Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 1226469..1226945 Replicon chromosome
Accession NZ_CP051643
Organism Staphylococcus caprae strain SY333

Toxin (Protein)


Gene name TsaT Uniprot ID C5QQH5
Locus tag HHJ99_RS06055 Protein ID WP_002441631.1
Coordinates 1226757..1226945 (+) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID C5QQH6
Locus tag HHJ99_RS06050 Protein ID WP_002441634.1
Coordinates 1226469..1226726 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HHJ99_RS06015 1221692..1222414 - 723 WP_002441649.1 type I 3-dehydroquinate dehydratase -
HHJ99_RS06020 1222584..1223006 + 423 WP_002441647.1 organic hydroperoxide resistance protein -
HHJ99_RS06025 1223401..1223907 + 507 WP_002441644.1 GNAT family N-acetyltransferase -
HHJ99_RS06030 1224105..1224725 + 621 WP_002441642.1 LysE family transporter -
HHJ99_RS06035 1224787..1225371 - 585 WP_037541214.1 phosphoglycerate mutase family protein -
HHJ99_RS06040 1225595..1225831 + 237 WP_002441638.1 hypothetical protein -
HHJ99_RS06045 1225823..1226026 - 204 WP_002441635.1 sterile alpha motif-like domain-containing protein -
HHJ99_RS06050 1226469..1226726 + 258 WP_002441634.1 hypothetical protein Antitoxin
HHJ99_RS06055 1226757..1226945 + 189 WP_002441631.1 hypothetical protein Toxin
HHJ99_RS06060 1227171..1227755 + 585 WP_037541212.1 orthopoxovirus protein, PF05708 family -
HHJ99_RS06065 1227819..1228052 - 234 WP_002441627.1 hypothetical protein -
HHJ99_RS06070 1228194..1228799 - 606 WP_002441625.1 GNAT family N-acetyltransferase -
HHJ99_RS06075 1228980..1229726 + 747 WP_044466334.1 poly-gamma-glutamate hydrolase family protein -
HHJ99_RS06080 1229847..1230131 + 285 WP_002441619.1 hypothetical protein -
HHJ99_RS06085 1230160..1230378 + 219 WP_002441617.1 hypothetical protein -
HHJ99_RS06090 1230680..1231006 + 327 WP_002441615.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(32-145)

Antitoxin

Vibrio phage ICP1, Orf50

(14-87)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7214.94 Da        Isoelectric Point: 9.7844

>T154592 WP_002441631.1 NZ_CP051643:1226757-1226945 [Staphylococcus caprae]
MNLHFQILLWLSIIFIVAGAIILAIMLKTKKEERKESYLGFTVIFLIFGFAMLIYTFIFGIL

Download         Length: 189 bp

>T154592 NZ_CP068152:c3910013-3909501 [Proteus mirabilis]
ATGACATTGAAGCTAACAGCACCTGAACCACTCAAATCAGTCCATCTGCTGGAGGGTTTTTCCTCCGGAGAAGAGGCTTT
AGATCTCTGGCTAAAAAACCGGGCAATGAGTAATCAAAACTCTGGTGCGTCGCGCACTTTTGTGACCACTTCGGATAACC
AGGTAATGGGGTATTATGCCTTGTCCACAGGGGTCATAAGCACCAATCAAGCCGTTGGTCGATTCCGCCGTAATATGCCC
ACCGACATACCCGTCATTCTACTTGGCAGGCTGGCGGTTGATACAAGGGCTAAAGGTCTTGGGATCGGAAGAGGACTTGT
TAAGGATGCCTGTCATCGCGTTATTCAGGCATCAGGGCTGGTGGGCATTAGAGGGGTGGTGGTTCACGCCCTTACTGACG
ATGCAAAACGGTTCTATGAGCATATTGGCTTCTTGCCTTCGCCGCTCGACCCGATGATGCTGATGATAACGCTTAGCGAT
CTGCAACTCGCTATGGGCATTTCCCCGAACTGA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9735.80 Da        Isoelectric Point: 4.0612

>AT154592 WP_002441634.1 NZ_CP051643:1226469-1226726 [Staphylococcus caprae]
MKIISVNVINIILTVLFIAFNVLITYNANVDNHLWLIPGLCICGIALFTSLTIAIIYTDLLSEILFFINIVLALYYIYPI
FYDFL

Download         Length: 258 bp

>AT154592 NZ_CP068152:c3910297-3910010 [Proteus mirabilis]
ATGCCAACTCAAAATGATGTGAGCGTAACACGTTCATCACTGAACCTGAGAATAAAGCCGGAAGATAAAATTCTGATCGA
CCGTGCCGCTAATGCAGTGGGGAAAAACCGTACCGAGTTTGTTCTGGAAGCTGCTCGACGTGCAGCTGAAGAAACGCTGG
CAGATCTGCGAGTCATTAACGTCAGTCCCGAAGTTTACCAGGAATTTATTAGCCAGCTTGATTCAGCGCCTGAGAGCAAT
GAGGCACTACGAAAAACAATGATGTCTAAATCCCCTTGGGAGAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1S1GRH8

Antitoxin

Source ID Structure
AlphaFold DB A0A1S1GRF3

References