Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicB-HicA
Location 1711923..1712568 Replicon chromosome
Accession NZ_CP051637
Organism Avibacterium paragallinarum strain ADL-AP16

Toxin (Protein)


Gene name hicA Uniprot ID A0A0F5ESB4
Locus tag HHJ61_RS08000 Protein ID WP_017805948.1
Coordinates 1711923..1712105 (+) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A0F5EU47
Locus tag HHJ61_RS08005 Protein ID WP_017805949.1
Coordinates 1712149..1712568 (+) Length 140 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HHJ61_RS07975 1707406..1708371 - 966 WP_035685202.1 hypothetical protein -
HHJ61_RS07980 1708349..1708681 - 333 WP_017805944.1 hypothetical protein -
HHJ61_RS07985 1708789..1709631 - 843 WP_168939948.1 phage antirepressor N-terminal domain-containing protein -
HHJ61_RS07990 1709957..1711108 - 1152 WP_168939949.1 type I restriction enzyme HsdR N-terminal domain-containing protein -
HHJ61_RS07995 1711240..1711833 - 594 WP_035685204.1 hypothetical protein -
HHJ61_RS08000 1711923..1712105 + 183 WP_017805948.1 type II toxin-antitoxin system HicA family toxin Toxin
HHJ61_RS08005 1712149..1712568 + 420 WP_017805949.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
HHJ61_RS08010 1712606..1714864 - 2259 WP_017805950.1 tape measure protein -
HHJ61_RS08015 1714861..1715013 - 153 WP_017805951.1 hypothetical protein -
HHJ61_RS08020 1715049..1715534 - 486 WP_017805952.1 hypothetical protein -
HHJ61_RS08025 1715534..1715962 - 429 WP_017805953.1 DUF3277 family protein -
HHJ61_RS08030 1716014..1717087 - 1074 WP_017805954.1 DUF3383 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1698774..1766553 67779


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(3-58)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(4-63)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 7001.21 Da        Isoelectric Point: 10.4722

>T154548 WP_017805948.1 NZ_CP051637:1711923-1712105 [Avibacterium paragallinarum]
MKYSEFLRYLLEQGCKVENTKRGSHRKVMLNGHQTVFPYHGSQEIGTGLVHKIKKDLKLK

Download         Length: 183 bp

>T154548 NZ_CP068146:c2347877-2346549 [Yersinia enterocolitica]
ATGGCTCGTCGCATTCAACGGCTCAATATCTGGATGAATGGTCAGCACGTTGGCTATTGGGAAAAAAATCGAGGCGAAGA
ATCGCTGGTTTATGCCCAAGAATGGTTAGCAAACGAACAAGGCCGACCGCTATCATTATCATTGCCTTTCACTGCCAATA
ATCAGGTTTATAGAGGCAATATTGTCCGGGACTATTTTGATAATTTATTACCCGATAGCGATGATATCCGGCGACGTCTG
GCAACTAAATACCACGCTGACAGCATTAACCCTTTCGATCTATTGTTTGAATTAGGAAGAGATTGTGTCGGTGCAATACA
ATTGCTAACTGATGATGCTCCTCCCTCTGATCTATTCTCAATTCAACAACAACCACTAACAGAAAGCGATGTGGCTCGCA
TTCTACGAAACTCATTATCTGACAATGCATTTGTGCGCCCTGAACACGATGAGGATCTCAGATTGTCTATCGCAGGGGCA
CAAGAAAAAACAGCTCTTTTGTTTCACGACAACCGATGGTGCCTCCCATTGGGCAGCACTCCCACCACCCATATCTTCAA
ACTTCCGTTGGGCTTAGTCGGCAATATGCAAGCTGATATGAGGACCTCGGTTGAAAATGAATGGCTGTGTGCAAAAATTC
TGGCAAGTTATAACTTACCGGTCGCCAGTTGTGAAATTGGCCAGTTTGAAGACCAAAAAGCATTGATTGTTGAACGTTTT
GACCGACGTTTATCGCGTGACAAGAGTTGGATCGTCAGATTACCGCAAGAAGATATGTGCCAGGCCACTGGGACTTCTCC
CTTAAAAAAATATCAAATGGATGGTGGCCCCAGTATTACCACCATAATGGAGATTTTGAGTGGTTCGGATAATGCCAGTG
AAGACAGAAACGTCTTCTTTAAAGCACAGATTATTTTCTGGTTATTGGCCGCAACTGATGGACATGCAAAAAACTTTAGC
ATTGCTCATCTCCCCGGGAGTCGTTATCACCTCACGCCACTTTATGACGTGTTATCAACCCATCCGATTATCGGCTCGGG
TCGTAATCAGATTGCGGTTCAAAAATCCAAGTTAGCGATGGCGGTAAGAGGGAGTAAAAATTACTATTTGATTAACCAGA
TCCAACGCCGTCATTGGCGAAAACAGGCAGAATTTGTTGGACTAGGAGCGATTCAAGCTGACACTATTATCGATGAAATA
ATTGCCGCAACCCCACGGGTTATCACACAAGTACAAGCTCAACTTCCGGCTAATTTTCCTGCTGACTTAGCAGAGAAAAT
CCTTACTGGCCTTCATAAACAATGTGAAAAAATCTCGGCAATGCTTTGA

Antitoxin


Download         Length: 140 a.a.        Molecular weight: 15815.31 Da        Isoelectric Point: 4.7276

>AT154548 WP_017805949.1 NZ_CP051637:1712149-1712568 [Avibacterium paragallinarum]
MLRYPVELKADDNGTFLVTFPDIPEAASVGEDIESALLEAEEGLETALEFYFDDKRPIPLPSKPQEGQYTVPLSLLRSLK
VLLLNEMLAQGVRKAEMARRLDVHMPQIDRLLDFRYPSKIDFVEKAFKKLGREIHLAVS

Download         Length: 420 bp

>AT154548 NZ_CP068146:c2348178-2347879 [Yersinia enterocolitica]
ATGGACTATCCCATTAAAATTTTGAGTCAATTACGCCCGACGTTGATTGGTTTTCGAAAAAATAAAGGGCTGACTCAGGC
CAGCCTGGCACAACTGTTAGGAATCACCCAGCAGTCCTATGCAAAGCTTGAAGCTGATCCCACCTCGGCCAGTGTTGAAC
GGCTTTTTAAAGTATTACAACTTTTAGACGTAGAACTGATCCTTAGTGAGAAAAAAAACGCCAGCGCGCATCCCAATAAA
ACCCACCAGCCAGAACAAAGCCAGACGATAGATTTACCGTCAAAACAAGAGGATTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0F5ESB4

Antitoxin

Source ID Structure
AlphaFold DB A0A0F5EU47

References