Detailed information of TA system TA154591

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tsbAT/-
• Location: 211732..212535
• Replicon: chromosome
• Accession: NZ_CP051643
• Organism: Staphylococcus caprae strain SY333

Toxin (Protein)

• Gene name: tsbT
• Uniprot ID: C5QTI8
• Locus tag: HHJ99_RS01220
• Protein ID: WP_002443566.1
• Coordinates: 212356..212535 (+)
• Length: 60 a.a.

Antitoxin (Protein)

• Gene name: tsbA
• Uniprot ID: -
• Locus tag: HHJ99_RS01215
• Protein ID: WP_037541523.1
• Coordinates: 211732..212331 (+)
• Length: 200 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HHJ99_RS01195	207620..209077	+	1458	WP_049402038.1	ABC transporter substrate-binding protein/permease	-
HHJ99_RS01200	209070..209792	+	723	WP_002443573.1	amino acid ABC transporter ATP-binding protein	-
HHJ99_RS01205	209952..211079	+	1128	WP_002443571.1	tRNA epoxyqueuosine(34) reductase QueG	-
HHJ99_RS01210	211082..211552	+	471	WP_002443570.1	tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL	-
HHJ99_RS01215	211732..212331	+	600	WP_037541523.1	glucosamine-6-phosphate isomerase	Antitoxin
HHJ99_RS01220	212356..212535	+	180	WP_002443566.1	hypothetical protein	Toxin
HHJ99_RS01225	212771..213169	+	399	WP_002443564.1	hypothetical protein	-
HHJ99_RS01230	213322..214707	+	1386	WP_002443562.1	class II fumarate hydratase	-
HHJ99_RS01235	214807..215634	-	828	WP_049402039.1	RluA family pseudouridine synthase	-
HHJ99_RS01240	215813..216925	+	1113	WP_002443558.1	GAF domain-containing sensor histidine kinase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Glucosamine-6-phosphate isomerase (125-195)

Sequences

Toxin

Protein

• Length: 60 a.a.
• Molecular weight: 6967.41 Da
• Isoelectric Point: 3.9152

>T154591 WP_002443566.1 NZ_CP051643:212356-212535 [Staphylococcus caprae]
MAKEQESKLNYHEEENAMVTDLDDLKELGKEMEQISEENDEDKLNQSHDEDVRSDLQDK

Nucleotide

• Length: 180 bp

>T154591 NZ_CP068152:3174185-3174370 [Proteus mirabilis]
TTGAAAAGTTCGGAACTGATTAAGTTGTTAGAAAAAAACGGATGGATACTTGATAGAATAAAAGGAAGTCATCATCAATT
TACTCACCCTGATTTTTCTTTTGTTGTAACAGTACCGCATCCAAGAAAAGATTTAAAAAAAGGAACATTAAATCAAATTA
TTAAAAGTGCCAAACTGAAAAATTAA

Antitoxin

Protein

• Length: 200 a.a.
• Molecular weight: 22694.63 Da
• Isoelectric Point: 4.7838

>AT154591 WP_037541523.1 NZ_CP051643:211732-212331 [Staphylococcus caprae]
MAMNFKVFDNNERVAEYAADIIRKQFNNNPTTIAGFHLDKDQAPVLDELKKNVDTHAVDFSQINILDYDDNRSYYEALGV
PESQVYSISYEKDAIEFISDKMKTKENKGKLILQVLSIDESGKLDVSVRQGLMEAREIFLVVTGSNKRDVIEKLYRENGK
SSYEPADLKAHRMVNVILDKEAAAGLPEDVKEYFTARFV

Nucleotide

• Length: 600 bp

>AT154591 NZ_CP068152:3174417-3174830 [Proteus mirabilis]
ATGTTATATCCAGCCTTTATTGAAATTGATGAAGATGGTAGCGCAAGTGGCTGGTTCCCTGATATTGATGGTTGCATCTT
TGCGGGGGACAGTATTGAAGAAGCTCACGCAGATGCGAGGAGCGCTATTGATGCCCATTTTGAATTGTTAAGCGAGAAGG
GTTTAGATATCCCCTCTCCAAAATCTCAACAAGAGCATTTAATTAATTCTAGTGGTGATTACAATAATGGAATATGGCTT
TTAGTTGATGTTGATATGGATAAATACGACGGACGAGCAGAGCGTATTAATATCACATTGCCACATCGATTATTGAGTCG
CATCGATACTATCGTAAAAACAAATCCTGAATATGGGAGTCGTAGCGGATTTATTGCCACAGCAACCCGTAAAGAACTCC
AAAAGAATATTTAA

Structures

Toxin

• AlphaFold DB: A0A1J3ZT52