Detailed information of TA system TA154538

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YafQ-RelB
• Location: 1315095..1315682
• Replicon: chromosome
• Accession: NZ_CP051636
• Organism: Avibacterium paragallinarum strain ADL-AP17

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: HHJ62_RS06150
• Protein ID: WP_103846679.1
• Coordinates: 1315095..1315358 (-)
• Length: 88 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A3G8W4K1
• Locus tag: HHJ62_RS06155
• Protein ID: WP_035686016.1
• Coordinates: 1315392..1315682 (-)
• Length: 97 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HHJ62_RS06125	1310127..1310741	-	615	WP_046097415.1	Holliday junction branch migration protein RuvA	-
HHJ62_RS06130	1310829..1311389	-	561	WP_035685784.1	crossover junction endodeoxyribonuclease RuvC	-
HHJ62_RS06135	1311465..1312205	-	741	WP_035685786.1	YebC/PmpR family DNA-binding transcriptional regulator	-
HHJ62_RS06140	1312659..1313102	-	444	WP_035685789.1	dihydroneopterin triphosphate diphosphatase	-
HHJ62_RS06145	1313228..1315006	-	1779	WP_035685792.1	aspartate--tRNA ligase	-
HHJ62_RS06150	1315095..1315358	-	264	WP_103846679.1	type II toxin-antitoxin system YafQ family toxin	Toxin
HHJ62_RS06155	1315392..1315682	-	291	WP_035686016.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
HHJ62_RS06160	1315874..1316599	+	726	WP_035685795.1	carboxy-S-adenosyl-L-methionine synthase CmoA	-
HHJ62_RS06165	1316720..1317673	-	954	WP_168939935.1	porin	-
HHJ62_RS06170	1317618..1317800	-	183	WP_168939936.1	hypothetical protein	-
HHJ62_RS06175	1318023..1319090	-	1068	WP_046097416.1	porin	-
HHJ62_RS06180	1319363..1320475	-	1113	Protein_1188	porin	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, YafQ-like toxin (2-86)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-71)

Sequences

Toxin

Protein

• Length: 88 a.a.
• Molecular weight: 10200.10 Da
• Isoelectric Point: 9.1425

>T154538 WP_103846679.1 NZ_CP051636:c1315358-1315095 [Avibacterium paragallinarum]
MAKEFKRDLVQLAKKAPHLFVHPRYLEVMHCLTNGLTLPAEYKNHPLKNNLKGYMDCHILNDLVLIYKIEQQCLKLVRLN
THSEVFA

Nucleotide

• Length: 264 bp

>T154538 NZ_CP068145:2255071-2255415 [Morganella morganii]
GTGCGGACAGTATTATTAACGGATTATTTTAATGAGTGGTTATCAGGACAAGATACCCGGATGCAAGAAAAAGTACTCGC
ATCTCTCGGTAATCTTGAAATTTATGGTCCTGTTCTGACAAGACCTTATGTTGATACAGTTAAAAATTCTCAGTATCCGA
ATATGAAGGAATTGAGAATCTGGCATGCAGGTCGTGCGATACGTGCATTTTTTGCCTTTGATTCTGAAAGGCAGGCCATT
GTTTTATGTGCCGGGGATAAAGGGAAAAATAAACGATTTTATCAGACGATGATTCGTATTGCGGATGAACAATTTTCCTC
ATATCTTGCAGCAGCGAAGGAATAA

Antitoxin

Protein

• Length: 97 a.a.
• Molecular weight: 10716.23 Da
• Isoelectric Point: 4.7185

>AT154538 WP_035686016.1 NZ_CP051636:c1315682-1315392 [Avibacterium paragallinarum]
MTNNNAVVNFRLPQHLKTEAFEVIAQYGLTPSQVFNMFLTEIATTKAIPLSLNYLQPNAKTLAAMNEIESGTAERFSLDD
KTDLATLLQQIAEEKK

Nucleotide

• Length: 291 bp

>AT154538 NZ_CP068145:2255420-2255719 [Morganella morganii]
ATGAAAACATTACAGGAAGTGATAGCCGCTCAACCACCGGAGAGCCGTGAGCGGATAAAACGACTGACTGATGAGTTGGT
TCTTGAAACCGGGCTGCAACTTCTCAGAGAAGAACTTCATATCTCTCAGAAAATGCTGGCAACTAATCTTGGTATATCAC
AACCGGCTGTTACTCAGATTGAGCAGCGCGGTAATGATATCAAACTGGCAACACTGAAACGCTATATTGAGGCAATGGGC
GGAACACTCCGTCTGACGATCGAACTGCCGACCGGTGATAACCGGGTTTTTCGCGTCTGA

Structures

Antitoxin

• AlphaFold DB: A0A3G8W4K1