Detailed information of TA system TA154549

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): PumA-relB/COG3657-dnstrm_HI1420
• Location: 266146..266733
• Replicon: chromosome
• Accession: NZ_CP051638
• Organism: Avibacterium paragallinarum strain ADL-AP15

Toxin (Protein)

• Gene name: PumA
• Uniprot ID: -
• Locus tag: HHJ60_RS01350
• Protein ID: WP_136711940.1
• Coordinates: 266146..266442 (+)
• Length: 99 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: HHJ60_RS01355
• Protein ID: WP_017807324.1
• Coordinates: 266443..266733 (+)
• Length: 97 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HHJ60_RS11700	262098..262811	-	714	WP_174759910.1	hypothetical protein	-
HHJ60_RS01315	262741..262956	-	216	WP_168939988.1	hypothetical protein	-
HHJ60_RS01320	262953..263414	-	462	WP_168977191.1	hypothetical protein	-
HHJ60_RS01325	263404..263679	-	276	WP_035689243.1	hypothetical protein	-
HHJ60_RS01330	263701..264009	-	309	WP_046097548.1	hypothetical protein	-
HHJ60_RS01335	264103..264747	-	645	WP_051128137.1	hypothetical protein	-
HHJ60_RS01340	265421..265642	-	222	WP_017806446.1	hypothetical protein	-
HHJ60_RS01345	265657..265827	+	171	WP_017807323.1	DUF1508 domain-containing protein	-
HHJ60_RS01350	266146..266442	+	297	WP_136711940.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
HHJ60_RS01355	266443..266733	+	291	WP_017807324.1	putative addiction module antidote protein	Antitoxin
HHJ60_RS01360	266880..267653	-	774	WP_017807325.1	DUF1828 domain-containing protein	-
HHJ60_RS01365	267655..268140	-	486	WP_017807326.1	hypothetical protein	-
HHJ60_RS01370	268140..268793	-	654	WP_017807327.1	LexA family transcriptional regulator	-
HHJ60_RS01375	268931..269137	+	207	WP_017807328.1	helix-turn-helix transcriptional regulator	-
HHJ60_RS01380	269185..269625	+	441	Protein_267	hypothetical protein	-
HHJ60_RS01385	269643..270050	-	408	WP_168939907.1	hypothetical protein	-
HHJ60_RS01390	270160..270930	+	771	WP_046097539.1	phage regulatory protein/antirepressor Ant	-
HHJ60_RS01395	270927..271733	+	807	WP_035689420.1	helix-turn-helix domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	244567..292503	47936

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (12-89)

Antitoxin

• Cro/C1-type helix-turn-helix domain (44-89)

Sequences

Toxin

Protein

• Length: 99 a.a.
• Molecular weight: 11040.10 Da
• Isoelectric Point: 10.5997

>T154549 WP_136711940.1 NZ_CP051638:266146-266442 [Avibacterium paragallinarum]
MIQIKSTTLFKKWLDELKDLRARAKIQTRIKRLQLGNFGDVKPVGEGISELRITEGKGYRIYLKNQNGVVVILLCAGDKS
IQSKDIEKAKLLAKELGV

Nucleotide

• Length: 297 bp

>T154549 NZ_CP068146:c2430731-2430453 [Yersinia enterocolitica]
ATGATAAAAAGTTGGAAACACAAAGGACTGCAACGCTTCTTTGAAACAGGTTCTGCCGCGGGCATTAATCCCCAGCATGT
TAAGCGAATTCGAGACCGCTTGCGATTTATCGACCTGGCGGAAACGATTGAGGATGTCAATGTTGCCGGATACAAGCTCC
ATCCGTTACAAGGTGAAAGAGAAGGGATCTGGTCAGTAACAGTAAGCGGAAATTGGCGCATTACATTCGAGTTTACCGCT
GGAGATGCGTTTATTCTTAACTACGAGGACTACCACTAA

Antitoxin

Protein

• Length: 97 a.a.
• Molecular weight: 10812.39 Da
• Isoelectric Point: 4.8550

>AT154549 WP_017807324.1 NZ_CP051638:266443-266733 [Avibacterium paragallinarum]
MMELQDFDIAEHLRSEEEIQLYLNEVLQENDVDLILSALGDIAKARNMSQLAREVGVSREGLYKAFSGKGNPTFSTVLKV
MKALNLSFEVKRVTHA

Nucleotide

• Length: 291 bp

>AT154549 NZ_CP068146:c2430453-2430148 [Yersinia enterocolitica]
ATGAAAATGCATAATCCCCCACATCCAGGGGAAATGATTGAAGGAATCCTCGAAGATTTGGGTCTAGGGATAAGGGAGTT
TGCCAGGGCATTAAACGTGTCACCTTCAACGGTACAACGGCTGGTTGCCTGTAAGGCGGCAATTTCACCGGAAATGGCGG
TAAAACTGGCCGCGGTTCTGGGAAGTACCCCAGCAATGTGGCTCCGCCTCCAGGCCGCTTATGACCTGGGAAAAGCAGAA
GAGAATGTTGATGTATCCAATCTGACTAAACTGTACAAACCGGATCCAATATCGCTGCATAGTTGA