Detailed information of TA system TA154567

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-couple_hipB
• Location: 1048349..1049982
• Replicon: chromosome
• Accession: NZ_CP051640
• Organism: Avibacterium paragallinarum strain ADL-AP07

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: A0A3G8W245
• Locus tag: HHJ58_RS04920
• Protein ID: WP_035684858.1
• Coordinates: 1048349..1049656 (+)
• Length: 436 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: -
• Locus tag: HHJ58_RS04925
• Protein ID: WP_081637498.1
• Coordinates: 1049656..1049982 (+)
• Length: 109 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HHJ58_RS04895	1043712..1044746	+	1035	WP_035684872.1	thiamine-phosphate kinase	-
HHJ58_RS04900	1044752..1045252	+	501	WP_017806513.1	phosphatidylglycerophosphatase A	-
HHJ58_RS04905	1045264..1045899	+	636	WP_035684869.1	LysE family transporter	-
HHJ58_RS04910	1045914..1046726	+	813	WP_035684866.1	4-hydroxy-tetrahydrodipicolinate reductase	-
HHJ58_RS04915	1048001..1048249	+	249	WP_035684861.1	2Fe-2S ferredoxin-like protein	-
HHJ58_RS04920	1048349..1049656	+	1308	WP_035684858.1	HipA domain-containing protein	Toxin
HHJ58_RS04925	1049656..1049982	+	327	WP_081637498.1	helix-turn-helix domain-containing protein	Antitoxin
HHJ58_RS04930	1050023..1051153	-	1131	WP_035684855.1	ribonucleotide-diphosphate reductase subunit beta	-
HHJ58_RS04935	1051316..1051738	-	423	WP_035684853.1	DUF1043 family protein	-
HHJ58_RS04940	1051873..1053642	-	1770	WP_035684851.1	30S ribosomal protein S12 methylthiotransferase accessory factor YcaO	-
HHJ58_RS04945	1053749..1054480	-	732	WP_035684848.1	class I SAM-dependent methyltransferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA-like, C-terminal (158-351)

Antitoxin

• Cro/C1-type helix-turn-helix domain (38-90)

Sequences

Toxin

Protein

• Length: 436 a.a.
• Molecular weight: 50363.28 Da
• Isoelectric Point: 5.6627

>T154567 WP_035684858.1 NZ_CP051640:1048349-1049656 [Avibacterium paragallinarum]
MEKLTLQTYIDQEWRDMAELHFEKETYQLSNLVYFPDYITQYFGQEGSRAVSINYPVHIFIENRKTLWSCIGDIAPAGAS
RRYWIESLDIKHLPESEQNYRLLKYGAISPVGNLRIKEATPQKTEVRYFDIEKVKDRQSDFLEYANQSGAMVGGATGAGG
EAPKLLLKRHNGKVWIDNLQDGKDQDISYLVKYPRGRYSPIDCDILRAEFHYYQEVAELGFDTIDIHHMCLEEGERYPSL
WLPRFDITKKEGKYNRLALESVYSMLQKQGGTLEHEVTIRQLIKIISASNLEFDQQHFVLEWVKRDLLNIAFGNSDNHGR
NMAFLRDEQKIWLAPIYDFAPMRADPEGIIRSTTWNRKGSLPQEFAGEYRFDLIAESLSDLIEPSLLLTELQQLAIRLVD
LKSRLAQRGVPQAILDHPSIGFDYLPEKLKAWGLV

Nucleotide

• Length: 1308 bp

>T154567 NZ_CP068148:c420611-420300 [Serratia liquefaciens]
ATGCATATAATTTCAAGGGAACCGTTCAACGAGGCCGCAATCCGCTACCCCAACGAAGCAGCCTCTCTCAACACAATCTA
CAAAACGCTGCGCCGGGGGACATTTCATACGCCGGAAGATTTAAAATCCCTTTTCCCCAGCCTGGACAGAATGAAGTACA
AAGCAAAATGGTGGGTCATTGATGTCGGAGGAAATCATCTCAGGATCTTATTCTTTGCCAGTTTTGATACCCAGAAAATA
TTTGTTAAACAGATAGTGACTCATGCAGAGTACGACAGATTACTGCAGCAGTACCGGAGGAACCCAAAATGA

Antitoxin

Protein

• Length: 109 a.a.
• Molecular weight: 12252.39 Da
• Isoelectric Point: 10.9810

>AT154567 WP_081637498.1 NZ_CP051640:1049656-1049982 [Avibacterium paragallinarum]
MITRKNASKVGATISTTERNNVRNRIIKALLLGKMTQGQALRKLRIEMLGVNQQQYMKVVKVSRQTLSNIENDKGNYSVE
TINQVFKPFGFELGLVPISKELLTEIMQ

Nucleotide

• Length: 327 bp

>AT154567 NZ_CP068148:c420303-419881 [Serratia liquefaciens]
ATGATCACCGATGCGCTTAAGGCCACCCATGAGCTGTTACGCGCCATACCCTTGTTAGGTGGCAGCACCTCGCCACAGGA
TTACCGTGATGCTCTGGCGTTAGTGGAACACCTGCTTGAAACCGACGAGCGCCACCCGCTGATTGACGTTCTGGCAGCCA
AGATCGTCGAGTATGAAGATAACAGCCCTGATTTTGCAGAGTTCAATCAGCGTATCGCACAGCTACCACAAGGTGTAGCC
GCGCTGAGCGTGCTGATGGAGCAATATGGCCTCAGTCAAAGCGACTTCGAAAAGGAGATCGGCAAAAAGTCACTGGTGAG
CCAAATTCTAAGCGGAAAGCGATCGCTGACCATCCCCCATATCATGGCGCTGGCAAAACGTTTCAACCTGCCGCCGGCCT
TGTTCTTGCCTGAAGCCCGTTAG

Structures

Toxin

• AlphaFold DB: A0A3G8W245