Detailed information of TA system TA154552

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-couple_hipB
• Location: 693441..695074
• Replicon: chromosome
• Accession: NZ_CP051638
• Organism: Avibacterium paragallinarum strain ADL-AP15

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: A0A3G8W245
• Locus tag: HHJ60_RS03345
• Protein ID: WP_035684858.1
• Coordinates: 693767..695074 (-)
• Length: 436 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: -
• Locus tag: HHJ60_RS03340
• Protein ID: WP_081637498.1
• Coordinates: 693441..693767 (-)
• Length: 109 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HHJ60_RS03320	688943..689674	+	732	WP_035684848.1	class I SAM-dependent methyltransferase	-
HHJ60_RS03325	689781..691550	+	1770	WP_035684851.1	30S ribosomal protein S12 methylthiotransferase accessory factor YcaO	-
HHJ60_RS03330	691685..692107	+	423	WP_035684853.1	DUF1043 family protein	-
HHJ60_RS03335	692270..693400	+	1131	WP_035684855.1	ribonucleotide-diphosphate reductase subunit beta	-
HHJ60_RS03340	693441..693767	-	327	WP_081637498.1	helix-turn-helix domain-containing protein	Antitoxin
HHJ60_RS03345	693767..695074	-	1308	WP_035684858.1	HipA domain-containing protein	Toxin
HHJ60_RS03350	695174..695422	-	249	WP_035684861.1	2Fe-2S ferredoxin-like protein	-
HHJ60_RS03355	696697..697509	-	813	WP_035684866.1	4-hydroxy-tetrahydrodipicolinate reductase	-
HHJ60_RS03360	697524..698159	-	636	WP_035684869.1	LysE family transporter	-
HHJ60_RS03365	698171..698671	-	501	WP_017806513.1	phosphatidylglycerophosphatase A	-
HHJ60_RS03370	698677..699711	-	1035	WP_035684872.1	thiamine-phosphate kinase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA-like, C-terminal (158-351)

Antitoxin

• Cro/C1-type helix-turn-helix domain (38-90)

Sequences

Toxin

Protein

• Length: 436 a.a.
• Molecular weight: 50363.28 Da
• Isoelectric Point: 5.6627

>T154552 WP_035684858.1 NZ_CP051638:c695074-693767 [Avibacterium paragallinarum]
MEKLTLQTYIDQEWRDMAELHFEKETYQLSNLVYFPDYITQYFGQEGSRAVSINYPVHIFIENRKTLWSCIGDIAPAGAS
RRYWIESLDIKHLPESEQNYRLLKYGAISPVGNLRIKEATPQKTEVRYFDIEKVKDRQSDFLEYANQSGAMVGGATGAGG
EAPKLLLKRHNGKVWIDNLQDGKDQDISYLVKYPRGRYSPIDCDILRAEFHYYQEVAELGFDTIDIHHMCLEEGERYPSL
WLPRFDITKKEGKYNRLALESVYSMLQKQGGTLEHEVTIRQLIKIISASNLEFDQQHFVLEWVKRDLLNIAFGNSDNHGR
NMAFLRDEQKIWLAPIYDFAPMRADPEGIIRSTTWNRKGSLPQEFAGEYRFDLIAESLSDLIEPSLLLTELQQLAIRLVD
LKSRLAQRGVPQAILDHPSIGFDYLPEKLKAWGLV

Nucleotide

• Length: 1308 bp

>T154552 NZ_CP068146:4185693-4186151 [Yersinia enterocolitica]
ATGATACTCTACCGCATCGTGATGCGCCGCTATCTTGCCTCAACCTGGACCGGCTATGGTGCCGAAATCTATGGTGGCCG
CTGGAACCATAAGGGGCACGCCGCCATCTACTTAGCCAGCAGTGTATCACTGGCGATGTTGGAGACATTGGTACATATTC
AGGACAGCTCAACACTGAGTGAGTTCGAGTTATTCCAAATTGAAATCGAAGATAGCAACATTATGCTGCTTCAGCCGCAA
GATTGGCCCACGAACTGGCGTAGCGACCCCGCACCTGCGACCACAATGGATATCGGCACTGAATGGCTGGAATCAGAATC
ATCACTCGGATTACTGGTTCCATCCACTCTGGTGCCGACAGAAAACAATCTGCTGCTCAACCCTCAACACAAAAGTTTTC
AAGCCTGTTTAAGCAGTGTTCAACCACTCTCTTTTGCCTTTGACCCACGGCTGAAATAG

Antitoxin

Protein

• Length: 109 a.a.
• Molecular weight: 12252.39 Da
• Isoelectric Point: 10.9810

>AT154552 WP_081637498.1 NZ_CP051638:c693767-693441 [Avibacterium paragallinarum]
MITRKNASKVGATISTTERNNVRNRIIKALLLGKMTQGQALRKLRIEMLGVNQQQYMKVVKVSRQTLSNIENDKGNYSVE
TINQVFKPFGFELGLVPISKELLTEIMQ

Nucleotide

• Length: 327 bp

>AT154552 NZ_CP068146:4185191-4185637 [Yersinia enterocolitica]
ATGAGAGCATATCACCCCACTCCAGCGACTAAAACAAGGGCGCTATGGCGAGAGATTGGTTTGCCCGCCAGCCGCGGTAC
TGTATTGGTCGATAGCATCAAAATGGGTTTTTCTGTTGATGTCATTGACAGCATTCATCTATGGGCATCTATTCCAAAAG
CTGAAATCTTGCGTGCGACCGGTATTCCCAGCCGTAGCTTGACCCGCAGACGCACCCATGATGGCCGTTTCACTCCCGAA
GAGAGTGAGCGCATTGCGCGCTTCGTGCGGGTTATGGACGCCGCAGTTGATCTATTTGGCGGAGATAAAGGCAAAGCTAT
CACTTGGATGTCGACCCCGATTAAAGGCCTGGGCCACCGTAGTCCGGATTCCTTACTGGAAACTGAAACCGGTGCATTGG
AAGTCTGTGATTTGGTTGGACGCCTGGAGCACGGCGTATTTTCATAA

Structures

Toxin

• AlphaFold DB: A0A3G8W245