Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 2532749..2533383 Replicon chromosome
Accession NZ_CP051635
Organism Treponema denticola strain OMZ 905

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag E4N86_RS11725 Protein ID WP_253699420.1
Coordinates 2532749..2533153 (-) Length 135 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag E4N86_RS11730 Protein ID WP_253682979.1
Coordinates 2533153..2533383 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E4N86_RS11705 (E4N86_11720) 2529215..2530330 + 1116 WP_253717134.1 diguanylate cyclase DgcA -
E4N86_RS11710 (E4N86_11725) 2530352..2530981 + 630 WP_253717132.1 rhomboid family intramembrane serine protease -
E4N86_RS11715 (E4N86_11730) 2531002..2531682 + 681 WP_253699418.1 hypothetical protein -
E4N86_RS11720 (E4N86_11735) 2531686..2532699 + 1014 WP_253717130.1 tRNA-dihydrouridine synthase family protein -
E4N86_RS11725 (E4N86_11740) 2532749..2533153 - 405 WP_253699420.1 type II toxin-antitoxin system VapC family toxin Toxin
E4N86_RS11730 (E4N86_11745) 2533153..2533383 - 231 WP_253682979.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
E4N86_RS11735 (E4N86_11750) 2533541..2535106 - 1566 WP_253717129.1 LTA synthase family protein -
E4N86_RS11740 (E4N86_11755) 2535128..2536327 - 1200 WP_253699422.1 coenzyme F420-0:L-glutamate ligase -
E4N86_RS11745 (E4N86_11760) 2536455..2537789 + 1335 WP_253717128.1 DUF1015 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-124)

Antitoxin

SpoVT-AbrB domain

(7-46)


Sequences

Toxin        


Download         Length: 135 a.a.        Molecular weight: 15523.89 Da        Isoelectric Point: 6.9280

>T154532 WP_253699420.1 NZ_CP051635:c2533153-2532749 [Treponema denticola]
MYLLDTNICIFLIKNKNPYLKKKIFNCKKEELFLSSITIAELEYGVSKSQFREKNRHALLDFCSDFTNIIDFTTEDTETY
GMIRAYLENKGIPIGPFDTQIAAQALARNLTVVTNNIREFSRIPGLKVDDWTKE

Download         Length: 405 bp

>T154532 NZ_CP068143:875655-875807 [Staphylococcus aureus]
ATGTCTAAAGACAAAGATCCAAAATTAAATTATCATGAAGAAGAAAACAGTATGGTAACGGATTTTGAAGATTTAAAAGA
ATTAGGTAAAGAAATGGAACAAATCTCTGATCAAAATGATCAAGAAAAAAATTCTGAAGAAGACAGTCAGTAA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8755.95 Da        Isoelectric Point: 4.7660

>AT154532 WP_253682979.1 NZ_CP051635:c2533383-2533153 [Treponema denticola]
MICTKVFTSGNSQAVRIPKEFHIDFSELLIKKIGSSIILTPKESNWENLERSLSEFSDDFMTEGRSQPAMQEREVF

Download         Length: 231 bp

>AT154532 NZ_CP068143:875031-875630 [Staphylococcus aureus]
ATGGCAATGAACTTTAAAGTCTTTGACAATAGTCAACTTGTAGCAGAATATGCTGCTGATATTATTAGAAAGCAATTTAA
CAATAATCCTACTACAATTGCAGGTTTTCATTTAGATACAGATCAAGCGCCAGTTCTAGATGAATTAAAGAAAAATGTTG
AAAAACATGCTGTTGATTTTAGCCAAATAAATATTTTAGATTATGACGATAAAAAATCATATTTCGAAGCGTTAGGTGTA
CCAGCAGGTCAAGTTTATCCAATTGCTTATGAAAAAGATGCAATCGAATTAATCGCTGATAAGATTAAAACTAAAGAAAA
TAAAGGGAAATTAACATTACAAGTTGTTTCTATCGATGAGCAAGGTAAGTTAAATGTTAGTATTCGTCAAGGACTAATGG
AAGCAAGAGAAATTTTCTTAGTAGTGACAGGTGCTAATAAACGAGATGTAGTTGAAAAATTATATCAAGAAAATGGTAAA
ACAAGCTTCGAACCAGCCGATTTAAAAGCACATAGAATGGTAAATGTTATTCTTGATAAAGAAGCGGCTGCAGGTTTACC
TGAAGATGTTAAAGCTTACTTTACGTCACGCTTTGCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References