Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 600532..601117 Replicon chromosome
Accession NZ_CP051634
Organism Treponema denticola strain OMZ 850

Toxin (Protein)


Gene name hicA Uniprot ID E9S222
Locus tag E4N83_RS02705 Protein ID WP_002668014.1
Coordinates 600860..601117 (-) Length 86 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID Q73KK4
Locus tag E4N83_RS02700 Protein ID WP_002668012.1
Coordinates 600532..600867 (-) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E4N83_RS02685 (E4N83_02705) 595992..597203 + 1212 WP_002674469.1 substrate-binding domain-containing protein -
E4N83_RS02690 (E4N83_02710) 597314..598807 + 1494 WP_253681659.1 sugar ABC transporter ATP-binding protein -
E4N83_RS02695 (E4N83_02715) 598832..600526 + 1695 WP_253681660.1 galactoside ABC transporter permease -
E4N83_RS02700 (E4N83_02720) 600532..600867 - 336 WP_002668012.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
E4N83_RS02705 (E4N83_02725) 600860..601117 - 258 WP_002668014.1 type II toxin-antitoxin system HicA family toxin Toxin
E4N83_RS02710 (E4N83_02730) 601286..602485 + 1200 WP_253681661.1 galactokinase -
E4N83_RS02715 (E4N83_02735) 602653..603252 + 600 WP_002675657.1 hypothetical protein -
E4N83_RS02720 (E4N83_02740) 603268..604575 + 1308 WP_253681662.1 right-handed parallel beta-helix repeat-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(23-82)

Antitoxin

Uncharacterised protein family HicB

(52-102)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 9589.93 Da        Isoelectric Point: 10.6118

>T154522 WP_002668014.1 NZ_CP051634:c601117-600860 [Treponema denticola]
VNTKNKKTLENIYKRPVPADIFWTDIESLFISLGAEISEGAGSRIRVKLNNTRAVFHRPHPEKITDKGAVNSVRRFLENA
GVKND

Download         Length: 258 bp

>T154522 NZ_CP068139:4607394-4607496 [Klebsiella pneumoniae]
GCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12628.35 Da        Isoelectric Point: 4.9348

>AT154522 WP_002668012.1 NZ_CP051634:c600867-600532 [Treponema denticola]
MIEYKGYIGKIEYDPEAKILHGDVINTRDVITFQGTSVAEIEKAFIDSVDDYINWCREENIEPEKPYSGKFNIRISPELH
KKIAINAKSLNLSLNTFVEKALQHELASTGI

Download         Length: 336 bp

>AT154522 NZ_CP068139:c4607503-4607358 [Klebsiella pneumoniae]
TAAAGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAG
TTGGCATTAATGCAGGCTAAGTCGCCTTGCACTATAAGAATAGTTTAACGCGTCAGCTTTTCCAGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB E9S222

Antitoxin

Source ID Structure
AlphaFold DB Q73KK4

References