Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/NGN_SP-Phd
Location 3746775..3747445 Replicon chromosome
Accession NZ_CP051627
Organism Thermobifida alba strain DSM 43795

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag FOF52_RS16645 Protein ID WP_248590857.1
Coordinates 3747026..3747445 (+) Length 140 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag FOF52_RS16640 Protein ID WP_248590856.1
Coordinates 3746775..3747029 (+) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FOF52_RS16615 (FOF52_16495) 3741981..3742910 - 930 WP_248590851.1 universal stress protein -
FOF52_RS16620 (FOF52_16500) 3743177..3743854 + 678 WP_248590852.1 pyridoxamine 5'-phosphate oxidase family protein -
FOF52_RS16625 (FOF52_16505) 3743920..3744861 + 942 WP_248590853.1 universal stress protein -
FOF52_RS16630 (FOF52_16510) 3744902..3745579 + 678 WP_248590854.1 response regulator transcription factor -
FOF52_RS16635 (FOF52_16515) 3745610..3746515 + 906 WP_248590855.1 universal stress protein -
FOF52_RS16640 (FOF52_16520) 3746775..3747029 + 255 WP_248590856.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
FOF52_RS16645 (FOF52_16525) 3747026..3747445 + 420 WP_248590857.1 type II toxin-antitoxin system VapC family toxin Toxin
FOF52_RS16650 (FOF52_16530) 3747540..3750221 - 2682 WP_248590858.1 HAD-IC family P-type ATPase -
FOF52_RS16655 (FOF52_16535) 3750277..3751128 - 852 WP_248590859.1 universal stress protein -
FOF52_RS16660 (FOF52_16540) 3751445..3752167 + 723 WP_248590860.1 CBS domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 3737269..3750221 12952


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-121)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(2-56)


Sequences

Toxin        


Download         Length: 140 a.a.        Molecular weight: 15520.87 Da        Isoelectric Point: 6.9823

>T154513 WP_248590857.1 NZ_CP051627:3747026-3747445 [Thermobifida alba]
VKYLVDTNVISEIRKPNCHPSVRRWQETVSSADLYLSVLVVGEIARGIARLRARDPRQAAVFEDWLERLRIGYADRLLPV
TDAVAVEWGRMSFPDPLPTVDGLLAATAKVYGMTLVTRNTKDFPPGVPVLNPFEEGPSF

Download         Length: 420 bp

>T154513 NZ_CP068139:c127400-126078 [Klebsiella pneumoniae]
ATGGCGACGCTTACCACCTGGATGAACAATGTGCGCGTGGGAACCTTAACCCGCCAGGCTAACGGGGCGCACAGTTTTCG
CTATGACGAAGAGTGGCTGCGCAGCCCGCGCGCCAGACCGCTCTCCCTCTCACTGCCGCTGCAGTATGGCAATATCACTG
CCGACGCGGTGTATCACTATTTTGATAACCTGCTGCCCGACAGCCCGCAGGTCCGCGACCGGATCGTCAGGCGCTATCAG
GCGCGCTCGAAGCAGCCGTTCGATCTGCTGGCCGAAGTCGGGCGGGATAGCGTAGGGGCGGTGACCCTCCTGCCGCCGGG
GGAAGAGGCGCACCTGGAAGGATTACGCTGGCAGACGCTGGACGAGGCGCAGCTCACCGCTTTGCTGACCGCTTACCAGT
CGGATATCCCCCTCGGGATGATTACCGGCCAGGACGATTTCCGTATCTCGGTGGCCGGCGCCCAGGAGAAAACGGCGCTG
CTGCGGATGGGCGAGCAGTGGTGTATTCCGCAGGGCGCCACGCCGACCACGCATATCATTAAGCTGCCCATCGGCGAGAT
CAAGCAGCCCAATGCGACGCTGGATCTGCGTGAAAGCGTGGATAATGAGTATTTGTGCCTGGCGCTGGCCAGAGAACTGG
GCCTGGCGGTGCCGGAAGCGGAGATCATCGCCACCCCGCGGATCCGCGCCCTGGCGGTAACCCGCTTCGACCGGCGCTGG
GCGCAGGAGGGACGGGTGCTGCTGCGTCTGCCGCAGGAGGATCTGTGTCAGGCTTTTGGTCTTCCTTCAGCGATGAAATA
TGAGTCTGACGGCGGGCCGGGTATCGCCGCGATCATGACCTTTCTGCTGGGCTCGAGTGAAGCGCTGAAAGATCGCTATG
ACTTTATGAAGTTCATGGTCTTCCAGTGGCTGACGGGGGCGACGGACGGTCACGCAAAAAACTTCTCAATTTACCTGTTG
CCCGGCGGCAGCTACCGCTTAACACCGTTCTACGACATTATTTCGGCGTTTCCGGTGCTGGGCGGCACGGGACTGCATCT
GCGCGATCTGAAGCTGTCGATGGGGCTCAATGCCACAAAAGGGCGTAAAACAGAGATTAACGCCATCTATCCGCGTCATT
TTCTGGCGACGGCCAAAGCGGTGAACTTTCCCCGGGAGCAGATGCTGGCGATCCTCCAGGAGTTTGCCGGGCATGTGCCG
CAGGCAATCGAAAGCGCTCGCCGGACGCTGCCGGCGGACTTTTCCAGCCACGTCTGGCAGGCCATTACAGAGAACATGCT
GAAGCTGCACGCCCGCCTGCAGCAAGGGCTGCAGGCGCTATAG

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9792.85 Da        Isoelectric Point: 4.4676

>AT154513 WP_248590856.1 NZ_CP051627:3746775-3747029 [Thermobifida alba]
MHWQIQEAKQRFSELVRSAKTEGPQIVTRHGEEDVVVLDIEEYHRLIGRTQDFKEFLFSGPSMDDLDLSRPTDHPREIDL
GDEA

Download         Length: 255 bp

>AT154513 NZ_CP068139:c127666-127400 [Klebsiella pneumoniae]
ATGAATTCCCCGCAGATATACAGTCCCGTGCAGCTGGCCAATTACCTGAAGCTGCTGCGCCAGCAGAACCACTGGACCCA
GGATGCGCTGGCCAGGCGGATCGGCATTAAGCAGGCCACGCTGTCCAATTTTGAAAATCACCCCGACAAAACCACCTTAA
CCACGCTGTTTAAGATCCTCCAGTCGCTGGGGGTGGTGATGATGCTGAACGCCAAAGCTGCTGAGACGGCGCCGGCTCCC
GATAACAACACGGACCTTGACTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References