Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 39744..40257 Replicon chromosome
Accession NZ_CP051643
Organism Staphylococcus caprae strain SY333

Toxin (Protein)


Gene name TsdT Uniprot ID -
Locus tag HHJ99_RS00230 Protein ID WP_172594642.1
Coordinates 40105..40257 (+) Length 51 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID A0A1S1GSV6
Locus tag HHJ99_RS00225 Protein ID WP_037541856.1
Coordinates 39744..40037 (+) Length 98 a.a.

Genomic Context

HHJ99_RS00200HHJ99_RS00205HHJ99_RS00210HHJ99_RS00225HHJ99_RS00230HHJ99_RS00235HHJ99_RS00245HHJ99_RS00250HHJ99_RS00215HHJ99_RS00220HHJ99_RS00240
Location: 34920..35714 (795 bp)
Type: Others
Protein ID: WP_002445553.1
Location: 35715..36353 (639 bp)
Type: Others
Protein ID: WP_002445552.1
Location: 36442..37311 (870 bp)
Type: Others
Protein ID: WP_049402029.1
Location: 39744..40037 (294 bp)
Type: Antitoxin
Protein ID: WP_037541856.1
Location: 40105..40257 (153 bp)
Type: Toxin
Protein ID: WP_172594642.1
Location: 40393..40530 (138 bp)
Type: Others
Protein ID: WP_002445543.1
Location: 42445..43515 (1071 bp)
Type: Others
Protein ID: WP_037541855.1
Location: 43531..44886 (1356 bp)
Type: Others
Protein ID: WP_002445538.1
Location: 37378..38028 (651 bp)
Type: Others
Protein ID: WP_044466356.1
Location: 38088..39572 (1485 bp)
Type: Others
Protein ID: WP_002445546.1
Location: 40587..41798 (1212 bp)
Type: Others
Protein ID: WP_002445542.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
HHJ99_RS0020034920..35714+795WP_002445553.1hydroxyethylthiazole kinase-
HHJ99_RS0020535715..36353+639WP_002445552.1thiamine phosphate synthase-
HHJ99_RS0021036442..37311+870WP_049402029.1membrane protein insertase YidC-
HHJ99_RS0021537378..38028-651WP_044466356.1HD domain-containing protein-
HHJ99_RS0022038088..39572-1485WP_002445546.1cardiolipin synthase-
HHJ99_RS0022539744..40037+294WP_037541856.1copper-sensing transcriptional repressor CsoRAntitoxin
HHJ99_RS0023040105..40257+153WP_172594642.1heavy-metal-associated domain-containing proteinToxin
HHJ99_RS0023540393..40530+138WP_002445543.1hypothetical protein-
HHJ99_RS0024040587..41798-1212WP_002445542.1rod shape-determining protein RodA-
HHJ99_RS0024542445..43515+1071WP_037541855.1D-alanine--D-alanine ligase-
HHJ99_RS0025043531..44886+1356WP_002445538.1UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Metal-sensitive transcriptional repressor

(3-95)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5770.63 Da        Isoelectric Point: 4.2898

>T154589 WP_172594642.1 NZ_CP051643:40105-40257 [Staphylococcus caprae]
MLMERLQNMIGVYNVAIDSKVGEIKVEFDTPANLNSIEKEVYDSGYRILY

Download         Length: 153 bp

>T154589 NZ_CP068152:c1012893-1012507 [Proteus mirabilis]
ATGGTTATTTATAAAACAAAGATGTTCAAAAATAGTTTCAAAAAAATAACGCTTACGAATGCAGAACTAATCGCTATCGC
TACCGAAGTCCTTGCAGGACAATTTGAGGCAGATCTAGGTGGTGGTGTTATCAAGAAACGTGCCTGTATCCAAGGAAAAG
GTAAAAGTAGCGGAATTAGAACAATTATATTTTATAAGCAAGGGAATAATTTATTCTTTGCTGATGGTTGGAAAAAATCG
AGTTTAAGCTCTAAAAAAACCAAAGAGATCACAGATGATGAACTTGAGTCCTATAAAGATCTAGCAAAAGATCTCTTCAA
TGCAAATCAAAATAAAATAGATAAAATGATTGCACTAGGCCTTTTAACAGAGGTTAAATATGACTGA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11078.60 Da        Isoelectric Point: 6.8620

>AT154589 WP_037541856.1 NZ_CP051643:39744-40037 [Staphylococcus caprae]
VTENEKAHHSDQTKANLKSRLNRIEGQVRAINRMIEDDVYCDDVLTQIRATRSALNSVATKLLDHHMKSCIMNKVNNGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp

>AT154589 NZ_CP068152:c1012514-1012194 [Proteus mirabilis]
ATGACTGATAAAATGAAAGAAATGCTAAAATTTGCACAAGAAATGGAAGATGCAGGAGTCACTGATGGCAGTACAACTAA
ACGTATTGCCGCCAGAATAAAAGCGAAAGAATTACAAGCTAAGTATAAACATCCTACCCCTATGACAGGTGAAGATATAA
AAAGGATCCGTGAGCAAAATAATATCTCTCAATCTTCCCTTGCTTTGATATTGAATATGACTAAAGAAAGCGTTTCTAAG
TGGGAAAGAAACGAAATTAAGCCCAATGGTGCAGCACTACGACTTCTTCATTTAATAGATAAAAAAATATTATTCATCTA
G

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
No matching records found

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A1S1GSV6

References