Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-DnaT
Location 327384..327924 Replicon chromosome
Accession NZ_CP051637
Organism Avibacterium paragallinarum strain ADL-AP16

Toxin (Protein)


Gene name relE Uniprot ID A0A3G8VZS8
Locus tag HHJ61_RS01760 Protein ID WP_035688134.1
Coordinates 327634..327924 (+) Length 97 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A3G8W1I3
Locus tag HHJ61_RS01755 Protein ID WP_035688131.1
Coordinates 327384..327644 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HHJ61_RS01730 323510..324721 + 1212 WP_035688123.1 tyrosine-type recombinase/integrase -
HHJ61_RS01735 324952..325101 - 150 WP_156127747.1 hypothetical protein -
HHJ61_RS01740 325381..325587 + 207 WP_035688126.1 AlpA family phage regulatory protein -
HHJ61_RS01745 325591..326268 + 678 WP_035688128.1 hypothetical protein -
HHJ61_RS01750 326280..327245 + 966 WP_035688129.1 P2 family phage major capsid protein -
HHJ61_RS01755 327384..327644 + 261 WP_035688131.1 stability protein StbD Antitoxin
HHJ61_RS01760 327634..327924 + 291 WP_035688134.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HHJ61_RS01765 327966..329066 + 1101 WP_051128101.1 hypothetical protein -
HHJ61_RS01770 329230..329445 + 216 WP_035688136.1 helix-turn-helix domain-containing protein -
HHJ61_RS01775 329456..329761 + 306 WP_035688139.1 hypothetical protein -
HHJ61_RS01780 329865..330437 + 573 WP_051128102.1 ash family protein -
HHJ61_RS01785 330430..330660 + 231 WP_035688141.1 hypothetical protein -
HHJ61_RS01790 330653..330922 + 270 WP_035688144.1 hypothetical protein -
HHJ61_RS01795 330927..331151 + 225 WP_035688166.1 hypothetical protein -
HHJ61_RS01800 331151..331492 + 342 WP_035688146.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-82)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11399.31 Da        Isoelectric Point: 10.6318

>T154542 WP_035688134.1 NZ_CP051637:327634-327924 [Avibacterium paragallinarum]
MTYKLSFDKRALKEWHKLGDTLRQQFKAKLIERLENPHVLSDKLHGYQTLYKIKLRSAGYRLVYDVNDNEIRVIVLSVGK
REHLQAYKKALSRKAQ

Download         Length: 291 bp

>T154542 NZ_CP068146:c1255224-1254949 [Yersinia enterocolitica]
ATGGAAATTTACTGGACGCTTAAAGCTCAGGATGACCTGGAGCGTATCTACTGTTTTGCCCTTCAGTACAGCCGCCAGCA
CGGCGATGACGTTTTGGATCGCCTGATTACAGGCTGTGCTGGTCTTACAGCGTATCCGGCAATTGGCGTACAGCAGACTC
GGTATGAACCTCGGGAAGTCCGAAAAGTGTTATTTGATGATTATGAGGTTCACTACGAACTTCGTGACAATGACATCTAT
ATCGTGGATCTCTGGCATACCAAAGAAGAACGATGA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9550.98 Da        Isoelectric Point: 4.1813

>AT154542 WP_035688131.1 NZ_CP051637:327384-327644 [Avibacterium paragallinarum]
MAIQQILTRHTASISDLKKNPMGIVSEGTEQEGAIAILNRNEPVFYCVNPCLFAVIQEILEDKELGELATQRLATLDPVE
VRLDDL

Download         Length: 261 bp

>AT154542 NZ_CP068146:c1255476-1255228 [Yersinia enterocolitica]
ATGGGTTCGCTTACTAAACAAACTATCAGCGCACAGATACCTGTTGAGTTGGCTACTGCTGTTGAAAATCTGGCAATTGA
GTTAGATCGTTCTAAAAGTTGGATTATTAAGGAAGCGTTGACCAGTATGCTGGCCGAAAGAGAACGGCGTCACCAGAGCA
TCCAGGCCGGTCTCGCGGATGTGGATGCTGGTCGCGTGGTGAGCCACTCGGACATGGTAGATTTTGCTAATCGCTTAAAG
CAATCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3G8VZS8

Antitoxin

Source ID Structure
AlphaFold DB A0A3G8W1I3

References