Detailed information of TA system TA154554

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YafQ-RelB
• Location: 1315063..1315650
• Replicon: chromosome
• Accession: NZ_CP051638
• Organism: Avibacterium paragallinarum strain ADL-AP15

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: HHJ60_RS06170
• Protein ID: WP_103846679.1
• Coordinates: 1315063..1315326 (-)
• Length: 88 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A3G8W4K1
• Locus tag: HHJ60_RS06175
• Protein ID: WP_035686016.1
• Coordinates: 1315360..1315650 (-)
• Length: 97 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HHJ60_RS06145	1310095..1310709	-	615	WP_046097415.1	Holliday junction branch migration protein RuvA	-
HHJ60_RS06150	1310797..1311357	-	561	WP_035685784.1	crossover junction endodeoxyribonuclease RuvC	-
HHJ60_RS06155	1311433..1312173	-	741	WP_035685786.1	YebC/PmpR family DNA-binding transcriptional regulator	-
HHJ60_RS06160	1312627..1313070	-	444	WP_035685789.1	dihydroneopterin triphosphate diphosphatase	-
HHJ60_RS06165	1313196..1314974	-	1779	WP_035685792.1	aspartate--tRNA ligase	-
HHJ60_RS06170	1315063..1315326	-	264	WP_103846679.1	type II toxin-antitoxin system YafQ family toxin	Toxin
HHJ60_RS06175	1315360..1315650	-	291	WP_035686016.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
HHJ60_RS06180	1315842..1316567	+	726	WP_035685795.1	carboxy-S-adenosyl-L-methionine synthase CmoA	-
HHJ60_RS06185	1316688..1317641	-	954	WP_168939935.1	porin	-
HHJ60_RS06190	1317586..1317768	-	183	WP_168939936.1	hypothetical protein	-
HHJ60_RS06195	1317991..1319058	-	1068	WP_046097416.1	porin	-
HHJ60_RS06200	1319331..1320443	-	1113	Protein_1193	porin	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, YafQ-like toxin (2-86)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-71)

Sequences

Toxin

Protein

• Length: 88 a.a.
• Molecular weight: 10200.10 Da
• Isoelectric Point: 9.1425

>T154554 WP_103846679.1 NZ_CP051638:c1315326-1315063 [Avibacterium paragallinarum]
MAKEFKRDLVQLAKKAPHLFVHPRYLEVMHCLTNGLTLPAEYKNHPLKNNLKGYMDCHILNDLVLIYKIEQQCLKLVRLN
THSEVFA

Nucleotide

• Length: 264 bp

>T154554 NZ_CP068147:1022271-1022549 [Yersinia enterocolitica]
ATGATAAAAAGTTGGAAACACAAAGGACTGCAACGCTTCTTTGAAACAGGTTCTGCCGCGGGCATTAATCCCCAGCATGT
TAAGCGAATTCGAGACCGCTTGCGATTTATCGACCTGGCGGAAACGATTGAGGATGTCAATGTTGCCGGATACAAGCTCC
ATCCGTTACAAGGTGAAAGAGAAGGGATCTGGTCAGTAACAGTAAGCGGAAATTGGCGCATTACATTCGAGTTTACCGCT
GGAGATGCGTTTATTCTTAACTACGAGGACTACCACTAA

Antitoxin

Protein

• Length: 97 a.a.
• Molecular weight: 10716.23 Da
• Isoelectric Point: 4.7185

>AT154554 WP_035686016.1 NZ_CP051638:c1315650-1315360 [Avibacterium paragallinarum]
MTNNNAVVNFRLPQHLKTEAFEVIAQYGLTPSQVFNMFLTEIATTKAIPLSLNYLQPNAKTLAAMNEIESGTAERFSLDD
KTDLATLLQQIAEEKK

Nucleotide

• Length: 291 bp

>AT154554 NZ_CP068147:1022549-1022854 [Yersinia enterocolitica]
ATGAAAATGCATAATCCCCCACATCCAGGGGAAATGATTGAAGGAATCCTCGAAGATTTGGGTCTAGGGATAAGGGAGTT
TGCCAGGGCATTAAACGTGTCACCTTCAACGGTACAACGGCTGGTTGCCTGTAAGGCGGCAATTTCACCGGAAATGGCGG
TAAAACTGGCCGCGGTTCTGGGAAGTACCCCAGCAATGTGGCTCCGCCTCCAGGCCGCTTATGACCTGGGAAAAGCAGAA
GAGAATGTTGATGTATCCAATCTGACTAAACTGTACAAACCGGATCCAATATCGCTGCATAGTTGA

Structures

Antitoxin

• AlphaFold DB: A0A3G8W4K1