Detailed information of TA system TA154523

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YoeB-DinJ
• Location: 2077599..2078124
• Replicon: chromosome
• Accession: NZ_CP051634
• Organism: Treponema denticola strain OMZ 850

Toxin (Protein)

• Gene name: relB
• Uniprot ID: M2CK18
• Locus tag: E4N83_RS09615
• Protein ID: WP_002685473.1
• Coordinates: 2077861..2078124 (+)
• Length: 88 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: Q73PY2
• Locus tag: E4N83_RS09610
• Protein ID: WP_002677040.1
• Coordinates: 2077599..2077856 (+)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
E4N83_RS09605 (E4N83_09640)	2075997..2077265	-	1269	WP_010699741.1	OmpA family protein	-
E4N83_RS09610 (E4N83_09645)	2077599..2077856	+	258	WP_002677040.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
E4N83_RS09615 (E4N83_09650)	2077861..2078124	+	264	WP_002685473.1	Txe/YoeB family addiction module toxin	Toxin
E4N83_RS09620 (E4N83_09655)	2078239..2078517	+	279	WP_002669909.1	antitoxin	-
E4N83_RS09625 (E4N83_09660)	2078501..2078908	+	408	WP_147623860.1	type II toxin-antitoxin system VapC family toxin	-
E4N83_RS09630 (E4N83_09670)	2079130..2079369	+	240	WP_002685472.1	hypothetical protein	-
E4N83_RS09635 (E4N83_09675)	2079369..2079773	+	405	WP_010694705.1	type II toxin-antitoxin system VapC family toxin	-
E4N83_RS09640 (E4N83_09680)	2079789..2080694	+	906	WP_253680853.1	YafY family protein	-
E4N83_RS09645 (E4N83_09685)	2080771..2081283	+	513	WP_002681855.1	ClbS/DfsB family four-helix bundle protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (5-84)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-63)

Sequences

Toxin

Protein

• Length: 88 a.a.
• Molecular weight: 10391.93 Da
• Isoelectric Point: 9.7704

>T154523 WP_002685473.1 NZ_CP051634:2077861-2078124 [Treponema denticola]
MIKAWDEDAWIDYVYWQTEDKKTLKRINMLIKDIERNGHNGLGSPEPLKGNLSGFWSRRIDKKNRLVYRIADNVIQIIQC
RTHYGEK

Nucleotide

• Length: 264 bp

>T154523 NZ_CP068140:c29714-29232 [Klebsiella pneumoniae]
GTGGGACGTATAACCACGCCCGAGCCGTTATCCAGCTCTCATCAGCTGGCTGAGTTCGTCAGTGGAGAGACAGTCCTCGA
TGAATGGCTAAAACAGAGAGGTTTAAAAAATCAAGCTCTTGGCGCTGCCCGAACGTTCGTTGTTTGCAAGACGGGTACGA
AGCAAGTAGCTGGTTTTTACTCTTTGGCCACCGGTAGCGTTAACCATACGGAAGCGACAGGTAGTCTTCGGCGTAACATG
CCAGATCCTATACCGGTGATTATACTCGCTCGCCTGGCGGTAGATGTCTCATTGCACGGAAAAGGGGTTGGCGCCGATTT
ACTCCACGATGCAGTTCTACGGTGTTATCGCGTAGCTGAGAACATTGGGGTTCGTGCGATAATGGTTCATGCGCTTACTG
AAGAAGCCAAAGGTTTCTATGCTCACCATGGATTTAAGGCATCACAAACTCATGAGAGGACTCTGTTTCTAAAGCTTCCA
TGA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 9866.39 Da
• Isoelectric Point: 9.5364

>AT154523 WP_002677040.1 NZ_CP051634:2077599-2077856 [Treponema denticola]
MAQINVNIRMDSEVKQEAEQLFDSLGMNMTTAFNIFIRQSLRIGGIPFKIISDERGFYNKYNQKKLHAAAKRMNEGKYIV
HDIVE

Nucleotide

• Length: 258 bp

>AT154523 NZ_CP068140:c29968-29702 [Klebsiella pneumoniae]
ATGAAATCAGATGTTCAACTCAACCTAAGAGCTAAAGAGTCTCAGAGAGCACTCATCGATGCTGCTGCAGAGATCCTTCA
TAAATCGCGAACCGACTTTATCCTGGAGATGGCCTGCAAGGCTGCGGAGAATGTGATCCTTGATCGCCGTGTTTTCAATT
TTAACGACGAACAGTATGCAGAGTTCATCGATATGCTCGATGCACCAGTCGAGGATGAGCCCGCCATTAATAAACTACTG
GCAAGGAAACCTCAGTGGGACGTATAA

Structures

Toxin

• AlphaFold DB: M2CK18

Antitoxin

• AlphaFold DB: Q73PY2