Detailed information of TA system TA154520

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YafQ-DinJ
• Location: 2260315..2260865
• Replicon: chromosome
• Accession: NZ_CP051633
• Organism: Treponema denticola strain OMZ 898

Toxin (Protein)

• Gene name: relE
• Uniprot ID: Q73QD8
• Locus tag: E4N85_RS10545
• Protein ID: WP_002665928.1
• Coordinates: 2260584..2260865 (+)
• Length: 94 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: Q73QD7
• Locus tag: E4N85_RS10540
• Protein ID: WP_002665927.1
• Coordinates: 2260315..2260587 (+)
• Length: 91 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
E4N85_RS10505 (E4N85_10585)	2256238..2256567	+	330	WP_002672558.1	hypothetical protein	-
E4N85_RS10510 (E4N85_10590)	2256674..2257468	+	795	WP_002665906.1	DUF4261 domain-containing protein	-
E4N85_RS10515 (E4N85_10595)	2257545..2257703	+	159	WP_010956759.1	hypothetical protein	-
E4N85_RS10520 (E4N85_10600)	2257905..2258603	+	699	WP_253690159.1	hypothetical protein	-
E4N85_RS10525 (E4N85_10605)	2258659..2259228	+	570	WP_253690160.1	hypothetical protein	-
E4N85_RS10530 (E4N85_10610)	2259273..2259989	+	717	WP_253690161.1	hypothetical protein	-
E4N85_RS10535 (E4N85_10615)	2260040..2260249	+	210	WP_253690162.1	hypothetical protein	-
E4N85_RS10540 (E4N85_10620)	2260315..2260587	+	273	WP_002665927.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
E4N85_RS10545 (E4N85_10625)	2260584..2260865	+	282	WP_002665928.1	type II toxin-antitoxin system YafQ family toxin	Toxin
E4N85_RS10550 (E4N85_10630)	2260940..2261563	+	624	WP_252507515.1	hypothetical protein	-
E4N85_RS10555 (E4N85_10635)	2261601..2262452	+	852	WP_253690163.1	DUF2262 domain-containing protein	-
E4N85_RS10560 (E4N85_10640)	2262474..2263538	+	1065	WP_253690164.1	ankyrin repeat domain-containing protein	-
E4N85_RS10565 (E4N85_10645)	2263715..2264842	+	1128	WP_253690165.1	hypothetical protein	-
E4N85_RS10570 (E4N85_10650)	2264959..2265336	+	378	WP_245522438.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, YafQ-like toxin (3-92)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-89)

Sequences

Toxin

Protein

• Length: 94 a.a.
• Molecular weight: 11113.98 Da
• Isoelectric Point: 9.8023

>T154520 WP_002665928.1 NZ_CP051633:2260584-2260865 [Treponema denticola]
MKYEIKFTNQFKKDIKLAKKQNKNLDKLLKVIDLLSNGEKLEAKYRDHDLSGNYKGTRECHIEPDWLLVYEIRNDVLVLM
LYRLGSHSELFKK

Nucleotide

• Length: 282 bp

>T154520 NZ_CP068139:3470484-3470894 [Klebsiella pneumoniae]
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCGCAGTGGTTTTCCCTGCTGCTTCACGGCGTGGTGGCGGC
CCTGGTGCTGTTGGTTCCCTGGCCGCTGAGCTATACCCCGATCTGGCTGCTGCTGCTGTCGCTGGTGGTCTTCGACTGCG
TGCGCAGCCAGCGGCGGATCCATGCCCGTCGCGGGGAGATAAAACTGCTCACCGATTCCCGTCTTCGCTGGCAAAACGCC
GAATGGGAGATCCTCGGGACGCCGTGGGTTATCAATAGCGGTATGCTGCTGCGTTTGCGCCATGTCGATACCCGGCGCGG
ACAGCATCTTTGGCTGGCGGCGGACAGCATGGACGCCGGAGAGTGGCGCGATCTGCGCCGGCTGGTGCTGCAAAAACCGG
CGCAGGAGTAA

Antitoxin

Protein

• Length: 91 a.a.
• Molecular weight: 10205.78 Da
• Isoelectric Point: 5.1486

>AT154520 WP_002665927.1 NZ_CP051633:2260315-2260587 [Treponema denticola]
MATTNLNIRTDKEMKERAEAIFFELGLNMTTAINIFLRTTIRENGIPFALKLDIPNAITASAIEEGRKIAYDDTVKKYSN
IDDLRKALEI

Nucleotide

• Length: 273 bp

>AT154520 NZ_CP068139:3470237-3470503 [Klebsiella pneumoniae]
ATGGACATTAACAATAAAGCACGTATCCACTGGGCATGCCGCCGCGGGATGCGCGAACTCGACATCTCCATCATGCCGTT
CTTTGAGTATGAGTACGATACCCTCAGCGACGCTGACAAACAGCTGTTCATTCGCCTGCTGGAAAATGACGATCCGGATC
TGTTCAACTGGCTGATGAACCACGGCAAACCGGCCGATGCGGAGCTGCAGCGGATGGTAACCTTAATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Structures

Toxin

• AlphaFold DB: Q73QD8

Antitoxin

• AlphaFold DB: Q73QD7