Detailed information of TA system TA154524

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YafQ-DinJ
• Location: 2203943..2204526
• Replicon: chromosome
• Accession: NZ_CP051634
• Organism: Treponema denticola strain OMZ 850

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: E4N83_RS10335
• Protein ID: WP_253681023.1
• Coordinates: 2204212..2204526 (+)
• Length: 105 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: Q73QD7
• Locus tag: E4N83_RS10330
• Protein ID: WP_002665927.1
• Coordinates: 2203943..2204215 (+)
• Length: 91 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
E4N83_RS10295 (E4N83_10335)	2199898..2200221	+	324	WP_002681645.1	hypothetical protein	-
E4N83_RS10300 (E4N83_10340)	2200328..2201122	+	795	WP_253681020.1	DUF4261 domain-containing protein	-
E4N83_RS10305 (E4N83_10345)	2201199..2201336	+	138	WP_253681021.1	hypothetical protein	-
E4N83_RS10310 (E4N83_10350)	2201560..2202231	+	672	WP_253681022.1	hypothetical protein	-
E4N83_RS10315 (E4N83_10355)	2202287..2202856	+	570	WP_010698587.1	hypothetical protein	-
E4N83_RS10320 (E4N83_10360)	2202901..2203617	+	717	WP_010698586.1	hypothetical protein	-
E4N83_RS10325 (E4N83_10365)	2203668..2203877	+	210	WP_044901886.1	hypothetical protein	-
E4N83_RS10330 (E4N83_10370)	2203943..2204215	+	273	WP_002665927.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
E4N83_RS10335 (E4N83_10375)	2204212..2204526	+	315	WP_253681023.1	type II toxin-antitoxin system YafQ family toxin	Toxin
E4N83_RS10340 (E4N83_10380)	2204569..2205192	+	624	WP_253681024.1	hypothetical protein	-
E4N83_RS10345 (E4N83_10385)	2205230..2206081	+	852	WP_010698582.1	DUF2262 domain-containing protein	-
E4N83_RS10350 (E4N83_10390)	2206118..2206564	+	447	WP_010698581.1	hypothetical protein	-
E4N83_RS10355 (E4N83_10395)	2206615..2206923	+	309	WP_002672586.1	hypothetical protein	-
E4N83_RS10360 (E4N83_10400)	2207007..2208071	+	1065	WP_253681025.1	ankyrin repeat domain-containing protein	-
E4N83_RS10365 (E4N83_10405)	2208253..2209380	+	1128	WP_253681026.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, YafQ-like toxin (3-91)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-89)

Sequences

Toxin

Protein

• Length: 105 a.a.
• Molecular weight: 12503.52 Da
• Isoelectric Point: 9.8020

>T154524 WP_253681023.1 NZ_CP051634:2204212-2204526 [Treponema denticola]
MKYEIKFTNQFKKDIKLAKKQNKNLDKLFKVIDLLSNGEKLEAKYRDHDLSGNYKGTRECHIEPDWLLVYEIRNDVLVLM
LYRLGSHSELFKNIKTENIWRSLQ

Nucleotide

• Length: 315 bp

>T154524 NZ_CP068143:286968-287234 [Staphylococcus aureus]
ATGAGCAATTACACGGTTAAGATTAAAAATTCGGCGAAGTTAGATTTAAAGAAAATAAAACATCCTTATTTAAAGAAGTC
ATTTTTAGAAATTGTTGAGACTTTAAAAAATGATCCGTATAAAATAACACAATCTTTTGAAAAATTAGAGCCTAAATATT
TAGAGCGATATTCAAGAAGAATTAACCATCAGCACAGGGTCGTCTATACCGTAGATGATCGAAATAAAGAAGTATTAATA
CTATCGGCATGGTCACATTATGATTAA

Antitoxin

Protein

• Length: 91 a.a.
• Molecular weight: 10205.78 Da
• Isoelectric Point: 5.1486

>AT154524 WP_002665927.1 NZ_CP051634:2203943-2204215 [Treponema denticola]
MATTNLNIRTDKEMKERAEAIFFELGLNMTTAINIFLRTTIRENGIPFALKLDIPNAITASAIEEGRKIAYDDTVKKYSN
IDDLRKALEI

Nucleotide

• Length: 273 bp

>AT154524 NZ_CP068143:286711-286968 [Staphylococcus aureus]
ATGATTATCACTAGCCCTACAGAAGCGAGAAAAGATTTTTATCAATTACTAAAAAATGTTAATAATAATCACGAACCAAT
TTATATTAGTGGTAATAATGCCGAAAATAATGCTGTGATTATAGGTTTAGAAGATTGGAAAAGTATACAAGAGACAATGT
ATCTTGTATCTACTGGTACAATGGACAAAGTAAGAGAAAGAGAAAAAGATAATAGTGGTACAACAAATATAGATGATATT
GATTGGGATAATCTTTAA

Structures

Antitoxin

• AlphaFold DB: Q73QD7