Detailed information of TA system TA154589

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): TsdAT/-
• Location: 39744..40257
• Replicon: chromosome
• Accession: NZ_CP051643
• Organism: Staphylococcus caprae strain SY333

Toxin (Protein)

• Gene name: TsdT
• Uniprot ID: -
• Locus tag: HHJ99_RS00230
• Protein ID: WP_172594642.1
• Coordinates: 40105..40257 (+)
• Length: 51 a.a.

Antitoxin (Protein)

• Gene name: TsdA
• Uniprot ID: A0A1S1GSV6
• Locus tag: HHJ99_RS00225
• Protein ID: WP_037541856.1
• Coordinates: 39744..40037 (+)
• Length: 98 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HHJ99_RS00200	34920..35714	+	795	WP_002445553.1	hydroxyethylthiazole kinase	-
HHJ99_RS00205	35715..36353	+	639	WP_002445552.1	thiamine phosphate synthase	-
HHJ99_RS00210	36442..37311	+	870	WP_049402029.1	membrane protein insertase YidC	-
HHJ99_RS00215	37378..38028	-	651	WP_044466356.1	HD domain-containing protein	-
HHJ99_RS00220	38088..39572	-	1485	WP_002445546.1	cardiolipin synthase	-
HHJ99_RS00225	39744..40037	+	294	WP_037541856.1	copper-sensing transcriptional repressor CsoR	Antitoxin
HHJ99_RS00230	40105..40257	+	153	WP_172594642.1	heavy-metal-associated domain-containing protein	Toxin
HHJ99_RS00235	40393..40530	+	138	WP_002445543.1	hypothetical protein	-
HHJ99_RS00240	40587..41798	-	1212	WP_002445542.1	rod shape-determining protein RodA	-
HHJ99_RS00245	42445..43515	+	1071	WP_037541855.1	D-alanine--D-alanine ligase	-
HHJ99_RS00250	43531..44886	+	1356	WP_002445538.1	UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Metal-sensitive transcriptional repressor (3-95)

Sequences

Toxin

Protein

• Length: 51 a.a.
• Molecular weight: 5770.63 Da
• Isoelectric Point: 4.2898

>T154589 WP_172594642.1 NZ_CP051643:40105-40257 [Staphylococcus caprae]
MLMERLQNMIGVYNVAIDSKVGEIKVEFDTPANLNSIEKEVYDSGYRILY

Nucleotide

• Length: 153 bp

>T154589 NZ_CP068152:c1012893-1012507 [Proteus mirabilis]
ATGGTTATTTATAAAACAAAGATGTTCAAAAATAGTTTCAAAAAAATAACGCTTACGAATGCAGAACTAATCGCTATCGC
TACCGAAGTCCTTGCAGGACAATTTGAGGCAGATCTAGGTGGTGGTGTTATCAAGAAACGTGCCTGTATCCAAGGAAAAG
GTAAAAGTAGCGGAATTAGAACAATTATATTTTATAAGCAAGGGAATAATTTATTCTTTGCTGATGGTTGGAAAAAATCG
AGTTTAAGCTCTAAAAAAACCAAAGAGATCACAGATGATGAACTTGAGTCCTATAAAGATCTAGCAAAAGATCTCTTCAA
TGCAAATCAAAATAAAATAGATAAAATGATTGCACTAGGCCTTTTAACAGAGGTTAAATATGACTGA

Antitoxin

Protein

• Length: 98 a.a.
• Molecular weight: 11078.60 Da
• Isoelectric Point: 6.8620

>AT154589 WP_037541856.1 NZ_CP051643:39744-40037 [Staphylococcus caprae]
VTENEKAHHSDQTKANLKSRLNRIEGQVRAINRMIEDDVYCDDVLTQIRATRSALNSVATKLLDHHMKSCIMNKVNNGAQ
EEAMEELLVTFQKLIKD

Nucleotide

• Length: 294 bp

>AT154589 NZ_CP068152:c1012514-1012194 [Proteus mirabilis]
ATGACTGATAAAATGAAAGAAATGCTAAAATTTGCACAAGAAATGGAAGATGCAGGAGTCACTGATGGCAGTACAACTAA
ACGTATTGCCGCCAGAATAAAAGCGAAAGAATTACAAGCTAAGTATAAACATCCTACCCCTATGACAGGTGAAGATATAA
AAAGGATCCGTGAGCAAAATAATATCTCTCAATCTTCCCTTGCTTTGATATTGAATATGACTAAAGAAAGCGTTTCTAAG
TGGGAAAGAAACGAAATTAAGCCCAATGGTGCAGCACTACGACTTCTTCATTTAATAGATAAAAAAATATTATTCATCTA
G

Structures

Antitoxin

• AlphaFold DB: A0A1S1GSV6