Detailed information of TA system TA154511

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapB(antitoxin)
• Location: 2899469..2900046
• Replicon: chromosome
• Accession: NZ_CP051625
• Organism: Pseudomonas sp. gcc21

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: HG264_RS13355
• Protein ID: WP_169409136.1
• Coordinates: 2899469..2899834 (-)
• Length: 122 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: HG264_RS13360
• Protein ID: WP_169408133.1
• Coordinates: 2899843..2900046 (-)
• Length: 68 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HG264_RS13345	2897398..2897790	+	393	WP_169408131.1	response regulator	-
HG264_RS13350	2897777..2899435	+	1659	WP_169408132.1	diguanylate cyclase	-
HG264_RS13355	2899469..2899834	-	366	WP_169409136.1	type II toxin-antitoxin system VapC family toxin	Toxin
HG264_RS13360	2899843..2900046	-	204	WP_169408133.1	type II toxin-antitoxin system VapB family antitoxin	Antitoxin
HG264_RS13365	2900175..2901833	-	1659	WP_178102817.1	GMC family oxidoreductase	-
HG264_RS13370	2901823..2902464	-	642	WP_169408134.1	gluconate 2-dehydrogenase subunit 3 family protein	-
HG264_RS13375	2902461..2903423	-	963	WP_169408135.1	hypothetical protein	-
HG264_RS13380	2903443..2904552	-	1110	WP_169408136.1	mandelate racemase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Bacterial antitoxin of type II TA system, VapB (1-43)

Sequences

Toxin

Protein

• Length: 122 a.a.
• Molecular weight: 13576.80 Da
• Isoelectric Point: 6.8515

>T154511 WP_169409136.1 NZ_CP051625:c2899834-2899469 [Pseudomonas sp. gcc21]
MVDTSVWVDHFRHGNDALVRLLEFDQVLTHRLIVGEIACGTPPSRNQTLSWLGGLKQAQQASVQETIDFIQRERLYGMGC
GLVDIMLLASTMVTPGAKIWTLDKRLCTMAERLGVMHRPVD

Nucleotide

• Length: 366 bp

>T154511 NZ_CP068136:1175824-1176186 [Staphylococcus epidermidis]
ATGATTAGAAGAGGAGATGTTTATTTAGCGGATTTATCACCAGTTCAAGGGTCTGAACAAGGGGGAGTAAGACCTGTAGT
TATCATTCAAAATGATACTGGTAATAAATATAGTCCAACTGTAATTGTAGCTGCGATTACTGGTAGGATTAATAAAGCGA
AAATACCAACCCACGTAGAAATTGAAAAGAAAAAGTATAAATTAGACAAAGATTCAGTTATTCTTCTTGAACAAATTAGA
ACACTAGATAAAAAGCGTTTAAAAGAAAAATTAACATTTTTATCAGAGAGTAAAATGATAGAGGTTGATAATGCCTTAGA
TATTAGTTTGGGATTAAATAACTTTGATCATCATAAATCTTAA

Antitoxin

Protein

• Length: 68 a.a.
• Molecular weight: 7501.54 Da
• Isoelectric Point: 4.5045

>AT154511 WP_169408133.1 NZ_CP051625:c2900046-2899843 [Pseudomonas sp. gcc21]
MRTTVTIDDALYEEALEVADPSMDKTELFREAVKTFIRVQSAKRLAALGATMPDMQNIPRRSVEASD

Nucleotide

• Length: 204 bp

>AT154511 NZ_CP068136:1175657-1175827 [Staphylococcus epidermidis]
ATGTTATCTTTTAATCAAAATAGAAACCACAGTCTTGAACAATCTTTAAAAGAAGGTTATGCACAAATGGCCGATTTAAA
CCTCTCCCTAGCAACAGAAGCTTTCCCGATAGAGTGTGAAGCTTGTGATTGCAATGAATCACATTTAATATCTAATTCAA
AGAATGAATGA