Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicA-relB/HicA-dnstrm_HI1420
Location 1630319..1630916 Replicon chromosome
Accession NZ_CP051635
Organism Treponema denticola strain OMZ 905

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag E4N86_RS07430 Protein ID WP_253718087.1
Coordinates 1630719..1630916 (+) Length 66 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag E4N86_RS07425 Protein ID WP_253718089.1
Coordinates 1630319..1630633 (+) Length 105 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E4N86_RS07405 (E4N86_07430) 1626281..1626994 - 714 WP_253718093.1 tRNA threonylcarbamoyladenosine dehydratase -
E4N86_RS07410 (E4N86_07435) 1627014..1628072 - 1059 WP_253718092.1 phospho-N-acetylmuramoyl-pentapeptide- transferase -
E4N86_RS07415 (E4N86_07440) 1628149..1628895 + 747 WP_253718091.1 DUF368 domain-containing protein -
E4N86_RS07420 (E4N86_07445) 1629041..1630303 + 1263 WP_253718090.1 uracil permease -
E4N86_RS07425 (E4N86_07450) 1630319..1630633 + 315 WP_253718089.1 putative addiction module antidote protein Antitoxin
E4N86_RS07430 (E4N86_07455) 1630719..1630916 + 198 WP_253718087.1 type II toxin-antitoxin system HicA family toxin Toxin
E4N86_RS07435 (E4N86_07460) 1630926..1631342 + 417 WP_253718086.1 type II toxin-antitoxin system HicB family antitoxin -
E4N86_RS07440 (E4N86_07465) 1631364..1632014 + 651 WP_253718085.1 C39 family peptidase -
E4N86_RS07445 (E4N86_07470) 1632076..1633257 - 1182 WP_253718084.1 YibE/F family protein -
E4N86_RS07450 (E4N86_07475) 1633372..1634973 - 1602 WP_253718083.1 5'-nucleotidase C-terminal domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(6-62)

Antitoxin

Cro/C1-type helix-turn-helix domain

(51-92)


Sequences

Toxin        


Download         Length: 66 a.a.        Molecular weight: 7475.73 Da        Isoelectric Point: 10.6290

>T154528 WP_253718087.1 NZ_CP051635:1630719-1630916 [Treponema denticola]
MKSYTSREVIKILQNDGWYEVAVVGSHHQFKHSIKKGRVTVKHPDKDIPIATLKTIEKQSGIKFK

Download         Length: 198 bp

>T154528 NZ_CP068143:656613-656822 [Staphylococcus aureus]
ATGATACATCAAAATACGATTTACACAGCGGGAATTGAAACAGAAGAACAAGTAAGTCAATTGACAGAACGCATTTCAAA
TATGATAGGTGTTCATCAAGTGAATATTAATATAATAGATGGTCAAGTAACTGTATCGTATGAGACACCAGCAAATTTGA
ATAGTATTGAAAAAGAAATCTATGATGAAGGATACAAAATTGTATTTTAG

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 11721.62 Da        Isoelectric Point: 8.4209

>AT154528 WP_253718089.1 NZ_CP051635:1630319-1630633 [Treponema denticola]
MKISKWDAADYLRTRKDIAIYLDEILKIAREDNTPELFIEALGDVTRAQGMADLAKTIDVSRESLYKSLSKKGNPSFSTI
FKVLEFLNLEISIAAPKTLKQVSI

Download         Length: 315 bp

>AT154528 NZ_CP068143:656308-656601 [Staphylococcus aureus]
ATGACTGAACAAGATAATGCACATCATTCTGAACAAATAAAAACGAATCTTAAATCACGTTTAAATCGAATTGAAGGACA
AGTGAGAGCGATTAATCGCATGATTGAAGAAGATGTCTATTGTGATGATGTCCTTACGCAAATAAGAGCGACACGTTCGG
CGTTAAACAGTGTTGCGATAAAGTTATTAGAACAACATATGAAAAGTTGTATTATGAATAAAGTTAATCAAGGTGCTCAG
GAAGAGGCAATGGAAGAGTTATTAGTGACTTTTCAAAAATTGATTAAAGACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References