Detailed information of TA system TA154578

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YafQ-RelB
• Location: 1315364..1315951
• Replicon: chromosome
• Accession: NZ_CP051641
• Organism: Avibacterium paragallinarum strain ADL-AP02

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: HHJ57_RS06150
• Protein ID: WP_103846679.1
• Coordinates: 1315364..1315627 (-)
• Length: 88 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A3G8W4K1
• Locus tag: HHJ57_RS06155
• Protein ID: WP_035686016.1
• Coordinates: 1315661..1315951 (-)
• Length: 97 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HHJ57_RS06125	1310396..1311010	-	615	WP_046097415.1	Holliday junction branch migration protein RuvA	-
HHJ57_RS06130	1311098..1311658	-	561	WP_035685784.1	crossover junction endodeoxyribonuclease RuvC	-
HHJ57_RS06135	1311734..1312474	-	741	WP_035685786.1	YebC/PmpR family DNA-binding transcriptional regulator	-
HHJ57_RS06140	1312928..1313371	-	444	WP_035685789.1	dihydroneopterin triphosphate diphosphatase	-
HHJ57_RS06145	1313497..1315275	-	1779	WP_035685792.1	aspartate--tRNA ligase	-
HHJ57_RS06150	1315364..1315627	-	264	WP_103846679.1	type II toxin-antitoxin system YafQ family toxin	Toxin
HHJ57_RS06155	1315661..1315951	-	291	WP_035686016.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
HHJ57_RS06160	1316143..1316868	+	726	WP_035685795.1	carboxy-S-adenosyl-L-methionine synthase CmoA	-
HHJ57_RS06165	1316989..1317942	-	954	WP_168939935.1	porin	-
HHJ57_RS06170	1317887..1318069	-	183	WP_168939936.1	hypothetical protein	-
HHJ57_RS06175	1318292..1319359	-	1068	WP_046097416.1	porin	-
HHJ57_RS06180	1319632..1320744	-	1113	Protein_1187	porin	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, YafQ-like toxin (2-86)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-71)

Sequences

Toxin

Protein

• Length: 88 a.a.
• Molecular weight: 10200.10 Da
• Isoelectric Point: 9.1425

>T154578 WP_103846679.1 NZ_CP051641:c1315627-1315364 [Avibacterium paragallinarum]
MAKEFKRDLVQLAKKAPHLFVHPRYLEVMHCLTNGLTLPAEYKNHPLKNNLKGYMDCHILNDLVLIYKIEQQCLKLVRLN
THSEVFA

Nucleotide

• Length: 264 bp

>T154578 NZ_CP068149:101903-102214 [Serratia liquefaciens]
GTGCATGTAATTAGCAGACAGCCGTTTAACGAGGCTGCCGGAAAATACCCTAATAGCGCATTGGCGCTTCTGGATTTGAT
GCGGGTTCTGGAAAAAAAGACCTTCAACAGCCCGGATGAAATGAAAAGAGCGATCCCGTCACTGGATAACTTCAAGTACC
GTAAAAAGTGGTGGGTTATCGATGTGTCCGGCAATACGTTGCGGCTTATGGCCTTCATCGACTTTGAAAAGCAAAAGGTT
TTTGTTAAGCACATTGCGACTCATGCCGAATACGACAAGTTAACCAAGTATTATAGGGAGCATAAAGAATGA

Antitoxin

Protein

• Length: 97 a.a.
• Molecular weight: 10716.23 Da
• Isoelectric Point: 4.7185

>AT154578 WP_035686016.1 NZ_CP051641:c1315951-1315661 [Avibacterium paragallinarum]
MTNNNAVVNFRLPQHLKTEAFEVIAQYGLTPSQVFNMFLTEIATTKAIPLSLNYLQPNAKTLAAMNEIESGTAERFSLDD
KTDLATLLQQIAEEKK

Nucleotide

• Length: 291 bp

>AT154578 NZ_CP068149:102253-102654 [Serratia liquefaciens]
ATGATCGCGACATTTGCCAACGCGGTGAAATGCATTCCTCTGATGACGGGTGATAAAAGCGAGGCTGAATACAAAAAAGC
CCTTGAGCTGATTGAGTATCTTGTCGATCGCGACGAGCTGAGCAACCCGCTTTTTGAACCGCTTGCGGCCAAAATTACAG
AGTATGAAAACAGCGCCCCGGAATTTGAGGCGTTTAACCGCCGCTTGGCGGAGATCCCTACCGGGGTCGCCGCGTTGCGT
ACCCTGATGGATCAGCATGGTTTGAAAGCGGCTGATCTGGAAGATGAATTGGGGTCTAAAAGCAATGTCAGCAACATTCT
CAGTGGTCGCCGTGCGTTGACTGTGCAGCACATTAAGGCGCTGGCGACGCGTTTTGATGTCCCTGCTGATTTGTTTATCT
AA

Structures

Antitoxin

• AlphaFold DB: A0A3G8W4K1