Detailed information of TA system TA154512

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/Phd(antitoxin)
• Location: 3613783..3614330
• Replicon: chromosome
• Accession: NZ_CP051625
• Organism: Pseudomonas sp. gcc21

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: HG264_RS16785
• Protein ID: WP_169408668.1
• Coordinates: 3614028..3614330 (+)
• Length: 101 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: HG264_RS16780
• Protein ID: WP_169408667.1
• Coordinates: 3613783..3614040 (+)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HG264_RS16755	3609007..3609939	-	933	WP_169408663.1	SDR family oxidoreductase	-
HG264_RS16760	3609932..3610780	-	849	WP_169409186.1	bile acid:sodium symporter family protein	-
HG264_RS16765	3610822..3612150	-	1329	WP_169408664.1	NAD(P)-binding domain-containing protein	-
HG264_RS16770	3612250..3613242	+	993	WP_169408665.1	AraC family transcriptional regulator	-
HG264_RS16775	3613432..3613623	+	192	WP_169408666.1	hypothetical protein	-
HG264_RS16780	3613783..3614040	+	258	WP_169408667.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
HG264_RS16785	3614028..3614330	+	303	WP_169408668.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
HG264_RS16790	3614511..3614738	+	228	WP_169409187.1	hypothetical protein	-
HG264_RS16795	3614824..3615468	-	645	WP_169408669.1	hypothetical protein	-
HG264_RS16800	3615600..3616844	+	1245	WP_169408670.1	FAD-binding oxidoreductase	-
HG264_RS16805	3617265..3617462	+	198	WP_169408671.1	DUF1330 domain-containing protein	-
HG264_RS16810	3617486..3617854	-	369	WP_169408672.1	hypothetical protein	-
HG264_RS16815	3618102..3618617	-	516	WP_169408673.1	hypothetical protein	-
HG264_RS16820	3618620..3619051	-	432	WP_169408674.1	DNA polymerase III subunit chi	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	3605782..3614738	8956

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-90)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-72)

Sequences

Toxin

Protein

• Length: 101 a.a.
• Molecular weight: 11639.39 Da
• Isoelectric Point: 4.6935

>T154512 WP_169408668.1 NZ_CP051625:3614028-3614330 [Pseudomonas sp. gcc21]
MAQIIWTEPALQGLDAIAEYVALDNPSAARNLVEDVFKRTARLEDFPQSGRIPPELPDSVYREVVAPPCRIFYREEGRSV
LILYVMRVEQELRTYMLERR

Nucleotide

• Length: 303 bp

>T154512 NZ_CP068136:1368770-1368949 [Staphylococcus epidermidis]
ATGGCGAACAAAAAAGATTCCAAATTAAATTATCATGAAGAAGAAAATGCTATGGTTACCGACTTAGATGATTTAAAAGA
ATTAGGAAAAGAAATGGAACAGATTTCACAGGAAAATGATGAAGAAAAATTAAATCAATCTCATGATAACGAAGTTCGTT
CAGATTTAAAAAAACAGTAA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 9814.32 Da
• Isoelectric Point: 9.5108

>AT154512 WP_169408667.1 NZ_CP051625:3613783-3614040 [Pseudomonas sp. gcc21]
MKVELVTNLKRQATKILADLHESKEAVLITEHGKPSAYLVDVHDYEFMQRRLALLDGLSRGERAVLEGRTYSQSEAREKM
SKWLK

Nucleotide

• Length: 258 bp

>AT154512 NZ_CP068136:1368147-1368746 [Staphylococcus epidermidis]
ATGGCAATGAATTTTAAAGTATTTGATAATAGTGAAAAAGTAGCAGAATATACTGCAGATATTCTACGTAAGCAGTTTAA
TAATAATCCAACTACTATTGCAGGATTTCATTTGAGCAAAGAACATGCACCAGTGTTTGATGAACTTAAGAAAAATGTAG
AAAATCATACAGTTGATTTCAGTCAAATAAATATTTTAGATTATGATGATAATCATTCTTATTATGAGGCTTTGGGTGTG
CCAACAGGCCAAATTTATTCCATTTCTTACGAAAATGATGCAATTGACTTTATCTCAGATAAGATTAAGACTAAAGAAAA
TAAAGGCAAACTGACAATGCAAGTCCTTACGATTGATGAAAATGGTAAACTTGACATTAGCGTTCGTCAAGGTTTGATGG
AAGCTAGAGAAATTTTCTTAGTTATTACTGGTGCTAATAAACGCGATATGGTAGAAAAACTTTACCGTGAAAATGGTAAG
ACTAGTTTTGAACCATCGGATTTAAAAGCACACCGTATGGTCAATGTTATCTTAGATAAAGAAGCGGCTGCAGGCTTACC
TGAAGACGTAAAAGAGTACTTCACTGCACGTTTTGCATAA