Detailed information of TA system TA154550

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-DnaT
• Location: 327388..327928
• Replicon: chromosome
• Accession: NZ_CP051638
• Organism: Avibacterium paragallinarum strain ADL-AP15

Toxin (Protein)

• Gene name: relE
• Uniprot ID: A0A3G8VZS8
• Locus tag: HHJ60_RS01770
• Protein ID: WP_035688134.1
• Coordinates: 327638..327928 (+)
• Length: 97 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A3G8W1I3
• Locus tag: HHJ60_RS01765
• Protein ID: WP_035688131.1
• Coordinates: 327388..327648 (+)
• Length: 87 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HHJ60_RS01730	322709..322867	+	159	WP_168977192.1	hypothetical protein	-
HHJ60_RS01740	323514..324725	+	1212	WP_035688123.1	tyrosine-type recombinase/integrase	-
HHJ60_RS01745	324956..325105	-	150	WP_156127747.1	hypothetical protein	-
HHJ60_RS01750	325385..325591	+	207	WP_035688126.1	AlpA family phage regulatory protein	-
HHJ60_RS01755	325595..326272	+	678	WP_035688128.1	hypothetical protein	-
HHJ60_RS01760	326284..327249	+	966	WP_035688129.1	P2 family phage major capsid protein	-
HHJ60_RS01765	327388..327648	+	261	WP_035688131.1	stability protein StbD	Antitoxin
HHJ60_RS01770	327638..327928	+	291	WP_035688134.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
HHJ60_RS01775	327970..329070	+	1101	WP_051128101.1	hypothetical protein	-
HHJ60_RS01780	329234..329449	+	216	WP_035688136.1	helix-turn-helix domain-containing protein	-
HHJ60_RS01785	329460..329765	+	306	WP_035688139.1	hypothetical protein	-
HHJ60_RS01790	329869..330441	+	573	WP_051128102.1	ash family protein	-
HHJ60_RS01795	330434..330664	+	231	WP_035688141.1	hypothetical protein	-
HHJ60_RS01800	330657..330926	+	270	WP_035688144.1	hypothetical protein	-
HHJ60_RS01805	330931..331155	+	225	WP_035688166.1	hypothetical protein	-
HHJ60_RS01810	331155..331496	+	342	WP_035688146.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-82)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 97 a.a.
• Molecular weight: 11399.31 Da
• Isoelectric Point: 10.6318

>T154550 WP_035688134.1 NZ_CP051638:327638-327928 [Avibacterium paragallinarum]
MTYKLSFDKRALKEWHKLGDTLRQQFKAKLIERLENPHVLSDKLHGYQTLYKIKLRSAGYRLVYDVNDNEIRVIVLSVGK
REHLQAYKKALSRKAQ

Nucleotide

• Length: 291 bp

>T154550 NZ_CP068146:c3078722-3078519 [Yersinia enterocolitica]
ATGACAAAAACTGACTACCTGATGCGTTTAAGAAAATGTACGACTATTGATACATTGGAACGTGTAATTGAAAAAAATAA
GTACGAACTTTCTGACGATGAGCTGGAATTGTTTTACTCAGCAGCAGACCACCGCTTAGCTGAACTCACAATGAATAAAC
TTTATGATAAAATTCCACCTACTGTATGGCAACATGTGAAATAG

Antitoxin

Protein

• Length: 87 a.a.
• Molecular weight: 9550.98 Da
• Isoelectric Point: 4.1813

>AT154550 WP_035688131.1 NZ_CP051638:327388-327648 [Avibacterium paragallinarum]
MAIQQILTRHTASISDLKKNPMGIVSEGTEQEGAIAILNRNEPVFYCVNPCLFAVIQEILEDKELGELATQRLATLDPVE
VRLDDL

Nucleotide

• Length: 261 bp

>AT154550 NZ_CP068146:c3079137-3078769 [Yersinia enterocolitica]
ATGGATGAGTACTCACCTAAGCGGCATGACGTTGCCCAATTGAAGTTCCTGTGCGAGAGTTTGTATGATGAAGGCATTGC
TACCCTTGGTGATAGCCATCATGGCTGGGTAAATGATCCAACTTCAGCCGTAAACCTGCAACTCAATGATTTGATCGAGC
ATATAGCTTCATTTGTGATGAGTTTTAAAATAAAATACCCGGATGACGGCGACCTTTCAGAGTTAGTGGAAGAATATTTA
GACGACACATATACTCTGTTTAGTAGTTACGGAATCAATGATCCGGAATTGCAGCGCTGGCAAAAAACTAAAGAGCGTTT
ATTCAGACTTTTCTCAGGGGAATACATCTGTACCCTGATGAAAACTTAG

Structures

Toxin

• AlphaFold DB: A0A3G8VZS8

Antitoxin

• AlphaFold DB: A0A3G8W1I3