Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YafQ-DinJ
Location 2406758..2407314 Replicon chromosome
Accession NZ_CP051634
Organism Treponema denticola strain OMZ 850

Toxin (Protein)


Gene name relE Uniprot ID Q73QZ0
Locus tag E4N83_RS11210 Protein ID WP_002676650.1
Coordinates 2406758..2407039 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q73QZ1
Locus tag E4N83_RS11215 Protein ID WP_002676649.1
Coordinates 2407036..2407314 (-) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E4N83_RS11195 (E4N83_11255) 2401968..2403797 + 1830 WP_253681130.1 signal peptide peptidase SppA -
E4N83_RS11200 (E4N83_11260) 2403836..2404942 + 1107 WP_253681135.1 redox-regulated ATPase YchF -
E4N83_RS11205 (E4N83_11265) 2405125..2406681 - 1557 WP_253681136.1 hypothetical protein -
E4N83_RS11210 (E4N83_11270) 2406758..2407039 - 282 WP_002676650.1 type II toxin-antitoxin system YafQ family toxin Toxin
E4N83_RS11215 (E4N83_11275) 2407036..2407314 - 279 WP_002676649.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
E4N83_RS11220 (E4N83_11280) 2407387..2408190 - 804 WP_253681138.1 class I SAM-dependent methyltransferase -
E4N83_RS11225 (E4N83_11285) 2408264..2409694 - 1431 WP_253681139.1 leucyl aminopeptidase -
E4N83_RS11230 (E4N83_11290) 2410038..2410457 - 420 WP_253681141.1 (deoxy)nucleoside triphosphate pyrophosphohydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(3-92)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(4-70)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10774.68 Da        Isoelectric Point: 10.2467

>T154525 WP_002676650.1 NZ_CP051634:c2407039-2406758 [Treponema denticola]
MIYQLKKTSQFKASVKLAKKRGLNINLLEGIIEKLRTDTPLGVKHKNHQLSGQFKGIWECHIQPDWLLLYLKEENNLVMT
LVDTGTHSDIFKK

Download         Length: 282 bp

>T154525 NZ_CP068143:318250-318357 [Staphylococcus aureus]
ATGTTCAATTTATTAATTGACATCATGACTTCAGCTTTAAGCGGCTGTCTTGTTGCGTTTTTTGCACATTGGTTACGAAC
GCGCAACAATAAAAAAGGTGACAAATAA

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10223.83 Da        Isoelectric Point: 6.2705

>AT154525 WP_002676649.1 NZ_CP051634:c2407314-2407036 [Treponema denticola]
MSTAVLQTRVDSQIKKEADDLFNALGIDTTTAIRLFLKQAINQQKIPFEILPPQKEFSPSVLAAIKEARQISCDASVKQY
KTAKELLADCEV

Download         Length: 279 bp

>AT154525 NZ_CP068143:c318434-318374 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q73QZ0

Antitoxin

Source ID Structure
AlphaFold DB Q73QZ1

References