Detailed information of TA system TA154541

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): PumA-relB/COG3657-dnstrm_HI1420
• Location: 266142..266729
• Replicon: chromosome
• Accession: NZ_CP051637
• Organism: Avibacterium paragallinarum strain ADL-AP16

Toxin (Protein)

• Gene name: PumA
• Uniprot ID: -
• Locus tag: HHJ61_RS01345
• Protein ID: WP_136711940.1
• Coordinates: 266142..266438 (+)
• Length: 99 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: HHJ61_RS01350
• Protein ID: WP_017807324.1
• Coordinates: 266439..266729 (+)
• Length: 97 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HHJ61_RS01305	261581..262522	-	942	WP_035689276.1	hypothetical protein	-
HHJ61_RS01315	262737..263411	-	675	WP_051128138.1	hypothetical protein	-
HHJ61_RS01320	263401..263676	-	276	WP_035689243.1	hypothetical protein	-
HHJ61_RS01325	263698..264006	-	309	WP_046097548.1	hypothetical protein	-
HHJ61_RS01330	264100..264744	-	645	WP_051128137.1	hypothetical protein	-
HHJ61_RS01335	265417..265638	-	222	WP_017806446.1	hypothetical protein	-
HHJ61_RS01340	265653..265823	+	171	WP_017807323.1	DUF1508 domain-containing protein	-
HHJ61_RS01345	266142..266438	+	297	WP_136711940.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
HHJ61_RS01350	266439..266729	+	291	WP_017807324.1	putative addiction module antidote protein	Antitoxin
HHJ61_RS01355	266876..267649	-	774	WP_017807325.1	DUF1828 domain-containing protein	-
HHJ61_RS01360	267651..268136	-	486	WP_017807326.1	hypothetical protein	-
HHJ61_RS01365	268136..268789	-	654	WP_017807327.1	LexA family transcriptional regulator	-
HHJ61_RS01370	268927..269133	+	207	WP_017807328.1	helix-turn-helix transcriptional regulator	-
HHJ61_RS01375	269181..269621	+	441	Protein_265	hypothetical protein	-
HHJ61_RS01380	269639..270046	-	408	WP_168939907.1	hypothetical protein	-
HHJ61_RS01385	270156..270926	+	771	WP_046097539.1	phage regulatory protein/antirepressor Ant	-
HHJ61_RS01390	270923..271729	+	807	WP_035689420.1	helix-turn-helix domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	244556..292499	47943

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (12-89)

Antitoxin

• Cro/C1-type helix-turn-helix domain (44-89)

Sequences

Toxin

Protein

• Length: 99 a.a.
• Molecular weight: 11040.10 Da
• Isoelectric Point: 10.5997

>T154541 WP_136711940.1 NZ_CP051637:266142-266438 [Avibacterium paragallinarum]
MIQIKSTTLFKKWLDELKDLRARAKIQTRIKRLQLGNFGDVKPVGEGISELRITEGKGYRIYLKNQNGVVVILLCAGDKS
IQSKDIEKAKLLAKELGV

Nucleotide

• Length: 297 bp

>T154541 NZ_CP068146:c946571-946146 [Yersinia enterocolitica]
GTGGCCCAGTGGCGATGTGACCTGCGGATATCCTGGCACACTCAACTCTTCTCTCTATTAGCTCATGGCGTCCTGGTCAC
ATTAACGCTGGTTGCGCCTTGGCCTCAGGGCTATACCGCGCTGTGGTTGGTGCTACTGACGTTAGTGGTGTTTGAGTGTA
TCCGCAGCCAGAAAAATATTACGTCTTGCCAAGGTGAGATCAGGCTGAAACCCGGCAATATAGTGCTATGGAAACGGCAT
GAGTGGGTCGTCATTAAGCAGCCGTGGATCACCCGTTATGGCGTATTATTGAGTTTACAACAGACAAGCAGTCGCTCAAC
CCGTAAGCGTTTATGGCTAGCGGCTGATAGCATGTCTGAAGAGGAATGGCGGCAATTGTGTCTCCTGCTGCGCCATTCAT
TTGGCTCCGATGAAGGTATTAATTAA

Antitoxin

Protein

• Length: 97 a.a.
• Molecular weight: 10812.39 Da
• Isoelectric Point: 4.8550

>AT154541 WP_017807324.1 NZ_CP051637:266439-266729 [Avibacterium paragallinarum]
MMELQDFDIAEHLRSEEEIQLYLNEVLQENDVDLILSALGDIAKARNMSQLAREVGVSREGLYKAFSGKGNPTFSTVLKV
MKALNLSFEVKRVTHA

Nucleotide

• Length: 291 bp

>AT154541 NZ_CP068146:c946818-946552 [Yersinia enterocolitica]
ATGGAAATCGATAATAAAGCCCGTATTCACTGGGCGTGCCGTCGGGGTATGCGTGAACTGGATATCTCTATCATGCCGTT
TTTTGAACATGAATATGATGGCTTGAGCGATAACGAGAAACAGGTTTTTATCCGTTTGCTTGAGTGTGATGATCCAGATT
TATTTAACTGGTTGATGAATCACGGGGAACCGCAGGATAGTGAGCTGCGTCAAATGGTCAAACTGATTCAAACACGAAAT
AAAGCCCGTGGCCCAGTGGCGATGTGA