Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 808012..808598 Replicon chromosome
Accession NZ_CP051640
Organism Avibacterium paragallinarum strain ADL-AP07

Toxin (Protein)


Gene name hicA Uniprot ID A0A3G8W1K6
Locus tag HHJ58_RS03825 Protein ID WP_035687070.1
Coordinates 808350..808598 (-) Length 83 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A3G8VZN0
Locus tag HHJ58_RS03820 Protein ID WP_035687072.1
Coordinates 808012..808353 (-) Length 114 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HHJ58_RS03800 803264..804190 - 927 WP_035687084.1 tRNA (adenosine(37)-N6)-dimethylallyltransferase MiaA -
HHJ58_RS03805 804199..806172 - 1974 WP_035687081.1 DNA mismatch repair endonuclease MutL -
HHJ58_RS03810 806181..807428 - 1248 WP_035687078.1 N-acetylmuramoyl-L-alanine amidase -
HHJ58_RS03815 807441..807917 - 477 WP_035687075.1 tRNA (adenosine(37)-N6)-threonylcarbamoyltransferase complex ATPase subunit type 1 TsaE -
HHJ58_RS03820 808012..808353 - 342 WP_035687072.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
HHJ58_RS03825 808350..808598 - 249 WP_035687070.1 type II toxin-antitoxin system HicA family toxin Toxin
HHJ58_RS03830 808658..810109 - 1452 WP_046097372.1 glycoside hydrolase family 32 protein -
HHJ58_RS03835 810128..811057 - 930 WP_035688523.1 aminoimidazole riboside kinase -
HHJ58_RS03840 811367..812566 - 1200 WP_035688521.1 tyrosine--tRNA ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(20-81)

Antitoxin

Uncharacterised protein family HicB

(54-102)


Sequences

Toxin        


Download         Length: 83 a.a.        Molecular weight: 9219.85 Da        Isoelectric Point: 10.2543

>T154566 WP_035687070.1 NZ_CP051640:c808598-808350 [Avibacterium paragallinarum]
MGKSEKLLEKLANAKNTFIWTDLLTLLARLGYEKREMAGSRVRFYNAELDHLILLHKPHPENYIKGGALKSVKEGLKGAG
LL

Download         Length: 249 bp

>T154566 NZ_CP068148:c193982-193704 [Serratia liquefaciens]
GTGAAGCTAAAGTGGACGGATCCCACAATTGCTGACCGTATGGCAATTTATGACTATCTTGCGTCAAAGAACCCGATAGC
TGCCGCAGAGATTGATGCTTTGATTTCTGCGGCGGCAAGCCAACTATCCCGAAACCCATCAAGTGGCAAAGTGGGCCGGG
TTTCAGGTACACGTGAATGGGTCATTCATCATTTTTACCTACTGATTTATGAAGTAAAAAATGACCTTCTTATTATTTTG
GCAGTCGTACATTCCCGCCGGCAATGGCCAAAGGATTAA

Antitoxin


Download         Length: 114 a.a.        Molecular weight: 12710.50 Da        Isoelectric Point: 4.5942

>AT154566 WP_035687072.1 NZ_CP051640:c808353-808012 [Avibacterium paragallinarum]
MTLLKYKGYVGTIEADLENNVLFGKLAYIRDVITYEAETLPQLEKEFQTSVDLYLQDCQELGRTPDKPFKGVFNVRISEE
LHRNAVLAAGDLSLNAFVAEAIKEKVERAGITN

Download         Length: 342 bp

>AT154566 NZ_CP068148:c194269-194000 [Serratia liquefaciens]
ATGTCTGAATCTACCGTGGTTATCCGGGTGGATGACGAGTTAAAAATAGCTTTTGCCAGTGCGGCCAAAGCAGCGGATCG
AACGGCATCTCAGCTTTTACGCGATTTCATGCGAGATTTTGTCAGTCGACAATCGCAGCAAAAAGAGTATGAACAGTGGT
TGCAGGTGAAGGTCGATTTAAGCCGAAAAGCGCTCCAGGAAGGAAGAGTGGTTGATAACGAGGACGTTGAGGCTTATTTC
GCCGAGCGCAGGGCAAAATCAATGCGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3G8W1K6

Antitoxin

Source ID Structure
AlphaFold DB A0A3G8VZN0

References