Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 934789..935375 Replicon chromosome
Accession NZ_CP051641
Organism Avibacterium paragallinarum strain ADL-AP02

Toxin (Protein)


Gene name hicA Uniprot ID A0A3G8W1K6
Locus tag HHJ57_RS04425 Protein ID WP_035687070.1
Coordinates 934789..935037 (+) Length 83 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A3G8VZN0
Locus tag HHJ57_RS04430 Protein ID WP_035687072.1
Coordinates 935034..935375 (+) Length 114 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HHJ57_RS04410 930821..932020 + 1200 WP_035688521.1 tyrosine--tRNA ligase -
HHJ57_RS04415 932330..933259 + 930 WP_035688523.1 aminoimidazole riboside kinase -
HHJ57_RS04420 933278..934729 + 1452 WP_046097372.1 glycoside hydrolase family 32 protein -
HHJ57_RS04425 934789..935037 + 249 WP_035687070.1 type II toxin-antitoxin system HicA family toxin Toxin
HHJ57_RS04430 935034..935375 + 342 WP_035687072.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
HHJ57_RS04435 935470..935946 + 477 WP_035687075.1 tRNA (adenosine(37)-N6)-threonylcarbamoyltransferase complex ATPase subunit type 1 TsaE -
HHJ57_RS04440 935959..937206 + 1248 WP_035687078.1 N-acetylmuramoyl-L-alanine amidase -
HHJ57_RS04445 937215..939188 + 1974 WP_035687081.1 DNA mismatch repair endonuclease MutL -
HHJ57_RS04450 939197..940123 + 927 WP_035687084.1 tRNA (adenosine(37)-N6)-dimethylallyltransferase MiaA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(20-81)

Antitoxin

Uncharacterised protein family HicB

(54-102)


Sequences

Toxin        


Download         Length: 83 a.a.        Molecular weight: 9219.85 Da        Isoelectric Point: 10.2543

>T154577 WP_035687070.1 NZ_CP051641:934789-935037 [Avibacterium paragallinarum]
MGKSEKLLEKLANAKNTFIWTDLLTLLARLGYEKREMAGSRVRFYNAELDHLILLHKPHPENYIKGGALKSVKEGLKGAG
LL

Download         Length: 249 bp

>T154577 NZ_CP068148:c4708706-4708422 [Serratia liquefaciens]
ATGCGTGTCGAATGGGATGAAGAAGCGCTACGGGACAGGGAACGTATTTTTGATTTTCTCTATCCTTTTAATCCACAGGT
TGCTGAGCAGGCTGATGCTGAGATTGATAAGGCAGTGAAGCGCCTGTTGGATTACCCTGAACTCGGTAAAATTTGGTACA
GGCAGGCGCGTAAGTTATTGGTCAGCCAGGCTTCATTAATAGTTTTATACGTTGTTGTCGACGACGTGATTAAGGTTTTA
GCCGTTGTTCATCAACGAGAGAAATTCCCCGACATAGAGAACTAA

Antitoxin


Download         Length: 114 a.a.        Molecular weight: 12710.50 Da        Isoelectric Point: 4.5942

>AT154577 WP_035687072.1 NZ_CP051641:935034-935375 [Avibacterium paragallinarum]
MTLLKYKGYVGTIEADLENNVLFGKLAYIRDVITYEAETLPQLEKEFQTSVDLYLQDCQELGRTPDKPFKGVFNVRISEE
LHRNAVLAAGDLSLNAFVAEAIKEKVERAGITN

Download         Length: 342 bp

>AT154577 NZ_CP068148:c4709002-4708715 [Serratia liquefaciens]
ATGGAAAGCCGTATCCAGTTTCGTATTGAGGATGAGACTAAACGTTTGGCGCAGAAAGCCGCAGAAGCCAAGGGGATCAC
TTTGAGTGAGGCGTGTCGACGTTTGGCTGAGCAAATGGCGGATGAGCAACGGGCCACTGAGCAACATGAAAATTGGTTGA
AAGAAAAGGTTGATGCCGCTTTTGCCCGTTTGCATGAAGGAAGTGCGGTCTATCTTGACCAGCAACAGGTTGATGAAAGC
ATGGATGCCTTTAAGGCAAAAGTCCGAGCGAAATACGACCGAAAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3G8W1K6

Antitoxin

Source ID Structure
AlphaFold DB A0A3G8VZN0

References