Detailed information of TA system TA154517

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/-
• Location: 581281..581866
• Replicon: chromosome
• Accession: NZ_CP051633
• Organism: Treponema denticola strain OMZ 898

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: E9S222
• Locus tag: E4N85_RS02655
• Protein ID: WP_002668014.1
• Coordinates: 581609..581866 (-)
• Length: 86 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: Q73KK4
• Locus tag: E4N85_RS02650
• Protein ID: WP_002668012.1
• Coordinates: 581281..581616 (-)
• Length: 112 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
E4N85_RS02635 (E4N85_02650)	576741..577952	+	1212	WP_002668007.1	substrate-binding domain-containing protein	-
E4N85_RS02640 (E4N85_02655)	578063..579556	+	1494	WP_253690735.1	sugar ABC transporter ATP-binding protein	-
E4N85_RS02645 (E4N85_02660)	579581..581275	+	1695	WP_253690736.1	galactoside ABC transporter permease	-
E4N85_RS02650 (E4N85_02665)	581281..581616	-	336	WP_002668012.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
E4N85_RS02655 (E4N85_02670)	581609..581866	-	258	WP_002668014.1	type II toxin-antitoxin system HicA family toxin	Toxin
E4N85_RS02660 (E4N85_02675)	582035..583234	+	1200	WP_253690737.1	galactokinase	-
E4N85_RS02665 (E4N85_02680)	583402..584001	+	600	WP_253689345.1	hypothetical protein	-
E4N85_RS02670 (E4N85_02685)	584017..585324	+	1308	WP_253689346.1	right-handed parallel beta-helix repeat-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (23-82)

Antitoxin

• Uncharacterised protein family HicB (52-102)

Sequences

Toxin

Protein

• Length: 86 a.a.
• Molecular weight: 9589.93 Da
• Isoelectric Point: 10.6118

>T154517 WP_002668014.1 NZ_CP051633:c581866-581609 [Treponema denticola]
VNTKNKKTLENIYKRPVPADIFWTDIESLFISLGAEISEGAGSRIRVKLNNTRAVFHRPHPEKITDKGAVNSVRRFLENA
GVKND

Nucleotide

• Length: 258 bp

>T154517 NZ_CP068139:c2573763-2573380 [Klebsiella pneumoniae]
ATGACCTCCGGATCTGCGCTTTTTGATACCAATATTCTTATTGATTTATTTAGCGGGCGTCGCGAAGCCAAACAGGCGCT
GGAGGCCTGGCCACCGCAGAATGCGATCAGTCTGATTACCTGGATGGAGGTGATGGTTGGCGCTAAAAAATATCACCAGG
AGCAGCGTACGCGAATGGCGCTGAGCACCTTTAATATCATTAACATCTCACAGGATATTGCAGAGCGAAGCGTTGCGCTG
CGGCAGGAGTATAAGCTTAAGCTGCCGGATGCCATCATTCTGGCGACGGCGCAACTCCATCGTCTGGAACTAATTACGCG
GAATACGAAGGATTTTGCCGGTATTCCTGGCGTAGTCACGCCGTACGAAATCCACCCTGAATAA

Antitoxin

Protein

• Length: 112 a.a.
• Molecular weight: 12628.35 Da
• Isoelectric Point: 4.9348

>AT154517 WP_002668012.1 NZ_CP051633:c581616-581281 [Treponema denticola]
MIEYKGYIGKIEYDPEAKILHGDVINTRDVITFQGTSVAEIEKAFIDSVDDYINWCREENIEPEKPYSGKFNIRISPELH
KKIAINAKSLNLSLNTFVEKALQHELASTGI

Nucleotide

• Length: 336 bp

>AT154517 NZ_CP068139:c2574005-2573763 [Klebsiella pneumoniae]
ATGATGGCTGAAAGGGATATGGGCAGAATTCTTCTCGATTTATCAGACGATGTCATTCAACGTCTCGATGACCTCAAAGT
GCAGCGTAACATTCCGCGAGCGGAACTGTTACGTGAAGCGGTTGAACAATATCTGGAGAAACAAGATCGAGCTAAAGATA
CCATCTCCAGTGCGCTGGGTCTGTGGCAAGACTGCGAAGAAGACGGCATGGAATATCAACGTCAGCTACGCAAGGAGTGG
TAA

Structures

Toxin

• AlphaFold DB: E9S222

Antitoxin

• AlphaFold DB: Q73KK4