Detailed information of TA system TA154519

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YoeB-DinJ
• Location: 2093467..2093992
• Replicon: chromosome
• Accession: NZ_CP051633
• Organism: Treponema denticola strain OMZ 898

Toxin (Protein)

• Gene name: relB
• Uniprot ID: M2CK18
• Locus tag: E4N85_RS09605
• Protein ID: WP_002685473.1
• Coordinates: 2093729..2093992 (+)
• Length: 88 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: Q73PY2
• Locus tag: E4N85_RS09600
• Protein ID: WP_002677040.1
• Coordinates: 2093467..2093724 (+)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
E4N85_RS09595 (E4N85_09655)	2091873..2093141	-	1269	WP_253690051.1	OmpA family protein	-
E4N85_RS09600 (E4N85_09660)	2093467..2093724	+	258	WP_002677040.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
E4N85_RS09605 (E4N85_09665)	2093729..2093992	+	264	WP_002685473.1	Txe/YoeB family addiction module toxin	Toxin
E4N85_RS09610 (E4N85_09670)	2094107..2094385	+	279	WP_002669909.1	antitoxin	-
E4N85_RS09615 (E4N85_09675)	2094369..2094776	+	408	WP_147623860.1	type II toxin-antitoxin system VapC family toxin	-
E4N85_RS09620 (E4N85_09685)	2094998..2095237	+	240	WP_002685472.1	hypothetical protein	-
E4N85_RS09625 (E4N85_09690)	2095237..2095641	+	405	WP_010694705.1	type II toxin-antitoxin system VapC family toxin	-
E4N85_RS09630 (E4N85_09695)	2095657..2096562	+	906	WP_253680853.1	YafY family protein	-
E4N85_RS09635 (E4N85_09700)	2096639..2097151	+	513	WP_002681855.1	ClbS/DfsB family four-helix bundle protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (5-84)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-63)

Sequences

Toxin

Protein

• Length: 88 a.a.
• Molecular weight: 10391.93 Da
• Isoelectric Point: 9.7704

>T154519 WP_002685473.1 NZ_CP051633:2093729-2093992 [Treponema denticola]
MIKAWDEDAWIDYVYWQTEDKKTLKRINMLIKDIERNGHNGLGSPEPLKGNLSGFWSRRIDKKNRLVYRIADNVIQIIQC
RTHYGEK

Nucleotide

• Length: 264 bp

>T154519 NZ_CP068139:3002654-3003001 [Klebsiella pneumoniae]
ATGTGGGATGTAGAAACGACGGATACGTTTGATGCCTGGTTCGAATTACAAAGTAGAGCTTTAAAAGAGGATATGTTGGC
CACGATGCTCATCTTGTCTGAGTTTGCTCCGCAGCTTGGGCGCCCGTATGTTGATACGGTGAAAGATTCAACGTTTCAGA
ATATGAAAGAACTCCGGGTTCAGCATCATGGGCTCCCCATCCGCGCCTTTTTTGCTTTTGATCCTCTGCGGAAAGCTATC
GTTTTATGTGCGGGCAATAAGGATGGCATGAATGAGAAACGTTTTTACAAAGAGATGATTACTCTGGCTGACAGAGAATT
CAGCCAACACCTGACTAAGGAGCGATAA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 9866.39 Da
• Isoelectric Point: 9.5364

>AT154519 WP_002677040.1 NZ_CP051633:2093467-2093724 [Treponema denticola]
MAQINVNIRMDSEVKQEAEQLFDSLGMNMTTAFNIFIRQSLRIGGIPFKIISDERGFYNKYNQKKLHAAAKRMNEGKYIV
HDIVE

Nucleotide

• Length: 258 bp

>AT154519 NZ_CP068139:3003001-3003300 [Klebsiella pneumoniae]
ATGGCCACGCTAAAAGAACTCATGGCGAAACAGAGTCCTGAAAGCCAGCAGCGTATTGCAGCGAAAGCGGCAGAGATACG
CCAGTCTGTCGCTTTAAACTTGCTTCGAGAAGAGTTGCAAATGTCGCAAACAGAGATGGCTGCGGCTATGGGGGTAAAGC
AGCCAACGATCGCTAAAATGGAACAGACTGATAACGACCCTCGGCTTTCGACCCTAAAACGCTACATTGCGGCATTGGGG
GGAGAACTCAGTATAAATGTCACATTGCCGACTGGAAAAAAAGTCTCGTTTAATTTGTGA

Structures

Toxin

• AlphaFold DB: M2CK18

Antitoxin

• AlphaFold DB: Q73PY2