
AG

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8841.11 Da        Isoelectric Point: 4.5408

>AT154595 WP_170080925.1 NZ_CP051644:c30382-30140 [Staphylococcus caprae]
MAVVNTRKLRKIGNSKVVTMPEEVIKALDIEEGQSIAFNVVNGQVVLEAVKVDDNESDILNIADQISKQYDSALKDLVNR

Download         Length: 243 bp

>AT154595 NZ_CP068154:c68275-68070 [Escherichia coli]
CCCGTGAATTGGCTGAACGACCGGATTATTTTCAGGGAAAGTGAGTGTGGTCAGTGTGCAGGTATATGGGCTATGATGTG
CCCGGCGCTTGAGGCTTTCTGCCTCATGACGTGAAGGTGGTTTGTTACAGTGTTGTGTGGCAGAAGGACAAAAGCCCCGT
AGTTAATTTTTCATTAACCCACGAGGCCTCTGCATGTCTAGTCCAC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References