Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ataRT/DUF1778(antitoxin)
Location 3215931..3216758 Replicon chromosome
Accession NZ_CP051630
Organism Pyruvatibacter mobilis strain CGMCC 1.15125

Toxin (Protein)


Gene name ataT Uniprot ID -
Locus tag HG718_RS15065 Protein ID WP_160586430.1
Coordinates 3215931..3216446 (-) Length 172 a.a.

Antitoxin (Protein)


Gene name ataR Uniprot ID -
Locus tag HG718_RS15070 Protein ID WP_160586431.1
Coordinates 3216447..3216758 (-) Length 104 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HG718_RS15025 3211035..3212117 - 1083 WP_160586424.1 GTPase ObgE -
HG718_RS15030 3212114..3212707 - 594 WP_160586425.1 GNAT family N-acetyltransferase -
HG718_RS15035 3212903..3213160 - 258 WP_160586426.1 50S ribosomal protein L27 -
HG718_RS15040 3213205..3213516 - 312 WP_027840208.1 50S ribosomal protein L21 -
HG718_RS15045 3213753..3214475 - 723 WP_160586427.1 phosphatidylcholine/phosphatidylserine synthase -
HG718_RS15050 3214590..3215312 + 723 WP_205345611.1 SIMPL domain-containing protein -
HG718_RS15055 3215373..3215564 + 192 WP_160586429.1 hypothetical protein -
HG718_RS15065 3215931..3216446 - 516 WP_160586430.1 GNAT family N-acetyltransferase Toxin
HG718_RS15070 3216447..3216758 - 312 WP_160586431.1 DUF1778 domain-containing protein Antitoxin
HG718_RS15075 3216890..3217480 - 591 WP_160586432.1 hypothetical protein -
HG718_RS15080 3217586..3217939 - 354 WP_160586433.1 aldehyde dehydrogenase -
HG718_RS15085 3218055..3219362 - 1308 WP_160586434.1 sulfite oxidase -
HG718_RS15090 3219588..3220301 + 714 WP_160586435.1 AraC family transcriptional regulator -
HG718_RS15095 3220384..3220815 + 432 WP_160586436.1 nuclear transport factor 2 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(46-144)

Antitoxin

Vibrio phage ICP1, Orf50

(22-97)


Sequences

Toxin        


Download         Length: 172 a.a.        Molecular weight: 18222.87 Da        Isoelectric Point: 7.8771

>T154516 WP_160586430.1 NZ_CP051630:c3216446-3215931 [Pyruvatibacter mobilis]
MASPSVGLPLSAPAPLTTDHVVEGFDCGEPALDHWLAKRALKNESRFSRTYVICQGDRVAAYYSLSAGAVARAAAPGRLR
RNAPDTIPVSIIGRLAVDRAYAGRGLGSDLLADALRRVALAAQTIGISAVLIQAKSDAARSFYLQHAEFLEFPEDSRTLF
LPIDTLMAAIS

Download         Length: 516 bp

>T154516 NZ_CP068139:c2054852-2054568 [Klebsiella pneumoniae]
ATGACCTATGAACTGGAGTTTGATCCACGAGCCTGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCCGCGAATTGAGTCGGCCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA

Antitoxin


Download         Length: 104 a.a.        Molecular weight: 11208.66 Da        Isoelectric Point: 7.0136

>AT154516 WP_160586431.1 NZ_CP051630:c3216758-3216447 [Pyruvatibacter mobilis]
MVQIPTASPSSAAHSADQKRSINLRIEAGTRQLIDQAAAALGKTRTEFMVESARREATDVLLDQRLFALDDTAFNAFVDA
LDNPPSAGPKLRALMSRKPGWQD

Download         Length: 312 bp

>AT154516 NZ_CP068139:c2055084-2054842 [Klebsiella pneumoniae]
ATGGCCACGCTCAATGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACACC
AACGGAGGCGGTACGCCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGGTGAAAAGTATGACCATCAGTGATG
GCGAAGCGGCGTTATTACGCACCGTTCGCGAACGGCTGGAAAACCCACGGCCGGGGGTTAAGGTGAGTCTGGATGACCTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References