Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumA-relB/COG3657-dnstrm_HI1420
Location 266061..266648 Replicon chromosome
Accession NZ_CP051636
Organism Avibacterium paragallinarum strain ADL-AP17

Toxin (Protein)


Gene name PumA Uniprot ID -
Locus tag HHJ62_RS01345 Protein ID WP_136711940.1
Coordinates 266061..266357 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag HHJ62_RS01350 Protein ID WP_017807324.1
Coordinates 266358..266648 (+) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HHJ62_RS01305 261608..262549 - 942 WP_035689276.1 hypothetical protein -
HHJ62_RS01315 262764..263438 - 675 WP_051128138.1 hypothetical protein -
HHJ62_RS01320 263428..263703 - 276 WP_035689243.1 hypothetical protein -
HHJ62_RS01325 263725..264033 - 309 WP_046097548.1 hypothetical protein -
HHJ62_RS01330 264127..264663 - 537 WP_168939906.1 hypothetical protein -
HHJ62_RS01335 265336..265557 - 222 WP_017806446.1 hypothetical protein -
HHJ62_RS01340 265572..265742 + 171 WP_017807323.1 DUF1508 domain-containing protein -
HHJ62_RS01345 266061..266357 + 297 WP_136711940.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HHJ62_RS01350 266358..266648 + 291 WP_017807324.1 putative addiction module antidote protein Antitoxin
HHJ62_RS01355 266795..267568 - 774 WP_017807325.1 DUF1828 domain-containing protein -
HHJ62_RS01360 267570..268055 - 486 WP_017807326.1 hypothetical protein -
HHJ62_RS01365 268055..268708 - 654 WP_017807327.1 LexA family transcriptional regulator -
HHJ62_RS01370 268846..269052 + 207 WP_017807328.1 helix-turn-helix transcriptional regulator -
HHJ62_RS01375 269100..269540 + 441 Protein_265 hypothetical protein -
HHJ62_RS01380 269558..269965 - 408 WP_168939907.1 hypothetical protein -
HHJ62_RS01385 270075..270845 + 771 WP_046097539.1 phage regulatory protein/antirepressor Ant -
HHJ62_RS01390 270842..271648 + 807 WP_035689420.1 helix-turn-helix domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 244583..292418 47835


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-89)

Antitoxin

Cro/C1-type helix-turn-helix domain

(44-89)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11040.10 Da        Isoelectric Point: 10.5997

>T154533 WP_136711940.1 NZ_CP051636:266061-266357 [Avibacterium paragallinarum]
MIQIKSTTLFKKWLDELKDLRARAKIQTRIKRLQLGNFGDVKPVGEGISELRITEGKGYRIYLKNQNGVVVILLCAGDKS
IQSKDIEKAKLLAKELGV

Download         Length: 297 bp

>T154533 NZ_CP068143:c933344-933249 [Staphylococcus aureus]
GTGATGCTTATTTTCGTTCACATCATAGCACCAGTCATCAGTGGCTGTGCCATTGCGTTTTTTTCTTATTGGCTAAGTAG
ACGCAATACAAAATAG

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10812.39 Da        Isoelectric Point: 4.8550

>AT154533 WP_017807324.1 NZ_CP051636:266358-266648 [Avibacterium paragallinarum]
MMELQDFDIAEHLRSEEEIQLYLNEVLQENDVDLILSALGDIAKARNMSQLAREVGVSREGLYKAFSGKGNPTFSTVLKV
MKALNLSFEVKRVTHA

Download         Length: 291 bp

>AT154533 NZ_CP068143:933162-933221 [Staphylococcus aureus]
ACAACGAAAATAAGTATTTACTTATACACCAATCCCCTCACTATTTGCGGTAGTGAGGGG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References