Detailed information of TA system TA154521

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YafQ-DinJ
• Location: 2467395..2467951
• Replicon: chromosome
• Accession: NZ_CP051633
• Organism: Treponema denticola strain OMZ 898

Toxin (Protein)

• Gene name: relE
• Uniprot ID: Q73QZ0
• Locus tag: E4N85_RS11485
• Protein ID: WP_002676650.1
• Coordinates: 2467395..2467676 (-)
• Length: 94 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: Q73QZ1
• Locus tag: E4N85_RS11490
• Protein ID: WP_002676649.1
• Coordinates: 2467673..2467951 (-)
• Length: 93 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
E4N85_RS11470 (E4N85_11560)	2462605..2464434	+	1830	WP_253681130.1	signal peptide peptidase SppA	-
E4N85_RS11475 (E4N85_11565)	2464473..2465579	+	1107	WP_253681135.1	redox-regulated ATPase YchF	-
E4N85_RS11480 (E4N85_11570)	2465762..2467318	-	1557	WP_253681136.1	hypothetical protein	-
E4N85_RS11485 (E4N85_11575)	2467395..2467676	-	282	WP_002676650.1	type II toxin-antitoxin system YafQ family toxin	Toxin
E4N85_RS11490 (E4N85_11580)	2467673..2467951	-	279	WP_002676649.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
E4N85_RS11495 (E4N85_11585)	2468024..2468827	-	804	WP_253681138.1	class I SAM-dependent methyltransferase	-
E4N85_RS11500 (E4N85_11590)	2468901..2470331	-	1431	WP_253690256.1	leucyl aminopeptidase	-
E4N85_RS11505 (E4N85_11595)	2470675..2471094	-	420	WP_002681243.1	8-oxo-dGTP diphosphatase MutT	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, YafQ-like toxin (3-92)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (4-70)

Sequences

Toxin

Protein

• Length: 94 a.a.
• Molecular weight: 10774.68 Da
• Isoelectric Point: 10.2467

>T154521 WP_002676650.1 NZ_CP051633:c2467676-2467395 [Treponema denticola]
MIYQLKKTSQFKASVKLAKKRGLNINLLEGIIEKLRTDTPLGVKHKNHQLSGQFKGIWECHIQPDWLLLYLKEENNLVMT
LVDTGTHSDIFKK

Nucleotide

• Length: 282 bp

>T154521 NZ_CP068139:4432301-4432633 [Klebsiella pneumoniae]
ATGGACAGAGGGGAAATCTGGCTTGTTTCACTGGATCCGATTGCTGGCCACGAGCAAAGTGGAAAACGTCCGGTACTCAT
TGTATCGAAGGCATCGTTTAACAAGCTGACCCGACTACCGGTCGTGGTTCCCGTCACCAGCGGCGGAAACTTTGCACGTA
CAGCAGGTTTCACGGTTTCACTGGAAGAGGCGGGGACCAAAACAACAGGCGTTATTCGCTGCGACCAGCCCAGGACTATC
GATATGGCGGCCCGGAAAGGCAAGCGTCTGGAACGCATACCTGACGTCGTTGTCAACGAGGTGCTTGCCAGGCTGGATGC
GATGCTGAGTTAA

Antitoxin

Protein

• Length: 93 a.a.
• Molecular weight: 10223.83 Da
• Isoelectric Point: 6.2705

>AT154521 WP_002676649.1 NZ_CP051633:c2467951-2467673 [Treponema denticola]
MSTAVLQTRVDSQIKKEADDLFNALGIDTTTAIRLFLKQAINQQKIPFEILPPQKEFSPSVLAAIKEARQISCDASVKQY
KTAKELLADCEV

Nucleotide

• Length: 279 bp

>AT154521 NZ_CP068139:4432043-4432300 [Klebsiella pneumoniae]
ATGTATACAACTCGCCTGAAAAAGGTCGGCGGATCCATCATGCTGGCGGTTCCTCCCGCCGTGCTGAAAACGCTGGAGCT
GTCGACGGACAGCGAAGTGGGTATGACCATTGATAATGGCTGCCTGATTATTGAACCCCAGAAACGGCCCCGTTATTCGC
TTGAGGAGCTGCTGGCGCAGTGCGATCCGCACGCCGAAATGAGCGAAGAGGATCGGGAATGGATTGATGCGCCTGCGGTG
GGCAAGGAGATTCTGTAA

Structures

Toxin

• AlphaFold DB: Q73QZ0

Antitoxin

• AlphaFold DB: Q73QZ1