Detailed information of TA system TA154510

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VagC
• Location: 2579830..2580470
• Replicon: chromosome
• Accession: NZ_CP051625
• Organism: Pseudomonas sp. gcc21

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: HG264_RS11855
• Protein ID: WP_150301754.1
• Coordinates: 2580060..2580470 (+)
• Length: 137 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: HG264_RS11850
• Protein ID: WP_169407875.1
• Coordinates: 2579830..2580060 (+)
• Length: 77 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HG264_RS11830	2575275..2576213	-	939	WP_169407871.1	hydroxymethylbilane synthase	-
HG264_RS11835	2576286..2577035	-	750	WP_169407872.1	LytTR family DNA-binding domain-containing protein	-
HG264_RS11840	2577039..2578118	-	1080	WP_169407873.1	histidine kinase	-
HG264_RS11845	2578229..2579629	+	1401	WP_169407874.1	argininosuccinate lyase	-
HG264_RS11850	2579830..2580060	+	231	WP_169407875.1	antitoxin	Antitoxin
HG264_RS11855	2580060..2580470	+	411	WP_150301754.1	tRNA(fMet)-specific endonuclease VapC	Toxin
HG264_RS11860	2580533..2581630	-	1098	WP_169407876.1	agmatine deiminase	-
HG264_RS11865	2581637..2582515	-	879	WP_169407877.1	N-carbamoylputrescine amidase	-
HG264_RS11870	2582762..2584696	+	1935	WP_169407878.1	PAAR domain-containing protein	-
HG264_RS11875	2584693..2585370	+	678	WP_169407879.1	DUF2931 family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (5-124)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 137 a.a.
• Molecular weight: 15181.46 Da
• Isoelectric Point: 7.3228

>T154510 WP_150301754.1 NZ_CP051625:2580060-2580470 [Pseudomonas sp. gcc21]
MLKFMLDTNICIFTIKNRPQSVREAFTQHHGQMCISTITLMELIYGAEKSSNPERNLAVIEGFATRLEVLSYDQAAAAHT
GQLRAELAKAGTPIGPYDQMIAGHARSQGLIVVTNNRREFERVPGLRIEDWIPPSV

Nucleotide

• Length: 411 bp

>T154510 NZ_CP068136:1164772-1164981 [Staphylococcus epidermidis]
ATGAAATTGAAAAAAGGATTGATAAATGTTTCAGGTATTAAAACAACTGAACAAGCTAAACAGCTCAAAGATCATTTATC
TAAGATGATAGGCATCAATAGTGTGGATATCGATTACCAAATGAATGAGATTCGAGTAGAATTTGACACTCCTGCAAATT
TAAATAACATTGAAAAAGAAATTTACGATTACGGATTTCGTATTTTATAA

Antitoxin

Protein

• Length: 77 a.a.
• Molecular weight: 8554.54 Da
• Isoelectric Point: 4.5680

>AT154510 WP_169407875.1 NZ_CP051625:2579830-2580060 [Pseudomonas sp. gcc21]
MEQGSVFQSNRSQAIRLPKAAALPDDVHRVDIVRLGRARLITPAGESWDSWFEGEGVTADFMIGREQPPEQEREAF

Nucleotide

• Length: 231 bp

>AT154510 NZ_CP068136:1164472-1164765 [Staphylococcus epidermidis]
ATGGCAGACATGGAGAGTGCACATCACTCAGAGCAAATAAAAACAAATTTAAAATCAAGATTAAATAGAATAGAAGGTCA
AGTAAGAGCAATAAATCGTATGATTGATGATGACGTTTACTGTGATGATGTACTAACTCAAATTAGAGCAACACGTTCAG
CATTGAATAGTGTAGCTACTAAATTACTAGACCATCACATGAAAGGTTGTATTATGGAAAAAATAAACGACGGTGCGCAA
GAAGAAGCAATGGATGAATTGCTCGTGACATTCCAAAAATTAATAAAAGATTAA