Detailed information of TA system TA154569

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-DnaT
• Location: 1415497..1416037
• Replicon: chromosome
• Accession: NZ_CP051640
• Organism: Avibacterium paragallinarum strain ADL-AP07

Toxin (Protein)

• Gene name: relE
• Uniprot ID: A0A3G8VZS8
• Locus tag: HHJ58_RS06495
• Protein ID: WP_035688134.1
• Coordinates: 1415497..1415787 (-)
• Length: 97 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A3G8W1I3
• Locus tag: HHJ58_RS06500
• Protein ID: WP_035688131.1
• Coordinates: 1415777..1416037 (-)
• Length: 87 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HHJ58_RS06455	1411929..1412270	-	342	WP_035688146.1	hypothetical protein	-
HHJ58_RS06460	1412270..1412494	-	225	WP_035688166.1	hypothetical protein	-
HHJ58_RS06465	1412499..1412768	-	270	WP_035688144.1	hypothetical protein	-
HHJ58_RS06470	1412761..1412991	-	231	WP_035688141.1	hypothetical protein	-
HHJ58_RS06475	1412984..1413556	-	573	WP_051128102.1	ash family protein	-
HHJ58_RS06480	1413660..1413965	-	306	WP_035688139.1	hypothetical protein	-
HHJ58_RS06485	1413976..1414191	-	216	WP_035688136.1	helix-turn-helix domain-containing protein	-
HHJ58_RS06490	1414355..1415455	-	1101	WP_051128101.1	hypothetical protein	-
HHJ58_RS06495	1415497..1415787	-	291	WP_035688134.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
HHJ58_RS06500	1415777..1416037	-	261	WP_035688131.1	stability protein StbD	Antitoxin
HHJ58_RS06505	1416176..1417141	-	966	WP_035688129.1	P2 family phage major capsid protein	-
HHJ58_RS06510	1417153..1417830	-	678	WP_035688128.1	hypothetical protein	-
HHJ58_RS06515	1417834..1418040	-	207	WP_035688126.1	AlpA family phage regulatory protein	-
HHJ58_RS06520	1418320..1418469	+	150	WP_156127747.1	hypothetical protein	-
HHJ58_RS06525	1418700..1419911	-	1212	WP_035688123.1	tyrosine-type recombinase/integrase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-82)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 97 a.a.
• Molecular weight: 11399.31 Da
• Isoelectric Point: 10.6318

>T154569 WP_035688134.1 NZ_CP051640:c1415787-1415497 [Avibacterium paragallinarum]
MTYKLSFDKRALKEWHKLGDTLRQQFKAKLIERLENPHVLSDKLHGYQTLYKIKLRSAGYRLVYDVNDNEIRVIVLSVGK
REHLQAYKKALSRKAQ

Nucleotide

• Length: 291 bp

>T154569 NZ_CP068148:c849792-849448 [Serratia liquefaciens]
ATGTGGCAGATCGTGACCGTCGAACGATTCGACAGCTGGTTTTTATCATTAAACAGCGATCAACAAAAAAGCGTGCTGGT
AGGAATATTCAAACTGCAGGAATTCGGCCCCTTGTTGGCGCGTCCTCATGCCGACACGCTGAATCACAAAAACCAAATAC
AGCATCTGAAAGAGTTACGTATTCAGCATCGCGGTCGGCCGTTTCGGATTTTCTTCGCCTTCGATCCGCAACGACAAGCG
GCCCTGCTTTGCGGTGGCGATAAAACCGGTAATAAACGCTTCTATCAACAAATGTTGCCGATCGCCATCAGAGAGTTTCC
ACATTACTTGGCAACCCAGAGGTAA

Antitoxin

Protein

• Length: 87 a.a.
• Molecular weight: 9550.98 Da
• Isoelectric Point: 4.1813

>AT154569 WP_035688131.1 NZ_CP051640:c1416037-1415777 [Avibacterium paragallinarum]
MAIQQILTRHTASISDLKKNPMGIVSEGTEQEGAIAILNRNEPVFYCVNPCLFAVIQEILEDKELGELATQRLATLDPVE
VRLDDL

Nucleotide

• Length: 261 bp

>AT154569 NZ_CP068148:c849442-849140 [Serratia liquefaciens]
ATGGCCAAACCCTTATCAGATCTGATCGACAGACTCGATCCCACCGTAGTTGAAGCTGCGCAACAGAAAGCGGACAAAGA
AATTTTTGAACTGCGGCTGGCAATGCTTCGGGAAGAACTGGCGGTGTCTCAGGTGGAACTGGCCAAGCGGCTTGGTATCA
GCCAACCTTCGGTCGCCAACCTGGAAAAACGCGGCAGCGAAATTAAACTCTCTTCACTCAAACGCTATATCGAAGCCATG
GGGGGAACGCTGTCGCTGGAAGTTCAGCTCCCGAACGGCCAGCATCGACGGATGACGCTGTAA

Structures

Toxin

• AlphaFold DB: A0A3G8VZS8

Antitoxin

• AlphaFold DB: A0A3G8W1I3