Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 51035..51564 Replicon chromosome
Accession NZ_CP051643
Organism Staphylococcus caprae strain SY333

Toxin (Protein)


Gene name mazF Uniprot ID C5QLA1
Locus tag HHJ99_RS00290 Protein ID WP_002445525.1
Coordinates 51202..51564 (+) Length 121 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag HHJ99_RS00285 Protein ID WP_049401954.1
Coordinates 51035..51205 (+) Length 57 a.a.

Genomic Context

HHJ99_RS00260HHJ99_RS00265HHJ99_RS00270HHJ99_RS00275HHJ99_RS00280HHJ99_RS00285HHJ99_RS00290HHJ99_RS00295HHJ99_RS00300HHJ99_RS00305HHJ99_RS00310
Location: 46850..47329 (480 bp)
Type: Others
Protein ID: WP_044466354.1
Location: 47322..48821 (1500 bp)
Type: Others
Protein ID: WP_044466353.1
Location: 48808..49350 (543 bp)
Type: Others
Protein ID: WP_044466352.1
Location: 49365..49721 (357 bp)
Type: Others
Protein ID: WP_044466351.1
Location: 49799..50947 (1149 bp)
Type: Others
Protein ID: WP_002445529.1
Location: 51035..51205 (171 bp)
Type: Antitoxin
Protein ID: WP_049401954.1
Location: 51202..51564 (363 bp)
Type: Toxin
Protein ID: WP_002445525.1
Location: 51936..52937 (1002 bp)
Type: Others
Protein ID: WP_044466350.1
Location: 53040..53366 (327 bp)
Type: Others
Protein ID: WP_037541852.1
Location: 53368..53847 (480 bp)
Type: Others
Protein ID: WP_002445522.1
Location: 53822..54592 (771 bp)
Type: Others
Protein ID: WP_002445521.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
HHJ99_RS0026046850..47329+480WP_044466354.1PH domain-containing protein-
HHJ99_RS0026547322..48821+1500WP_044466353.1PH domain-containing protein-
HHJ99_RS0027048808..49350+543WP_044466352.1PH domain-containing protein-
HHJ99_RS0027549365..49721+357WP_044466351.1holo-ACP synthase-
HHJ99_RS0028049799..50947+1149WP_002445529.1alanine racemase-
HHJ99_RS0028551035..51205+171WP_049401954.1hypothetical proteinAntitoxin
HHJ99_RS0029051202..51564+363WP_002445525.1type II toxin-antitoxin system PemK/MazF family toxinToxin
HHJ99_RS0029551936..52937+1002WP_044466350.1PP2C family protein-serine/threonine phosphatase-
HHJ99_RS0030053040..53366+327WP_037541852.1anti-sigma factor antagonist-
HHJ99_RS0030553368..53847+480WP_002445522.1anti-sigma B factor RsbW-
HHJ99_RS0031053822..54592+771WP_002445521.1RNA polymerase sigma factor SigB-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-109)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13511.68 Da        Isoelectric Point: 10.0250

>T154590 WP_002445525.1 NZ_CP051643:51202-51564 [Staphylococcus caprae]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTYLSESKMKEVDNALDISLGLHNFDHPKS

Download         Length: 363 bp

>T154590 NZ_CP068152:c1471226-1470657 [Proteus mirabilis]
ATGACAAACTATACTGTTTTGCTTGATGCCTGTGTCATGTATCCAGCCCCTCTTAGAAGTTATTTAATGTATCTTGCTAA
TACTGGTTTATTTAGAGCACGTTGGAGTAATCAGATCCATGATGAATGGATCACTAATTTATTAGTCAACAATCCAACAT
TAACAGCTGAGCGACTAATACGAACCAGAGATTTAATGAATGCACATGTTCCTGATTGTTTAGTAGAAGGCTACGAACCG
CTTATTTGTGGTTTAAAGCTACCTGATCCTAATGATCGTCATGTGCTAGCAGCAGCAATAAAAGGGCAGGCTCAAGCTAT
AATTACATTTAACTTAAAAGATTTTCCGCAAAAATACCTTAATTCTTTTGATATTTCAGCTATCCATCCTGATGAATTTT
TGAGTGACATGTTTGAATTAAATCCTAGTAGCTGTATTAAAGCGGCGCAACAACATAGACAAAGCCTAAAGAATCCACCA
ATGACCGTAGAGACCTTTTTAGGCTGTTTACAAAAGCAGAAATTACCCCAGTTTATTTCCCATTTACGGGCATTCCAGAT
ATTATTATAA

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6360.01 Da        Isoelectric Point: 4.1929

>AT154590 WP_049401954.1 NZ_CP051643:51035-51205 [Staphylococcus caprae]
MLSFNQNRRHSLEQSLKEGYAQMADLNLSLATEAFPIECEACDCNETYLTSNSKNE

Download         Length: 171 bp

>AT154590 NZ_CP068152:c1471678-1471226 [Proteus mirabilis]
ATGAATACGATAAGTGAGAGACTTAGTGCTGAAGATATTGCATTAGCAAAATTAAGTAGCCAAGAGCTATCCGCTGTTAT
GGATATTAATGGCAAAACGCAGAAGCTATCCATTATAGATAAGACGGGTAATAATCATATTGTACAAATACCAAATAGTG
CATTACGCCTAATGATTGAAATTCTTACTCAACTAGGGCAAGGGAATACTGTTAGTATCACACCAATCCATGCTGAGCTA
ACGACACAGGAAGCGGCTGATATACTCAATATGTCCCGTCCTACATTTGTAAAATTATTAGATACACGAGCGATACCCTA
CTCTAGAAAAGGAAATCGTAGGAAAGTTGCTTATGCTGATATTGTTGCTTATAAAAATGAATTGGAGCAAAAACGACTTG
ATGCCCTTGCTGAATTATCGCAATTAGATCAAGAAATGGATATGGGGTATTAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A1S1GUI8

Antitoxin

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Source
ID
Structure
No matching records found

References