Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicB-HicA
Location 1711589..1712234 Replicon chromosome
Accession NZ_CP051642
Organism Avibacterium paragallinarum strain ADL-AP01

Toxin (Protein)


Gene name hicA Uniprot ID A0A0F5ESB4
Locus tag HHJ56_RS07990 Protein ID WP_017805948.1
Coordinates 1711589..1711771 (+) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A0F5EU47
Locus tag HHJ56_RS07995 Protein ID WP_017805949.1
Coordinates 1711815..1712234 (+) Length 140 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HHJ56_RS07965 1707072..1708037 - 966 WP_035685202.1 hypothetical protein -
HHJ56_RS07970 1708015..1708347 - 333 WP_017805944.1 hypothetical protein -
HHJ56_RS07975 1708455..1709297 - 843 WP_168939948.1 phage antirepressor N-terminal domain-containing protein -
HHJ56_RS07980 1709623..1710774 - 1152 WP_168939949.1 type I restriction enzyme HsdR N-terminal domain-containing protein -
HHJ56_RS07985 1710906..1711499 - 594 WP_035685204.1 hypothetical protein -
HHJ56_RS07990 1711589..1711771 + 183 WP_017805948.1 type II toxin-antitoxin system HicA family toxin Toxin
HHJ56_RS07995 1711815..1712234 + 420 WP_017805949.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
HHJ56_RS08000 1712272..1714530 - 2259 WP_017805950.1 tape measure protein -
HHJ56_RS08005 1714527..1714679 - 153 WP_017805951.1 hypothetical protein -
HHJ56_RS08010 1714715..1715200 - 486 WP_017805952.1 hypothetical protein -
HHJ56_RS08015 1715200..1715628 - 429 WP_017805953.1 DUF3277 family protein -
HHJ56_RS08020 1715680..1716753 - 1074 WP_017805954.1 DUF3383 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1698440..1766219 67779


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(3-58)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(4-63)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 7001.21 Da        Isoelectric Point: 10.4722

>T154588 WP_017805948.1 NZ_CP051642:1711589-1711771 [Avibacterium paragallinarum]
MKYSEFLRYLLEQGCKVENTKRGSHRKVMLNGHQTVFPYHGSQEIGTGLVHKIKKDLKLK

Download         Length: 183 bp

>T154588 NZ_CP068152:724189-725502 [Proteus mirabilis]
ATGGCGAGTCTTGATGTATATATGAATGAATACTATGTGGGCATCTTTACTAAAAAAAGCTCAGGTGCGCATTCATTCCA
ATATACTGAAGATTGGGTTAATCAACCAGGAAGTCGTCCCATCTCTCTTTCGATGCCATTACAGCTTCAAGAATATCAAG
GAGACTGTGTCTATAATTTCTTTGATAATCTGTTACCTGATAATACTGAAATTAGAAATCGTATTGTGAGTCGCTATAAT
GCGAACTCAAATCAACCCTTTGACCTATTAGCGGCTATCGGTGCAGATACTGTTGGTGCATTAAGGTTACTTCCTAGTGG
CAGTACGCCTGCGGATATCAAAAAAATAGAATATCAAAAACTCAATGATATTGAGCTTGAAAAAATTCTACTAGGATATA
AATCCAATACTCCACTCGGTATGCTTAAAGAATATACTGATTTCAGAATTTCCATCGCTGGAGCACAAGAAAAAACGGCA
TTACTTTTAAAAGATAATCATTGGTGTGTGCCACATAATAACACACCAACTACCCATATTATTAAACTGCCAATTGGTGT
TATTGAAAGTCATTCTTATACAATGGATTTATCCAATAGTGTAGAAAATGAGTATCTTTGTACCTTAATTGCCAAAGAAT
TTGATCTTCCCGTCCCCCACTGCTCTATTATTAAAACAAAAAATGTTAAAGCGCTTGCTGTAGAACGTTTTGATAGAAAA
TATTCATCTGATAAATCGTGGATAATACGTTTACCTCAAGAAGATTTTTGCCAAATTTTAAATATACCTTCTGCGCTAAA
ATATGAAAATGAAGGAGGGCCTGGCATTATCGATATTATGAAATATTTACTTGGCTCATCAAATGCCGATCAAGATCGTT
TTCATTTTATGAAGGCACAAGTGCTATTTTGGCTTTTGGCTGCAACGGATGGACACGCAAAGAATTTTTCTGTTTTTATC
AACCAAGAAGGACGTTTCCATCTCACTCCCCTTTATGACATTATGTCCATCTATCCCAATTTCGGAGGACGAGGACTTAA
TCCACGAGATGCAAAACTTGCTATGGGATTAAAAGCAAGCCGAGGCAAAAAATACGCAATAGAACAAATTTTTCCTCGTC
ATTTCTACCAAACAGCTGAAGCTGTCGGTTTCGATCCTTCATTAATGAGCGATATTCTTCGTTATTTTTATCAAGAAATG
GACGATGTCATACAACGCGTAAAACAGCAATTACCCGAGGATTTCCCTTCTGAGATTAGCAATACAATATTAGATGGAAT
GAAAGCACGCGCTGTTAGATTAGCTAACATTTAG

Antitoxin


Download         Length: 140 a.a.        Molecular weight: 15815.31 Da        Isoelectric Point: 4.7276

>AT154588 WP_017805949.1 NZ_CP051642:1711815-1712234 [Avibacterium paragallinarum]
MLRYPVELKADDNGTFLVTFPDIPEAASVGEDIESALLEAEEGLETALEFYFDDKRPIPLPSKPQEGQYTVPLSLLRSLK
VLLLNEMLAQGVRKAEMARRLDVHMPQIDRLLDFRYPSKIDFVEKAFKKLGREIHLAVS

Download         Length: 420 bp

>AT154588 NZ_CP068152:723931-724188 [Proteus mirabilis]
ATGATCATAATTAATGCCTATCAACTCAGTGTGCATCTAAAAGATGTCCGATTAACAAAAAAACTGTCTCAAAGTAAAGT
CGCCCAAAAAGTAGGGATCCGACAAGATACCGTGTCCAATTTTGAACTTAATCCTAATTCCACCAAACTAGAAACCTTTT
TCAAACTGCTCTCCGCACTAAATTTAGAGATGGAAATTCATCCTAAAGATGCTAAAAATAATTTAGCACACAAAAGTGAA
TGGAAAGAGGAGTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0F5ESB4

Antitoxin

Source ID Structure
AlphaFold DB A0A0F5EU47

References