Detailed information of TA system TA154564

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicB-HicA
• Location: 1711594..1712239
• Replicon: chromosome
• Accession: NZ_CP051639
• Organism: Avibacterium paragallinarum strain ADL-AP10

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: A0A0F5ESB4
• Locus tag: HHJ59_RS08005
• Protein ID: WP_017805948.1
• Coordinates: 1711594..1711776 (+)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: A0A0F5EU47
• Locus tag: HHJ59_RS08010
• Protein ID: WP_017805949.1
• Coordinates: 1711820..1712239 (+)
• Length: 140 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HHJ59_RS07980	1707077..1708042	-	966	WP_035685202.1	hypothetical protein	-
HHJ59_RS07985	1708020..1708352	-	333	WP_017805944.1	hypothetical protein	-
HHJ59_RS07990	1708460..1709302	-	843	WP_168939948.1	phage antirepressor N-terminal domain-containing protein	-
HHJ59_RS07995	1709628..1710779	-	1152	WP_168939949.1	type I restriction enzyme HsdR N-terminal domain-containing protein	-
HHJ59_RS08000	1710911..1711504	-	594	WP_035685204.1	hypothetical protein	-
HHJ59_RS08005	1711594..1711776	+	183	WP_017805948.1	type II toxin-antitoxin system HicA family toxin	Toxin
HHJ59_RS08010	1711820..1712239	+	420	WP_017805949.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
HHJ59_RS08015	1712277..1714535	-	2259	WP_017805950.1	tape measure protein	-
HHJ59_RS08020	1714532..1714684	-	153	WP_017805951.1	hypothetical protein	-
HHJ59_RS08025	1714720..1715205	-	486	WP_017805952.1	hypothetical protein	-
HHJ59_RS08030	1715205..1715633	-	429	WP_017805953.1	DUF3277 family protein	-
HHJ59_RS08035	1715685..1716758	-	1074	WP_017805954.1	DUF3383 family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1698445..1766222	67777

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (3-58)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (4-63)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 7001.21 Da
• Isoelectric Point: 10.4722

>T154564 WP_017805948.1 NZ_CP051639:1711594-1711776 [Avibacterium paragallinarum]
MKYSEFLRYLLEQGCKVENTKRGSHRKVMLNGHQTVFPYHGSQEIGTGLVHKIKKDLKLK

Nucleotide

• Length: 183 bp

>T154564 NZ_CP068147:4051020-4051478 [Yersinia enterocolitica]
ATGATACTCTACCGCATCGTGATGCGCCGCTATCTTGCCTCAACCTGGACCGGCTATGGTGCCGAAATCTATGGTGGCCG
CTGGAACCATAAGGGGCACGCCGCCATCTACTTAGCCAGCAGTGTATCACTGGCGATGTTGGAGACATTGGTACATATTC
AGGACAGCTCAACACTGAGTGAGTTCGAGTTATTCCAAATTGAAATCGAAGATAGCAACATTATGCTGCTTCAGCCGCAA
GATTGGCCCACGAACTGGCGTAGCGACCCCGCACCTGCGACCACAATGGATATCGGCACTGAATGGCTGGAATCAGAATC
ATCACTCGGATTACTGGTTCCATCCACTCTGGTGCCGACAGAAAACAATCTGCTGCTCAACCCTCAACACAAAAGTTTTC
AAGCCTGTTTAAGCAGTGTTCAACCACTCTCTTTTGCCTTTGACCCACGGCTGAAATAG

Antitoxin

Protein

• Length: 140 a.a.
• Molecular weight: 15815.31 Da
• Isoelectric Point: 4.7276

>AT154564 WP_017805949.1 NZ_CP051639:1711820-1712239 [Avibacterium paragallinarum]
MLRYPVELKADDNGTFLVTFPDIPEAASVGEDIESALLEAEEGLETALEFYFDDKRPIPLPSKPQEGQYTVPLSLLRSLK
VLLLNEMLAQGVRKAEMARRLDVHMPQIDRLLDFRYPSKIDFVEKAFKKLGREIHLAVS

Nucleotide

• Length: 420 bp

>AT154564 NZ_CP068147:4050518-4050964 [Yersinia enterocolitica]
ATGAGAGCATATCACCCCACTCCAGCGACTAAAACAAGGGCGCTATGGCGAGAGATTGGTTTGCCCGCCAGCCGCGGTAC
TGTATTGGTCGATAGCATCAAAATGGGTTTTTCTGTTGATGTCATTGACAGCATTCATCTATGGGCATCTATTCCAAAAG
CTGAAATCTTGCGTGCGACCGGTATTCCCAGCCGTAGCTTGACCCGCAGACGCACCCATGATGGCCGTTTCACTCCCGAA
GAGAGTGAGCGCATTGCGCGCTTCGTGCGGGTTATGGACGCCGCAGTTGATCTATTTGGCGGAGATAAAGGCAAAGCTAT
CACTTGGATGTCGACCCCGATTAAAGGCCTGGGCCACCGTAGTCCGGATTCCTTACTGGAAACTGAAACCGGTGCATTGG
AAGTCTGTGATTTGGTTGGACGCCTGGAGCACGGCGTATTTTCATAA

Structures

Toxin

• AlphaFold DB: A0A0F5ESB4

Antitoxin

• AlphaFold DB: A0A0F5EU47