Detailed information of TA system TA154513

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/NGN_SP-Phd
• Location: 3746775..3747445
• Replicon: chromosome
• Accession: NZ_CP051627
• Organism: Thermobifida alba strain DSM 43795

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: FOF52_RS16645
• Protein ID: WP_248590857.1
• Coordinates: 3747026..3747445 (+)
• Length: 140 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: FOF52_RS16640
• Protein ID: WP_248590856.1
• Coordinates: 3746775..3747029 (+)
• Length: 85 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FOF52_RS16615 (FOF52_16495)	3741981..3742910	-	930	WP_248590851.1	universal stress protein	-
FOF52_RS16620 (FOF52_16500)	3743177..3743854	+	678	WP_248590852.1	pyridoxamine 5'-phosphate oxidase family protein	-
FOF52_RS16625 (FOF52_16505)	3743920..3744861	+	942	WP_248590853.1	universal stress protein	-
FOF52_RS16630 (FOF52_16510)	3744902..3745579	+	678	WP_248590854.1	response regulator transcription factor	-
FOF52_RS16635 (FOF52_16515)	3745610..3746515	+	906	WP_248590855.1	universal stress protein	-
FOF52_RS16640 (FOF52_16520)	3746775..3747029	+	255	WP_248590856.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
FOF52_RS16645 (FOF52_16525)	3747026..3747445	+	420	WP_248590857.1	type II toxin-antitoxin system VapC family toxin	Toxin
FOF52_RS16650 (FOF52_16530)	3747540..3750221	-	2682	WP_248590858.1	HAD-IC family P-type ATPase	-
FOF52_RS16655 (FOF52_16535)	3750277..3751128	-	852	WP_248590859.1	universal stress protein	-
FOF52_RS16660 (FOF52_16540)	3751445..3752167	+	723	WP_248590860.1	CBS domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	3737269..3750221	12952

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (3-121)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (2-56)

Sequences

Toxin

Protein

• Length: 140 a.a.
• Molecular weight: 15520.87 Da
• Isoelectric Point: 6.9823

>T154513 WP_248590857.1 NZ_CP051627:3747026-3747445 [Thermobifida alba]
VKYLVDTNVISEIRKPNCHPSVRRWQETVSSADLYLSVLVVGEIARGIARLRARDPRQAAVFEDWLERLRIGYADRLLPV
TDAVAVEWGRMSFPDPLPTVDGLLAATAKVYGMTLVTRNTKDFPPGVPVLNPFEEGPSF

Nucleotide

• Length: 420 bp

>T154513 NZ_CP068139:c127400-126078 [Klebsiella pneumoniae]
ATGGCGACGCTTACCACCTGGATGAACAATGTGCGCGTGGGAACCTTAACCCGCCAGGCTAACGGGGCGCACAGTTTTCG
CTATGACGAAGAGTGGCTGCGCAGCCCGCGCGCCAGACCGCTCTCCCTCTCACTGCCGCTGCAGTATGGCAATATCACTG
CCGACGCGGTGTATCACTATTTTGATAACCTGCTGCCCGACAGCCCGCAGGTCCGCGACCGGATCGTCAGGCGCTATCAG
GCGCGCTCGAAGCAGCCGTTCGATCTGCTGGCCGAAGTCGGGCGGGATAGCGTAGGGGCGGTGACCCTCCTGCCGCCGGG
GGAAGAGGCGCACCTGGAAGGATTACGCTGGCAGACGCTGGACGAGGCGCAGCTCACCGCTTTGCTGACCGCTTACCAGT
CGGATATCCCCCTCGGGATGATTACCGGCCAGGACGATTTCCGTATCTCGGTGGCCGGCGCCCAGGAGAAAACGGCGCTG
CTGCGGATGGGCGAGCAGTGGTGTATTCCGCAGGGCGCCACGCCGACCACGCATATCATTAAGCTGCCCATCGGCGAGAT
CAAGCAGCCCAATGCGACGCTGGATCTGCGTGAAAGCGTGGATAATGAGTATTTGTGCCTGGCGCTGGCCAGAGAACTGG
GCCTGGCGGTGCCGGAAGCGGAGATCATCGCCACCCCGCGGATCCGCGCCCTGGCGGTAACCCGCTTCGACCGGCGCTGG
GCGCAGGAGGGACGGGTGCTGCTGCGTCTGCCGCAGGAGGATCTGTGTCAGGCTTTTGGTCTTCCTTCAGCGATGAAATA
TGAGTCTGACGGCGGGCCGGGTATCGCCGCGATCATGACCTTTCTGCTGGGCTCGAGTGAAGCGCTGAAAGATCGCTATG
ACTTTATGAAGTTCATGGTCTTCCAGTGGCTGACGGGGGCGACGGACGGTCACGCAAAAAACTTCTCAATTTACCTGTTG
CCCGGCGGCAGCTACCGCTTAACACCGTTCTACGACATTATTTCGGCGTTTCCGGTGCTGGGCGGCACGGGACTGCATCT
GCGCGATCTGAAGCTGTCGATGGGGCTCAATGCCACAAAAGGGCGTAAAACAGAGATTAACGCCATCTATCCGCGTCATT
TTCTGGCGACGGCCAAAGCGGTGAACTTTCCCCGGGAGCAGATGCTGGCGATCCTCCAGGAGTTTGCCGGGCATGTGCCG
CAGGCAATCGAAAGCGCTCGCCGGACGCTGCCGGCGGACTTTTCCAGCCACGTCTGGCAGGCCATTACAGAGAACATGCT
GAAGCTGCACGCCCGCCTGCAGCAAGGGCTGCAGGCGCTATAG

Antitoxin

Protein

• Length: 85 a.a.
• Molecular weight: 9792.85 Da
• Isoelectric Point: 4.4676

>AT154513 WP_248590856.1 NZ_CP051627:3746775-3747029 [Thermobifida alba]
MHWQIQEAKQRFSELVRSAKTEGPQIVTRHGEEDVVVLDIEEYHRLIGRTQDFKEFLFSGPSMDDLDLSRPTDHPREIDL
GDEA

Nucleotide

• Length: 255 bp

>AT154513 NZ_CP068139:c127666-127400 [Klebsiella pneumoniae]
ATGAATTCCCCGCAGATATACAGTCCCGTGCAGCTGGCCAATTACCTGAAGCTGCTGCGCCAGCAGAACCACTGGACCCA
GGATGCGCTGGCCAGGCGGATCGGCATTAAGCAGGCCACGCTGTCCAATTTTGAAAATCACCCCGACAAAACCACCTTAA
CCACGCTGTTTAAGATCCTCCAGTCGCTGGGGGTGGTGATGATGCTGAACGCCAAAGCTGCTGAGACGGCGCCGGCTCCC
GATAACAACACGGACCTTGACTGGTAA