Detailed information of TA system TA154530

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YafQ-DinJ
• Location: 2132025..2132575
• Replicon: chromosome
• Accession: NZ_CP051635
• Organism: Treponema denticola strain OMZ 905

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: E4N86_RS09825
• Protein ID: WP_253717543.1
• Coordinates: 2132025..2132306 (-)
• Length: 94 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: Q73QD7
• Locus tag: E4N86_RS09830
• Protein ID: WP_002665927.1
• Coordinates: 2132303..2132575 (-)
• Length: 91 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
E4N86_RS09795 (E4N86_09815)	2127053..2127433	-	381	WP_253717549.1	hypothetical protein	-
E4N86_RS09800 (E4N86_09820)	2127550..2128677	-	1128	WP_253717547.1	hypothetical protein	-
E4N86_RS09805 (E4N86_09825)	2128854..2129918	-	1065	WP_253717546.1	ankyrin repeat domain-containing protein	-
E4N86_RS09810 (E4N86_09830)	2130011..2130418	-	408	WP_253717545.1	hypothetical protein	-
E4N86_RS09815 (E4N86_09835)	2130438..2131289	-	852	WP_253717544.1	DUF2262 domain-containing protein	-
E4N86_RS09820 (E4N86_09840)	2131327..2131950	-	624	WP_253699105.1	hypothetical protein	-
E4N86_RS09825 (E4N86_09845)	2132025..2132306	-	282	WP_253717543.1	type II toxin-antitoxin system YafQ family toxin	Toxin
E4N86_RS09830 (E4N86_09850)	2132303..2132575	-	273	WP_002665927.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
E4N86_RS09835 (E4N86_09855)	2132641..2132850	-	210	WP_002687090.1	hypothetical protein	-
E4N86_RS09840 (E4N86_09860)	2132901..2133617	-	717	WP_253682847.1	hypothetical protein	-
E4N86_RS09845 (E4N86_09865)	2133662..2134231	-	570	WP_253717542.1	hypothetical protein	-
E4N86_RS09850 (E4N86_09870)	2134287..2134958	-	672	WP_253717541.1	hypothetical protein	-
E4N86_RS09855 (E4N86_09875)	2134960..2135109	-	150	WP_253688683.1	hypothetical protein	-
E4N86_RS09860 (E4N86_09880)	2135161..2135319	-	159	WP_080648458.1	hypothetical protein	-
E4N86_RS09865 (E4N86_09885)	2135396..2136202	-	807	WP_010693405.1	DUF4261 domain-containing protein	-
E4N86_RS09870 (E4N86_09890)	2136310..2136633	-	324	WP_002685254.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, YafQ-like toxin (3-91)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-89)

Sequences

Toxin

Protein

• Length: 94 a.a.
• Molecular weight: 11099.96 Da
• Isoelectric Point: 9.8023

>T154530 WP_253717543.1 NZ_CP051635:c2132306-2132025 [Treponema denticola]
MKYEIKFTNQFKKDIKLAKKQNKNLDKLLKVIDLLSNGEKLEAKYRDHDLSGNYKGTRECHVEPDWLLVYEIRNDVLVLM
LYRLGSHSELFKK

Nucleotide

• Length: 282 bp

>T154530 NZ_CP068143:748159-748410 [Staphylococcus aureus]
ATGAATAACCGCGAACAAATTGAACAATCAATTATCAGTGCTAGTGCCTATAACGGTAATGACACAGAGGGATTACTAAA
AGAGGTTGAAGACGTGTATAAGAAAGCGCAAGCGTTTGATGAAATACTTGATGGAATGACAAATGCTATTCAACATTCAG
TTAAAGAAGGTGTTGAACTTGATGAAGCAGTAGGGATTATGGCAGGTCAAGTTGTCTATAAATATGAGGAGGAACAGGAA
AATGAGTATTAG

Antitoxin

Protein

• Length: 91 a.a.
• Molecular weight: 10205.78 Da
• Isoelectric Point: 5.1486

>AT154530 WP_002665927.1 NZ_CP051635:c2132575-2132303 [Treponema denticola]
MATTNLNIRTDKEMKERAEAIFFELGLNMTTAINIFLRTTIRENGIPFALKLDIPNAITASAIEEGRKIAYDDTVKKYSN
IDDLRKALEI

Nucleotide

• Length: 273 bp

>AT154530 NZ_CP068143:748400-748573 [Staphylococcus aureus]
ATGAGTATTAGTGTAGGAGATAAAGTATATAACCATGAAACAAACGAAAGTCTAGAGATTGTGCAATTGGTCGGAGATAT
TAGAGATACACATTATAAACTGTCCGATGATTCAGTTATTAGCATTATAGATTTTATTACTAAACCAATTTATCTAATTA
AGGGGGACGAGTGA

Structures

Antitoxin

• AlphaFold DB: Q73QD7