Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 934621..935207 Replicon chromosome
Accession NZ_CP051636
Organism Avibacterium paragallinarum strain ADL-AP17

Toxin (Protein)


Gene name hicA Uniprot ID A0A3G8W1K6
Locus tag HHJ62_RS04425 Protein ID WP_035687070.1
Coordinates 934621..934869 (+) Length 83 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A3G8VZN0
Locus tag HHJ62_RS04430 Protein ID WP_035687072.1
Coordinates 934866..935207 (+) Length 114 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HHJ62_RS04410 930653..931852 + 1200 WP_035688521.1 tyrosine--tRNA ligase -
HHJ62_RS04415 932162..933091 + 930 WP_035688523.1 aminoimidazole riboside kinase -
HHJ62_RS04420 933110..934561 + 1452 WP_046097372.1 glycoside hydrolase family 32 protein -
HHJ62_RS04425 934621..934869 + 249 WP_035687070.1 type II toxin-antitoxin system HicA family toxin Toxin
HHJ62_RS04430 934866..935207 + 342 WP_035687072.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
HHJ62_RS04435 935302..935778 + 477 WP_035687075.1 tRNA (adenosine(37)-N6)-threonylcarbamoyltransferase complex ATPase subunit type 1 TsaE -
HHJ62_RS04440 935791..937038 + 1248 WP_035687078.1 N-acetylmuramoyl-L-alanine amidase -
HHJ62_RS04445 937047..939020 + 1974 WP_035687081.1 DNA mismatch repair endonuclease MutL -
HHJ62_RS04450 939029..939955 + 927 WP_035687084.1 tRNA (adenosine(37)-N6)-dimethylallyltransferase MiaA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(20-81)

Antitoxin

Uncharacterised protein family HicB

(54-102)


Sequences

Toxin        


Download         Length: 83 a.a.        Molecular weight: 9219.85 Da        Isoelectric Point: 10.2543

>T154537 WP_035687070.1 NZ_CP051636:934621-934869 [Avibacterium paragallinarum]
MGKSEKLLEKLANAKNTFIWTDLLTLLARLGYEKREMAGSRVRFYNAELDHLILLHKPHPENYIKGGALKSVKEGLKGAG
LL

Download         Length: 249 bp

>T154537 NZ_CP068145:c1443816-1443613 [Morganella morganii]
ATGACTAAACTGGACTATCTCATGCGCTTACGTAAGTGCACTTCTATTGAAACACTGGAACGTGTCATTGAGAAGAACAA
ATATGAACTGACTGATGATGAGCTGGAGGTTTTTTATTCAGCAGCCGATCATCGTCTGGCCGAATTAACCATGAATAAAC
TGTATGACAAAATCCCGGCATCTGTCTGGAAATTTGTCCGTTAA

Antitoxin


Download         Length: 114 a.a.        Molecular weight: 12710.50 Da        Isoelectric Point: 4.5942

>AT154537 WP_035687072.1 NZ_CP051636:934866-935207 [Avibacterium paragallinarum]
MTLLKYKGYVGTIEADLENNVLFGKLAYIRDVITYEAETLPQLEKEFQTSVDLYLQDCQELGRTPDKPFKGVFNVRISEE
LHRNAVLAAGDLSLNAFVAEAIKEKVERAGITN

Download         Length: 342 bp

>AT154537 NZ_CP068145:c1444239-1443880 [Morganella morganii]
ATGGACGAGTATTCTCCACGAAATTACGATATTGCGGTACTGAAGTATCTGTGTGATGAACTTTGCCGTGAAGGCACACA
AACCCTCATCAGAAGCAATAATTATTGGGTTAATGATTTAGCCTCAGATTCAAACTTAAAACTTAACGAATTATTAGGTT
ACATTGCTGACGTGGCCTGGAGTTTTAAGATAAAACATACACAAAATAAGGATCTCATCTCATTTGTCGATGAATACATC
GATGAAACTTACGCGCTGTTTGGTCAGATGGAAGTTTCGTTTAATGACGTTGAGGAATGGAAGAAGATGGCATCACTGGT
AAGCAGCATGCTGACCAGCGAGGGGCATCTCGTCCACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3G8W1K6

Antitoxin

Source ID Structure
AlphaFold DB A0A3G8VZN0

References