Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-doc
Location 3640..4295 Replicon plasmid pSY333-92
Accession NZ_CP051644
Organism Staphylococcus caprae strain SY333

Toxin (Protein)


Gene name doc Uniprot ID -
Locus tag HHJ99_RS12605 Protein ID WP_170080926.1
Coordinates 3897..4295 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID -
Locus tag HHJ99_RS12600 Protein ID WP_170080925.1
Coordinates 3640..3882 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HHJ99_RS12570 130..303 + 174 WP_170080919.1 hypothetical protein -
HHJ99_RS12575 1066..1254 + 189 WP_170080920.1 hypothetical protein -
HHJ99_RS12580 1478..1684 + 207 WP_170080921.1 hypothetical protein -
HHJ99_RS12585 1709..2041 + 333 WP_170080922.1 hypothetical protein -
HHJ99_RS12590 2047..2241 + 195 WP_170080923.1 helix-turn-helix transcriptional regulator -
HHJ99_RS12595 2869..3486 + 618 WP_170080924.1 hypothetical protein -
HHJ99_RS12600 3640..3882 + 243 WP_170080925.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
HHJ99_RS12605 3897..4295 + 399 WP_170080926.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
HHJ99_RS12610 4842..5369 + 528 WP_170080927.1 hypothetical protein -
HHJ99_RS12615 6040..6351 + 312 WP_170080928.1 hypothetical protein -
HHJ99_RS12620 6445..6981 + 537 WP_170080929.1 hypothetical protein -
HHJ99_RS12625 8432..9151 + 720 WP_170080930.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..91820 91820


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Death on curing protein

(2-131)

Antitoxin

SpoVT-AbrB domain

(10-51)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 15085.40 Da        Isoelectric Point: 7.3100

>T154594 WP_170080926.1 NZ_CP051644:3897-4295 [Staphylococcus caprae]
MQYLTEKDIITLNVYVISKYSPKEQQGVKDPNALNMLVNMPKQYVFGHEVYDTLELKAASLVYNLVQKHVFFNGNKRTAL
LSLGVFLNMNGYQLTASNIEAADYMVKIATNDLQESDIEKWIKGHIKPIDNK

Download         Length: 399 bp

>T154594 NZ_CP068153:71745-72020 [Escherichia coli]
ATGGAACTGAAGTGGACCAGTAAGGCGCTTTCTGATTTGGCGCGGTTATATGATTTTCTGGTGCTGGCCAGTAAACCTGC
GGCCGCCAGAACGGTGCAGTCCCTGACACAGGCTCCGGTCATTCTGTTAACTCATCCACGTATGGGGGAACAGTTATTTC
AGTTTGAACCCAGGGAGGTCAGACGGATTTTTGCTGGCGAGTACGAAATCCGTTACGAACTTACTGGCCAGACTATTTAT
GTATTGCGCCTGTGGCACACACGAGAAAACAGGTAG

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8841.11 Da        Isoelectric Point: 4.5408

>AT154594 WP_170080925.1 NZ_CP051644:3640-3882 [Staphylococcus caprae]
MAVVNTRKLRKIGNSKVVTMPEEVIKALDIEEGQSIAFNVVNGQVVLEAVKVDDNESDILNIADQISKQYDSALKDLVNR

Download         Length: 243 bp

>AT154594 NZ_CP068153:71461-71745 [Escherichia coli]
ATGCAAATGAAAAACAATACCGCACAGGCAACAAAAGTAATTACCGCGCATGTGCCATTACCTATGGCTAATAAAGTCGA
CCAGATGGCCGCCAGACTGGAACGCTCCCGGGGCTGGATTATCAAACAGGCGCTTTCTGCATGGCTTGCCCAGGAGGAGG
AGCGTAATCGCCTGACGCTGGAAGCCCTGGACGATGTGACATCCGGACAGGTTATCGACCATCAGGCTGTACAGGCCTGG
GCGGACAGCCTCAGTACTGACAATCCGTTACCGGTGCCACGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References