Detailed information of TA system TA154546

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YafQ-RelB
• Location: 1314908..1315495
• Replicon: chromosome
• Accession: NZ_CP051637
• Organism: Avibacterium paragallinarum strain ADL-AP16

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: HHJ61_RS06155
• Protein ID: WP_103846679.1
• Coordinates: 1314908..1315171 (-)
• Length: 88 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A3G8W4K1
• Locus tag: HHJ61_RS06160
• Protein ID: WP_035686016.1
• Coordinates: 1315205..1315495 (-)
• Length: 97 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HHJ61_RS06130	1309940..1310554	-	615	WP_046097415.1	Holliday junction branch migration protein RuvA	-
HHJ61_RS06135	1310642..1311202	-	561	WP_035685784.1	crossover junction endodeoxyribonuclease RuvC	-
HHJ61_RS06140	1311278..1312018	-	741	WP_035685786.1	YebC/PmpR family DNA-binding transcriptional regulator	-
HHJ61_RS06145	1312472..1312915	-	444	WP_035685789.1	dihydroneopterin triphosphate diphosphatase	-
HHJ61_RS06150	1313041..1314819	-	1779	WP_035685792.1	aspartate--tRNA ligase	-
HHJ61_RS06155	1314908..1315171	-	264	WP_103846679.1	type II toxin-antitoxin system YafQ family toxin	Toxin
HHJ61_RS06160	1315205..1315495	-	291	WP_035686016.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
HHJ61_RS06165	1315687..1316412	+	726	WP_035685795.1	carboxy-S-adenosyl-L-methionine synthase CmoA	-
HHJ61_RS06170	1316533..1317486	-	954	WP_168939935.1	porin	-
HHJ61_RS06175	1317431..1317613	-	183	WP_168939936.1	hypothetical protein	-
HHJ61_RS06180	1317836..1318903	-	1068	WP_046097416.1	porin	-
HHJ61_RS06185	1319176..1320288	-	1113	Protein_1189	porin	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, YafQ-like toxin (2-86)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-71)

Sequences

Toxin

Protein

• Length: 88 a.a.
• Molecular weight: 10200.10 Da
• Isoelectric Point: 9.1425

>T154546 WP_103846679.1 NZ_CP051637:c1315171-1314908 [Avibacterium paragallinarum]
MAKEFKRDLVQLAKKAPHLFVHPRYLEVMHCLTNGLTLPAEYKNHPLKNNLKGYMDCHILNDLVLIYKIEQQCLKLVRLN
THSEVFA

Nucleotide

• Length: 264 bp

>T154546 NZ_CP068146:1977960-1978379 [Yersinia enterocolitica]
ATGATCAAAAAATTATATATGCTTGATACGAATATTTGTTCTTTTATTATGCGGGAACGACCAGCAGAATTAATTATAAA
ATTACAACAGTGTATTGAGCATCAGAATAAAATAGTTGTTTCAGCAATTACATACTCAGAAATGCGGTTTGGCGCTATAG
GTAAGAAAGCATCTCCAAAGCATAATTATTTAGTTGATGAATTTGTAAAAAGGTTAGATGCTATTTTACCGTGGGATACC
GCAGCTGTTGATGCCACGACTAATATTAAGGTTGAGCTGGCAAAGCAGGGGACACCAATTGGTGGAAATGATGCCGCAAT
AGCCGGGCACGCAGTTTCTGCTGGAGCAATATTAGTCACTAATAATATTAGAGAGTTTGAACGAGTTAAAAAACTACGAA
TTGAAGATTGGACTCAATAA

Antitoxin

Protein

• Length: 97 a.a.
• Molecular weight: 10716.23 Da
• Isoelectric Point: 4.7185

>AT154546 WP_035686016.1 NZ_CP051637:c1315495-1315205 [Avibacterium paragallinarum]
MTNNNAVVNFRLPQHLKTEAFEVIAQYGLTPSQVFNMFLTEIATTKAIPLSLNYLQPNAKTLAAMNEIESGTAERFSLDD
KTDLATLLQQIAEEKK

Nucleotide

• Length: 291 bp

>AT154546 NZ_CP068146:1977736-1977963 [Yersinia enterocolitica]
ATGAGAACGGTATCTATTTTCAAAAATGGGCAGAATCGAGCAATTCGTTTGCCAAAAGATATGGATTTTGATGGCGTGAC
CGAGCTGGAAATACTCAGAGACGGTGATAGTATTATTTTACGACCCATACGCCCGACATGGGTATCATTCATGGATGAAG
ATAAGGCAGATGATGATTTTCTTGCCGAAAGACAGGATGTTATCGAAGAAGGACGCTTCGAGTTATGA

Structures

Antitoxin

• AlphaFold DB: A0A3G8W4K1