Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumA-relB/COG3657-dnstrm_HI1420
Location 1476693..1477280 Replicon chromosome
Accession NZ_CP051640
Organism Avibacterium paragallinarum strain ADL-AP07

Toxin (Protein)


Gene name PumA Uniprot ID -
Locus tag HHJ58_RS06910 Protein ID WP_136711940.1
Coordinates 1476984..1477280 (-) Length 99 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag HHJ58_RS06905 Protein ID WP_017807324.1
Coordinates 1476693..1476983 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HHJ58_RS06865 1471693..1472499 - 807 WP_035689420.1 helix-turn-helix domain-containing protein -
HHJ58_RS06870 1472496..1473266 - 771 WP_046097539.1 phage regulatory protein/antirepressor Ant -
HHJ58_RS06875 1473376..1473783 + 408 WP_168939907.1 hypothetical protein -
HHJ58_RS06880 1473801..1474241 - 441 Protein_1329 hypothetical protein -
HHJ58_RS06885 1474289..1474495 - 207 WP_017807328.1 helix-turn-helix transcriptional regulator -
HHJ58_RS06890 1474633..1475286 + 654 WP_017807327.1 LexA family transcriptional regulator -
HHJ58_RS06895 1475286..1475771 + 486 WP_017807326.1 hypothetical protein -
HHJ58_RS06900 1475773..1476546 + 774 WP_017807325.1 DUF1828 domain-containing protein -
HHJ58_RS06905 1476693..1476983 - 291 WP_017807324.1 putative addiction module antidote protein Antitoxin
HHJ58_RS06910 1476984..1477280 - 297 WP_136711940.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HHJ58_RS06915 1477599..1477769 - 171 WP_017807323.1 DUF1508 domain-containing protein -
HHJ58_RS06920 1477784..1478005 + 222 WP_017806446.1 hypothetical protein -
HHJ58_RS06925 1478705..1479319 + 615 WP_168939992.1 polymer-forming cytoskeletal protein -
HHJ58_RS06930 1479413..1479721 + 309 WP_046097548.1 hypothetical protein -
HHJ58_RS06935 1479743..1480018 + 276 WP_035689243.1 hypothetical protein -
HHJ58_RS06940 1480008..1480469 + 462 WP_168939987.1 hypothetical protein -
HHJ58_RS06945 1480466..1480681 + 216 WP_168939988.1 hypothetical protein -
HHJ58_RS06955 1480896..1481837 + 942 WP_035689276.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - hlyB 1450922..1498939 48017


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-89)

Antitoxin

Cro/C1-type helix-turn-helix domain

(44-89)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11040.10 Da        Isoelectric Point: 10.5997

>T154570 WP_136711940.1 NZ_CP051640:c1477280-1476984 [Avibacterium paragallinarum]
MIQIKSTTLFKKWLDELKDLRARAKIQTRIKRLQLGNFGDVKPVGEGISELRITEGKGYRIYLKNQNGVVVILLCAGDKS
IQSKDIEKAKLLAKELGV

Download         Length: 297 bp

>T154570 NZ_CP068148:1154383-1154769 [Serratia liquefaciens]
ATGTATATGTTTGACACCAATACGGTCAGCCAACTGTTCCGTCGGCATCCCCGCTTGCTGAGCCTAATGGAAAAAATCCC
GCCTTCTGCGGTATGCATTTCCAGCATTACGCAGGCGGAACTGCTTTATGGCGTAGCCAAGCGGCAGAACCTTGCGCTGA
AAGCGACGGTCGCGGCATTTCTTGATTCCGTGACGGTATATGCCTGGGACAGTGAAGCCGCGCACTGCTATGGCACGCTG
CGGGCGGAAATGACGCAAAAGGGGCGGGTGATGGGGGCCCTGGATCAGCTAATTGCCGCCCACGCGCAGAGCCGCGGAGC
GACAATAGTGACTAACGACCGGGCGTTTGCCATGGTGCCAGGCCTGACGGTAGAAGACTGGACCTAG

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10812.39 Da        Isoelectric Point: 4.8550

>AT154570 WP_017807324.1 NZ_CP051640:c1476983-1476693 [Avibacterium paragallinarum]
MMELQDFDIAEHLRSEEEIQLYLNEVLQENDVDLILSALGDIAKARNMSQLAREVGVSREGLYKAFSGKGNPTFSTVLKV
MKALNLSFEVKRVTHA

Download         Length: 291 bp

>AT154570 NZ_CP068148:1154117-1154380 [Serratia liquefaciens]
ATGGAAAGGGTCGCGAAACTGTTTAAAAACGGCAGAAATCAGGCGGTGAGGTTACCCGTGGAATTCGAATTTGATACAGA
TCGTGTGTATATCCGCCGCGATCGGGAGGGAAACGTGATTTTATCTAAATATCCGGCCAAACCTGACAGCTGGGCTCCGC
TGCTGCAAATGATCGAAAAAACGCAGGTACCGCATGACTTTCTGGCGGCTGATGAACGTCAGCAGGGCAGTGCCACCCGC
GATCCGTTCGCCGGGGAAGAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References